Immunosuppressive effect of infectious bursal agent on vaccination against Newcastle disease

Faragher, J. T.; Allan, W. H.; Wyeth, PJ

doi:10.1136/vr.95.17.385

Cited by 147 publications

(55 citation statements)

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“…Chickens exposed to IBDV are found to develop reduced humoral and cellular immune responses, and to respond poorly to routinely used vaccines (Faragher et al, 1974). IBDV-infected chickens become deficient in the production of optimum levels of antibodies against diverse antigens (Giambrone et al, 1977;Rodenberg et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

T-Cell suppression by cyclosporin-A enhances infectious bursal disease virus infection in experimentally infected chickens

Poonia¹,

Charan²

2001

Avian Pathology

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In this study, the role of T lymphocytes was investigated in chickens experimentally infected with infectious bursal disease virus (IBDV). Chickens were treated with cyclosporin-A (CS-A), a selective T-cell suppressant drug, by the intramuscular route, starting 3 days before virus infection and every third day thereafter, and infectious bursal disease pathogenesis was compared in such T-cell suppressed and intact chickens using a vaccine strain; namely, Georgia and a field isolate of IBDV. Treatment of chickens with CS-A caused a significant suppression of phytohaemagglutinin-A specific proliferative responses of peripheral blood mononuclear cells. The virus neutralizing antibody titres in such CS-A treated chickens were not suppressed. T-Cell suppression resulted in an increase in the severity of gross lesions caused by IBDV and extensive muscular haemorrhages were observed in such chickens between 15 and 21 days post-inoculation. Similarly, there was a marked increase in the severity of infectious bursal disease-specific microscopic lesions in the bursa of T-cell suppressed chickens. Consistently higher titres of virus were observed in bursa of CS-A treated chickens. Virus titres were 1 to 2 log 10 higher in the T-cell suppressed chickens as compared with the intact ones. These studies suggest that T cells play a role in limiting the IBDV infection.

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Section: Introductionmentioning

confidence: 99%

T-Cell suppression by cyclosporin-A enhances infectious bursal disease virus infection in experimentally infected chickens

Poonia¹,

Charan²

2001

Avian Pathology

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“…IBD exists worldwide and its immunosuppressive effect increases the incidence and severity of many other infections [6,17,31]. IBDV shows different degrees of pathogenicity and mortality in chickens.…”

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confidence: 99%

Nucleotide Sequence Analysis of VP2 Hypervariable Domain of Infectious Bursal Disease Virus Detected in Japan from 1993 to 2004

Yamaguchi

Kasanga

Terasaki

et al. 2007

The Journal of Veterinary Medical Science

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ABSTRACT. Bursae of Fabricius were collected from 20 chickens diagnosed with infectious bursal disease virus (IBDV) infection from 15 prefectures in 1993 to 2004. Here we report the nucleotide sequence analysis of VP2 hypervariable domain of IBDV genome detected by reverse transcription-polymerase chain reaction from these samples. Ten sequences derived from 10 prefectures in 1996 to 2003 were of the classical type and other 10 sequences derived from 6 prefectures in 1993 to 2004 were of the highly virulent type. Of the classical type sequences, 9 sequences were closely related to the sequence of classical attenuated vaccines used in Japan. Furthermore, two were identical to the sequence of B-Chi5 which represents Vaccine B passaged 5 times in chickens and was reported to be reverted the virulence during the passages. The 10 highly virulent type sequences were classified into four sequences, none of which had been previously detected in Japan. However, the deduced amino acid sequences were identical to each other and to the sequences of highly virulent IBDVs previously detected in Japan. The most common nucleotide sequences, which accounted for 6 of the sequences, were identical to 34 highly virulent type sequences detected in various countries in BLAST search. This is the first report of detection of the sequence in Japan which is identical to highly virulent strains detected in other countries. These findings show the prevalence of classical IBDVs closely related to the attenuated vaccines and highly virulent IBDVs derived from other countries throughout Japan since 1993.

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“…Results of the serological tests are influenced by a variety of factors including vaccination programmes, possible subclinical infections, circulating infectious bursal disease virus, etc. (Faragher et al, 1974;Pejkovski et al, 1979). Little is known whether serological tests are able to differentiate between flocks with or without clinical IBV infections under field conditions.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the enzyme linked immunosorbent assay, the haemagglutination inhibition test and the agar gel precipitation test for the detection of antibodies against infectious bronchitis and Newcastle disease in commercial broilers

1992

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SUMMARYSerological results as obtained by the agar gel precipitation (AGP) test, haemagglutination inhibition (HI) test (M41, D274, D1466) and an enzyme linked immunosorbent assay (ELISA) from commercial broiler flocks, which had suffered from a clinical infectious bronchitis (IB) infection in the fattening period, were compared with serological findings of control broiler flocks. In addition the Hi-test and ELISA for Newcastle disease (ND) were compared.The AGP results differ significantly between groups. The test had a low sensitivity. The results of the HI-IBV tests were similar for both groups and no difference was seen between flocks with or without clinical IB problems. The IBV ELISA showed a highly significant difference between the two groups.In contrast to the low and not significant correlation coefficients (r) between the IBV HI tests and the ELISA, the value of r between the NDV HI and ELISA was high.The results indicate an ELISA as the preferred test for the diagnosis of IB in broilers.

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Immunosuppressive effect of infectious bursal agent on vaccination against Newcastle disease

Cited by 147 publications

References 0 publications

T-Cell suppression by cyclosporin-A enhances infectious bursal disease virus infection in experimentally infected chickens

T-Cell suppression by cyclosporin-A enhances infectious bursal disease virus infection in experimentally infected chickens

Nucleotide Sequence Analysis of VP2 Hypervariable Domain of Infectious Bursal Disease Virus Detected in Japan from 1993 to 2004

Comparison of the enzyme linked immunosorbent assay, the haemagglutination inhibition test and the agar gel precipitation test for the detection of antibodies against infectious bronchitis and Newcastle disease in commercial broilers

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