Immunotherapy of osteoarthritis against the background of osteoporosis

Objective. To study the relationship between vitamin D level and biochemical blood parameters in patients over 60 years of age with osteoarthritis (OA). Material and methods. In the investigation 200 patients aged 60–80 years (mean age – 69,03±2,34 years; 170 [85%] women and 30 [15%] men) with OA being observed in the out-patient medical institutions of Murmansk including 100 patients after total joint replacement took part. Vitamin D, triglycerides, thyroid stimulating hormone (TSH), total cholesterol, low and high density lipoproteins, blood glucose, uric acid, creatinine, total protein, and blood calcium levels were determined in all patients. Results. Vitamin D deficiency was more frequently observed in the group of patients who did not receive surgical treatment compared to patients who underwent arthroplasty. A statistically significant relationship between vitamin D level and blood glucose was detected in the group of non-prosthetic patients. The relationship between vitamin D level, albumin and TSH was revealed in the group of prosthetic patients.

Relationship of Vitamin D Level With Some Biochemical Indicators of Blood in Patients Over 60 Years of Age With Osteoarthritis Before Surgery and After Prosthetics

Kashpanov,

Popov,

Novikova

et al. 2024

Comparative characteristics of combination treatment with Osteomed and Osteo-Vit D3 for rheumatoid polyarthritis with secondary systemic osteoporosis

Komarov

2023

Vitamin D and Polynucleotides in the Treatment of Osteoarthritis

Kashpanov,

Novikova,

Pronkina

2023

Osteoarthritis occupies a leading position among the causes of disability in patients with rheumatic diseases. The wide prevalence of pathology and the high risk of disability predetermine the need to prevent its development, improve the effectiveness of treatment and conduct rehabilitation measures. The article presents a clinical case on the use of vitamin D and its active metabolites, polynucleotide preparations in the treatment of osteoarthritis. Long-term intake of high doses of vitamin D leads to a decrease in the intensity of pain and functional deficit in patients with osteoarthritis. Vitamin D and its active metabolites compensate for the deficiency of cholecalciferol and thereby reduce the intensity of synovial inflammation in osteoarthritis, at maximum dosages demonstrate a chondroprotective effect by inhibiting apoptosis of chondrocytes, and in the early stages prevent non-adaptive remodeling of the subchondral bone. The results of fundamental and randomized clinical trials allow us to conclude that it is advisable to include vitamin D in the complex therapy of osteoarthritis. It is important to include vitamin D in complex therapy in the early stages of the disease. In addition, there is information in the literature about the use of polynucleotide preparations in the treatment of osteoarthritis. Against the background of treatment with polynucleotide preparations, it is possible to delay the time to arthroplasty, and the need to take non-steroidal anti-inflammatory drugs and opioids decreases.