Immunotherapy of allergic diseases using probiotics or recombinant probiotics

Azevedo, Marcela Santiago Pacheco de; Innocentin, Silvia; Dorella, Fernanda Alves; Rocha, Clarissa Santos; Mariat, Denis; Pontes, Daniela Santos; Miyoshi, Anderson; Azevedo, Vasco; Langella, Philippe; Châtel, Jean-Marc

doi:10.1111/jam.12174

Cited by 33 publications

(19 citation statements)

References 85 publications

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“…Increase in serum concentrations of antigen‐specific IgE and IgG 1 antibodies, which are both anaphylactic antibodies in guinea pigs, were not inhibited by BBG9‐1. This result is not consistent with the general consensus that probiotics have the capacity to create conditions that facilitate re‐direction of allergen‐induced Th2‐skewed responses toward a healthier, regulated Th1/Th2 balance . Previous studies have reported that Lactobacillus strains suppress antigen‐specific IgE production in murine models .…”

Section: Discussioncontrasting

confidence: 83%

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Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9‐1 on Japanese cedar pollen‐induced allergic nasal symptoms in guinea pigs

Tsunemine¹,

Isa²,

Ohno³

et al. 2015

Microbiology and Immunology

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Previous studies using experimental animal models have reported the beneficial effects of probiotics on allergic responses; however, their long-term effects on allergic nasal symptoms in clinical settings have not yet been elucidated in detail. In the present study, a guinea pig allergic rhinitis model involving repeated inhalation challenges with a natural allergen, Japanese cedar pollen, was used to examine the longitudinal effects of Bifidobacterium bifidum G9-1 (BBG9-1) on allergic nasal symptoms. BBG9-1 was administered orally once a day. Amelioration of nasal blockage was consistently observed throughout the experimental period in the BBG9-1-treated group. Although challenge-induced sneezing was not significantly inhibited in the BBG9-1-treated group, prolonged treatment with BBG9-1 slightly reduced the frequency of sneezing. Antigen-specific IgE antibody production was also not inhibited in the BBG9-1-treated group. Increases in the numbers of eosinophils and neutrophils in nasal cavity lavage fluid collected after pollen challenge were almost completely suppressed by BBG9-1 treatment, whereas those in mast cell mediators, histamine and cysteinyl leukotrienes were not. In contrast, increases in the levels of nitric oxide metabolites were potently suppressed. Furthermore, prolonged BBG9-1 treatment markedly suppressed exogenous leukotriene D 4 -induced nasal blockage. Thus, prolonged oral administration of BBG9-1 suppresses Japanese cedar pollen-induced allergic nasal symptoms. The inhibitory mechanisms responsible may involve reductions in the responsiveness of target organs, such as endothelial cells in nasal mucosal blood vessels, to chemical mediators.

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Section: Discussioncontrasting

confidence: 83%

“…Many kinds of organisms have been used as probiotics, the most common being the lactic acid bacteria, lactobacilli and bifidobacteria . The beneficial effects of probiotics against allergic responses have been shown in experimental animal models . Sunada et al .…”

mentioning

confidence: 99%

Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9‐1 on Japanese cedar pollen‐induced allergic nasal symptoms in guinea pigs

Tsunemine¹,

Isa²,

Ohno³

et al. 2015

Microbiology and Immunology

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“…Vaccines using genetically modified LAB as mucosal antigen delivery vehicles have been tested in mouse models of allergies to house dust mites [27–29], eggs [30], birch pollen [31], Japanese cedar pollen [32], and cow's milk [33]. These studies demonstrated suppression of the allergic response by LAB vaccines through induction of immune response by T-helper (Th)1 or regulatory T cells.…”

Section: Resultsmentioning

confidence: 99%

Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides fromβ-Lactoglobulin Secreted byLactococcus lactis

Shigemori

Oshiro

Wang

et al. 2014

BioMed Research International

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Previous studies showed that hydrolysates of β-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus.

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“…Moreover, probiotics use seems to be promising, being these agents are able to modulate the mucosal immune response, and clinical trials demonstrated that specific strains, especially lactic acid bacteria ones, reduce allergic symptoms and may favorite good outcomes of immunotherapy [76].…”

Section: Future Horizonsmentioning

confidence: 99%

Immunotherapy for Food Allergies: A Myth or a Reality?

Praticò

Leonardi

2015

Immunotherapy

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Food allergy is a worldwide issue, with an estimated prevalence of 2-10%. An effective treatment is not available for people affected and the only management is the avoidance of the allergen. Oral immunotherapy and sublingual immunotherapy have been tested by several authors, in particular for milk, egg and peanuts allergy, with significant results in term of desensitization induction. The achievement of tolerance is by the contrary doubtful, with different results obtained. In this review, we reviewed protocols of oral and sublingual immunotherapy for food allergy published in literature, mainly against milk, egg and peanut. At present, immunotherapy does not represent the gold standard in the treatment of food allergy, even if it can desensitize patients.

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Immunotherapy of allergic diseases using probiotics or recombinant probiotics

Cited by 33 publications

References 85 publications

Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9‐1 on Japanese cedar pollen‐induced allergic nasal symptoms in guinea pigs

Longitudinal study of effects of oral dosage of Bifidobacterium bifidum G9‐1 on Japanese cedar pollen‐induced allergic nasal symptoms in guinea pigs

Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides fromβ-Lactoglobulin Secreted byLactococcus lactis

Immunotherapy for Food Allergies: A Myth or a Reality?

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