Immunotherapy with PPD in treatment of warts: An open labelled study from western Uttar Pradesh

Jaiswal, Amit; Gupta, Kamna; Sharma, RP; Bedi, Guneet

doi:10.18231/2581-4729.2019.0010

Cited by 9 publications

(8 citation statements)

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“…In our study, the fifth session of intralesional PPD had the highest cure rates (34.7%), which is in parallel with the results of Gupta et al 21 but Elsayed Ghaly et al 16 reported that the 3rd session had the highest cure rates (40%), and Saoji et al 8 reported clearance of most of the patients (76%) after the 4th session. These variations may be due to inclusion of different age groups, different injection doses, and intervals.…”

Section: Discussionsupporting

confidence: 89%

“…To our knowledge, this is the first study to compare between intralesional PPD and zinc sulfate 2% in the treatment of pediatric warts only without including adults. In this study, there is no significant difference between both groups regarding the overall response, response of the injected and the response of the distant warts with In our study, the fifth session of intralesional PPD had the highest cure rates (34.7%), which is in parallel with the results of Gupta et al 21 but Elsayed Ghaly et al 16 reported that the 3rd session had the highest cure rates (40%), and Saoji et al 8 reported clearance of most of the patients (76%) after the 4th session. These variations may be due to inclusion of different age groups, different injection doses, and intervals.…”

Section: Discussionsupporting

confidence: 87%

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Intralesional purified protein derivative versus zinc sulfate 2% in the treatment of pediatric warts: Clinical and dermoscopic evaluation

Awad

Ismael

Sallam

et al. 2022

J of Cosmetic Dermatology

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Background Warts are common in children and can be difficult to treat. Many treatments for warts are destructive and painful in contrast to intralesional immunotherapy using different types of antigens. Aim To evaluate the efficacy, safety, and tolerability of intralesional purified protein derivative (PPD) versus intralesional zinc sulfate 2% in the treatment of pediatric warts. Methods This randomized clinical trial included 120 children with multiple warts divided into two equal groups. Group Ⅰ received intralesional 10 IU (0.1 ml) of PPD, group Ⅱ received intralesional zinc sulfate 2% in the largest wart every 2 weeks till improvement or for a maximum five treatment sessions. The follow‐up period was 6 months after the last treatment session. Results The overall response was equal in both groups (81.7%), but the response of the injected wart was higher in the zinc sulfate group (93.4%) versus PPD group (83.3%) with no significant difference. The highest cure rates were after the 5th session in the PPD group and the 1st session in the zinc sulfate group with slightly lower numbers of sessions needed for cure in the zinc sulfate group (3 sessions) versus the PPD group (4 sessions). The zinc sulfate group showed statistically significant higher rates of complications (pain, inflammation, necrosis, and scar) than PPD group. The zinc sulfate group showed non‐significant higher rates of recurrence during the follow‐up period. Conclusion Both intralesional PPD and zinc sulfate 2% are effective in pediatric warts with higher safety profile of PPD.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 87%

Intralesional purified protein derivative versus zinc sulfate 2% in the treatment of pediatric warts: Clinical and dermoscopic evaluation

Awad

Ismael

Sallam

et al. 2022

J of Cosmetic Dermatology

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“…9 Genital HPV can be transmitted via sexual and non-sexual route. 4 Transmission rates of HPV between sexual partners are high and can occur without any visible warts. 1 The clinical form of AGW have a highly variable contour appearance as papules or verrucous which may be flat or pedunculated.…”

Section: Discussionmentioning

confidence: 99%

“…This treatment offers long-term immunity with minimal side effects. 4 Purified protein derivative is a sterile protein extract from Mycobacterium tuberculosis. Purified protein derivative antigens are injected into the AGW lesion, which stimulate immune response not only against M. tuberculosis but also against HPV, resulting in warts healing.…”

Section: Introductionmentioning

confidence: 99%

Success of Intralesional Purified Protein Derivative Immunotherapy in the Treatment of Anogenital Warts: A Case Report

Achdiat

Antariksa

Rowawi

et al. 2022

JEP

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Anogenital warts (AGW) are among the most common sexually transmitted infections worldwide. The condition may be persistent, increase in size and number, and have a high recurrence rate. There are many therapeutic options of AGW, but none of them prevented recurrence, only yielded partial responses and have the propensity to cause scars. Immunotherapy by purified protein derivative (PPD) is one of the therapeutic options for AGW, which effectively reduces the number of lesions until complete clearance, with minimal side effects and less recurrence rate. This case report aims to demonstrate the effectiveness, safety, and low recurrence rate of intralesional PPD injection as an alternative therapy for AGW. We reported one case of AGW in an immunocompetent 30-yearold homosexual man who was given 3 doses of 0.2 mL PPD injected intralesionally. As a result, clinical improvement was observed starting from the 18th day, with some of the lesions decreasing in size, and on the 46th day, all of the lesions disappeared. There was no significant side effect. Within two years of follow-up, no recurrence was observed. Intralesional injection of PPD can stimulate the immune response against human papillomavirus (HPV) infection both on the injection site and distant from the injection site. Previous studies have shown promising results of intralesional PPD, with low recurrence in over six-month follow-up and no side effects. Intralesional injection of PPD can be considered as an alternative therapy due to its minimal side effects and its long-term low recurrence rate.

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“…IL mumps, measles, and rubella (MMR) vaccine injection has showed efficacy in treating warts by many studies . 6‐8 Also, tuberculin purified protein derivative (PPD) was injected IL in patients with different types of warts and showed good results 8‐10 . Therefore, PPD seems to be a promising therapy especially in countries where tuberculosis vaccine is routinely given.…”

Section: Introductionmentioning

confidence: 99%

Immunotherapy in cutaneous warts: comparative clinical Study between MMR vaccine, tuberculin, and BCG Vaccine

Shaker

Doghim

Hassan

et al. 2021

J of Cosmetic Dermatology

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Background Warts are common viral infection of the skin. Treating warts are still an ongoing challenge and no general agreement is reached, on the best treatment, despite different therapeutic approaches. Intralesional (IL) immunotherapy has recently been shown to be effective in treating various wart forms. Aims To assess the efficacy and safety of IL tuberculin, IL MMR vaccine, and intradermal (ID) BCG vaccination in treating viral warts. Patients and Methods Sixty patients with single or multiple warts were divided equally into three groups. Group A received IL MMR vaccine, and group B received IL tuberculin every 3 weeks (maximum 3 times). Group C received ID BCG vaccination in the arm with one month interval (maximum 3 times). Recurrence was followed up for 6 months. Results In group A, complete response occurred in 30%, partial response in 5%, and no response in 65%. In group B, complete response occurred in 45%, partial response in 20%, minimal response in 10% and no response in 25%. In group C, complete response occurred in 70%, partial response in 5%, minimal response in 5%, and no response in 20%. No recurrence was observed in group A and B but occurred in one patient in group C with the same lesion. Conclusions Immunotherapy by IL tuberculin and ID BCG vaccination are safe, effective, and inexpensive techniques in treating all types of warts even if recalcitrant or multiple but immunotherapy by IL MMR vaccine has shown less effectiveness and less safety technique.

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Immunotherapy with PPD in treatment of warts: An open labelled study from western Uttar Pradesh

Cited by 9 publications

References 0 publications

Intralesional purified protein derivative versus zinc sulfate 2% in the treatment of pediatric warts: Clinical and dermoscopic evaluation

Intralesional purified protein derivative versus zinc sulfate 2% in the treatment of pediatric warts: Clinical and dermoscopic evaluation

Success of Intralesional Purified Protein Derivative Immunotherapy in the Treatment of Anogenital Warts: A Case Report

Immunotherapy in cutaneous warts: comparative clinical Study between MMR vaccine, tuberculin, and BCG Vaccine

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