2014
DOI: 10.1681/asn.2013090945
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Immunosuppressive Effects of Erythropoietin on Human Alloreactive T Cells

Abstract: Correction of anemia with erythropoietin (EPO) is associated with improved kidney transplant outcomes. Emerging evidence, predominantly from animal models, indicates that these observations may be erythropoiesis-independent and that EPO exhibits immunosuppressive properties. We examined the effects of EPO on human T-cell alloimmunity by first documenting that CD4 + and CD8 + T cells express EPO receptor (EPO-R) on their surfaces. In mixed lymphocyte reactions, EPO induced a dose-dependent decrease in allogenei… Show more

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Cited by 52 publications
(61 citation statements)
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References 39 publications
(36 reference statements)
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“…Although the mechanism of action of rhEPO on T lymphocytes is still unclear, it seems that their improved (normalized) phenotype and proliferation capacity in HD patients depends mainly on changes in the concentrations of pro-and antiinflammatory cytokines, which can be regulated by the presence of relevant concentrations of EPO in the serum. Our own studies [18,39] and results of Cravedi et al [44] have shown that the presence of rhEPO may affect the activity of various signaling molecules (e.g., JAK2, AKT or STAT5) in human T lymphocytes stimulated through the CD3/TCR complex in a dose dependent manner and its role in the modulation of T cell activity is probably also related to the number of EPOR molecules on their surface. However, further studies are required in order to explore the mechanisms of the impact of EPO on T lymphocytes.…”
Section: Role Of Erythropoietin and Its Recep-tor In Modulating Immunmentioning
confidence: 60%
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“…Although the mechanism of action of rhEPO on T lymphocytes is still unclear, it seems that their improved (normalized) phenotype and proliferation capacity in HD patients depends mainly on changes in the concentrations of pro-and antiinflammatory cytokines, which can be regulated by the presence of relevant concentrations of EPO in the serum. Our own studies [18,39] and results of Cravedi et al [44] have shown that the presence of rhEPO may affect the activity of various signaling molecules (e.g., JAK2, AKT or STAT5) in human T lymphocytes stimulated through the CD3/TCR complex in a dose dependent manner and its role in the modulation of T cell activity is probably also related to the number of EPOR molecules on their surface. However, further studies are required in order to explore the mechanisms of the impact of EPO on T lymphocytes.…”
Section: Role Of Erythropoietin and Its Recep-tor In Modulating Immunmentioning
confidence: 60%
“…Cravedi et al [44] have published results which confirmed that resting CD4 + and CD8 + cells express low level of EPOR on their surface but its expression is up-regulated after few days of stimulation with anti-CD3 and anti-CD28 antibodies. EPOR up-regulation on T lymphocytes is probably, at least in part, a consequence of an increased EPOR gene expression [44,45] which seems to be dependent on the expression of specific transcription factors [45] .…”
Section: Role Of Erythropoietin and Its Recep-tor In Modulating Immunmentioning
confidence: 93%
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“…In this context, a new study from a team led by Peter Heeger addressed the intriguing question of the immunomodulatory properties of Epo. 18 On the basis of the observations that rhEpo protects against chronic allograft injury in a rat kidney transplant model independently of anemia correction 19 and that rhEpo reduces the clinical expression of murine experimental autoimmune encephalomyelitis, 20 they tested whether rhEpo could shape T-cell functions.…”
mentioning
confidence: 99%