Immunosuppression, oxidative stress, and glycometabolism disorder caused by cadmium in common carp (Cyprinus carpio L.): Application of transcriptome analysis in risk assessment of environmental contaminant cadmium

Teng, Xiaohua; Xu, Yong; Han, Qin; Yao, Yuchang; Xing, Houjuan

doi:10.1016/j.jhazmat.2018.12.014

Cited by 140 publications

(22 citation statements)

References 69 publications

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“…The DEGs of P. bursaria were enriched in the KEGG pathway, and many of them were related to oxidative stress, i.e., glutathione metabolism, arachidonic acid metabolism, peroxisome, propanoate metabolism. Antioxidant activity, response to oxidative stress, response to stress, and oxidoreductase activity were also observed in GO terms of the top 20 ( Balboa and Balsinde, 2006 ; Chen et al, 2018 ). Under normal metabolic conditions, the continuous formation of ROS and other free radicals is important for normal physiological functions, such as the production of ATP, the accompanying cellular redox cycles, and various catabolic and anabolic processes ( Rahal et al, 2014 ).…”

Section: Discussionmentioning

confidence: 88%

Toxic Effects of Copper Nanoparticles on Paramecium bursaria–Chlorella Symbiotic System

et al. 2022

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Although many reports have demonstrated that nanoparticles can have a negative effect on aquatic organisms, the toxic effects on symbiotic organisms remain poorly understood. The present study conducts ultrastructure, enzyme activity, and transcriptomics to assess the toxic effects to the Paramecium bursaria–Chlorella symbiotic system from exposure to copper nanoparticles (CuNPs) for 24 h. We found that in both the host and symbiotic algae, CuNP exposure induced high reactive oxygen species level, which leads to oxidative damage and energy metabolism disorder. Moreover, transmission electron micrographs (TEMs) showed that the symbiotic algae in the cytoplasm of P. bursaria were enveloped in the digestive vacuole and digested, and the level of acid phosphatase activity increased significantly within 24 h, which indicated that the stability of the symbiotic system was affected after CuNP exposure. We speculated that the increased energy demand in the host and symbiotic algae resulted from oxidative stress, precipitating the decrease of the photosynthetic products provided to the host, the digestion of the symbiont, and the destruction of the stable symbiotic relationship. The study provides the first insight into the mechanisms of nanoparticles’ toxicity to the symbiotic relationship in the ecosystem, which may help to understand the environmental effects and toxicological mechanisms of nanoparticles.

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Section: Discussionmentioning

confidence: 88%

Toxic Effects of Copper Nanoparticles on Paramecium bursaria–Chlorella Symbiotic System

et al. 2022

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“…In this sense, as a result of growing levels of toxic metals and contaminants in terrestrial and marine environments from natural and anthropogenic sources, the importance of monitoring the impact of toxic elements on living organisms has increased in recent years. Water, soil, environment, plants, livestock, vegetables, meat and seafood are all showed by survey data to be the possible risk of exposure to Cd [ 22 ]. Cd-induced toxicity is mediated by free radical generation and subsequent accumulation of reactive oxygen species (ROS), which plays a crucial role in tissue damage [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Cadmium exposure induces cardiac glucometabolic dysregulation and lipid accumulation independent of pyruvate dehydrogenase activity

et al. 2021

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Context: Suppressed glucose metabolism, elevated fatty acid metabolism and lipid deposition within myocardial cells are the key pathological features of diabetic cardiomyopathy. Studies have associated cadmium exposure with metabolic disturbances. Objective: To examine the effects of cadmium exposure on cardiac glucose homeostasis and lipid accumulation in male Wistar rats. Methods: Male Wistar rats were treated for 21 days as (n ¼ 5): Control, cadmium chloride Cd5 (5 mg/kg, p.o.), cadmium chloride Cd30 (30 mg/kg, p.o). Results:The fasting serum insulin level in this study decreased significantly. Pyruvate and hexokinase activity reduced significantly in the Cd5 group while no significant change in lactate and glycogen levels. The activity of pyruvate dehydrogenase enzyme significantly increased with an increasing dosage of cadmium. The free fatty acid, total cholesterol and triglyceride levels in the heart increased significantly with increasing dosage of cadmium when compared with the control. Lipoprotein lipase activity in the heart showed no difference in the Cd5 group but a reduction in the activity in the Cd30 group was observed. Conclusion:This study indicates that cadmium exposure interferes with cardiac substrate handling resulting in impaired glucometabolic regulation and lipid accumulation which could reduce cardiac efficiency.

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“…Ma et al (2017) study showed that the malondialdehyde (MDA) was increased, while superoxide dismutase (SOD) and catalase (CAT) were decreased in lung tissue of CS-treated mice. In addition, research suggests that harmful gas and heavy metals can cause oxidative stress through increasing MDA, and decrease SOD and CAT to promote the development of disease (Chen et al 2019;Han et al 2020;Shah et al 2020;Guo et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke

Song

Zhou

Cai

et al. 2021

International Journal of Environmental Health Research

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This study was to investigate the effects of oxidative stress in cigarette smoke (CS)-induced cell apoptosis in mice with emphysema. Thirty-two mice were divided into four groups: the control group, the CS group, the CS + Pifithrin-α group, and the CS + NAC group. Pathological changes and apoptosis in lung tissue of mice were detected. The activity of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (T-AOC) were measured using spectrophotometer. The proteins expression of p53, Bcl-2, Bax, and caspase-3 were determined by western blot. The results showed that cell apoptosis, lung structural damage, and the activity of MDA, as well as the expression of apoptosisrelated proteins Bax, total caspase-3, and cleaved caspase-3 were increased in CS-treated mice. The activity of SOD, CAT, and T-AOC, as well as the expression of anti-apoptosis protein Bcl-2 were decreased in CS-treated mice when compared with the control group. However, Pifithrin-α (p53 inhibitor) and N-Acetylcysteine (NAC) could reduce cell apoptosis, lung structural damage and oxidative stress, accelerate the expression of Bcl-2, while suppressing the expression of Bax, total caspase-3 and cleaved caspase-3. More importantly, the treatment with NAC even inhibited the expression of p53. In conclusions, oxidative stress linking the p53 is involved in cell apoptosis in CS-treated emphysema mice.

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Immunosuppression, oxidative stress, and glycometabolism disorder caused by cadmium in common carp (Cyprinus carpio L.): Application of transcriptome analysis in risk assessment of environmental contaminant cadmium

Cited by 140 publications

References 69 publications

Toxic Effects of Copper Nanoparticles on Paramecium bursaria–Chlorella Symbiotic System

Toxic Effects of Copper Nanoparticles on Paramecium bursaria–Chlorella Symbiotic System

Cadmium exposure induces cardiac glucometabolic dysregulation and lipid accumulation independent of pyruvate dehydrogenase activity

Oxidative stress links the tumour suppressor p53 with cell apoptosis induced by cigarette smoke

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