Immunosuppressive effects of miscellaneous agents

Floersheim, G. L.

doi:10.1007/978-1-349-04636-2_1

Cited by 2 publications

(1 citation statement)

References 167 publications

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“…Our finding of low levels of specific antibody in half of the adult periodontitis and GJP patients may be explained in at least three ways: (i) bacteria serologically distinct from oral B. asaccharolyticus, such as B. melaninogenicus subsp. intermedius or members of the genera Fusobacterium, Capnocytophaga, Selenomonas, Campylobacter, Eubacterium, and Propionibacterium, may predominate in periodontal lesions in these patients, suggesting a periodontopathic potential for organisms other than B. asaccharolyticus (34); (ii) a fluctuation in the subgingival microbial composition may result in periods with low numbers of oral B. asaccharolyticus and a corresponding low level of specific antibody; and (iii) immunosuppression by infecting microorganisms (12,23) may induce immunological unresponsiveness to oral B. asaccharolyticus in patients infected with this organism. Future studies may help answer this question.…”

Section: Discussionmentioning

confidence: 99%

Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): relationship to age and periondontal disease

Mouton¹,

Hammond²,

Slots³

et al. 1981

Infect Immun

284

148

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E(H) 8, p. 79], it was shown that immunoglobulin G (IgG) and IgM antibodies reactive with autoclave extracts of oral strains of B. melaninogenicus subsp. intermedius or B. asaccharolyticus could be detected in the sera of periodontally normal children and adults. The levels of antibody in these normal sera reactive with B. melaninogenicus subsp. intermedius were distinctly higher than those reactive with B. asaccharolyticus. In these pilot studies, it was also shown that patients with adult periodontitis had higher levels of antibodies to B. asaccharolyticus, but not to B. melaninogenicus subsp. inter

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Section: Discussionmentioning

confidence: 99%

Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): relationship to age and periondontal disease

Mouton¹,

Hammond²,

Slots³

et al. 1981

Infect Immun

284

148

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The Immunopharmacology of Immunotoxicology, and Immunorestoration

Caspritz

Hadden

1987

Toxicol Pathol

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The first part of this paper focuses on the secondary immunodeficiencies caused by immunosuppressive drugs and environmental chemicals. The mechanism of action and the therapeutic effects of azathioprine, glucocorticosteroids, cyclophosphamide, cyclosporin A, and anticancer drugs will be discussed. The immunotoxic actions of benzene, polychlorinated and polybrominated biphenyls, tetrachlorodibenzo-paradioxin, polycyclic aromatic hydrocarbons, various insecticides, metals and abused drugs or drugs with side effects are also described. Immunorestorative approaches are discussed in the second part, based on our current knowledge of the immune system and the lymphokines and hormones involved in its function. The usefulness of thymic hormones, interleukin 2, macrophage growth factor/colony stimulating factor, and interferons as immunotherapeutic agents is considered. In addition, we address chemically defined drugs, such as levamisole, diethyldithiocarbamate, isoprinosine, muramyl dipeptides, azimexon, ciamexon, bestatin, tuftsin, and pyrimidinoles, and finally conclude that combined use of different immunostimulants may be the most effective way to treat the above mentioned immunodeficiencies.

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Immunosuppressive effects of miscellaneous agents

Cited by 2 publications

References 167 publications

Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): relationship to age and periondontal disease

Serum antibodies to oral Bacteroides asaccharolyticus (Bacteroides gingivalis): relationship to age and periondontal disease

The Immunopharmacology of Immunotoxicology, and Immunorestoration

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