Immunosuppression by human seminal plasma

Saxena, Sunil; Jha, P.; Farooq, A.

doi:10.3109/08820138509076149

Cited by 18 publications

(6 citation statements)

References 17 publications

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“…It has been known for several decades that seminal plasma from various species can directly affect the immunological functions of T cells, B cells, NK cells and macrophages in vitro [65][66][67]. While it does not directly influence the generation of tolerogenic lymphocytes, seminal fluid has been shown to impair complement dependent antibody cell lysis and cell mediated killing of pathogenic bacteria [68].…”

Section: Immunological Actions Of Seminal Plasmamentioning

confidence: 99%

Seminal fluid and reproduction: much more than previously thought

Bromfield

2014

J Assist Reprod Genet

125

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The influence of seminal plasma on the cytokine and immune uterine environment is well characterised in mice and humans, while the effects of disruption to uterine seminal plasma exposure on pregnancy and offspring health is becoming more clearly understood. The cellular and molecular environment of the uterus during the pre-and peri-implantation period of early pregnancy is critical for implantation success and optimal foetal and placental development. Perturbations to this environment not only have consequences for the success of pregnancy and neonatal health and viability, but can also drive adverse health outcomes in the offspring after birth, particularly the development of metabolic disorders such as obesity, hypertension and insulin resistance. It is now reported that an absence of seminal plasma at conception in mice promotes increased fat accumulation, altered metabolism and hypertension in offspring. The evidence reviewed here demonstrates that seminal plasma is not simply a transport medium for sperm, but acts also as a key regulator of the female tract environment providing optimal support for the developing embryo and benefiting future health of offspring.

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Section: Immunological Actions Of Seminal Plasmamentioning

confidence: 99%

Seminal fluid and reproduction: much more than previously thought

Bromfield

2014

J Assist Reprod Genet

125

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“…Medwar proposed the immunological paradigm of viviparity in the 1950s and postulated that specific mechanisms must exist to allow the semi-allogenic conceptus to reside within the maternal tissues throughout gestation without the threat of immunological clearance (Medwar 1953). SP itself has the capacity to modulate the function of immune cells in vitro (Anderson & Tarter 1982, Saxena et al 1985. However, it has become evident that SP has the capacity to also alter systemic immune function when delivered at coitus.…”

Section: Sp-induced Inflammation and Immune Modulation In Maternal Timentioning

confidence: 99%

A role for seminal plasma in modulating pregnancy outcomes in domestic species

Bromfield¹

2016

Reproduction

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Seminal plasma is a complex fluid produced by the accessory glands of the male reproductive tract. Seminal plasma acts primarily as a transport medium for sperm on its arduous journey through the male and then female reproductive tract following ejaculation. This spermatozoan expedition will hopefully result in the meeting of and resultant fertilization of an oocyte, perpetuating the genetic lineage of both sexes. Whereas seminal plasma has historically been perceived as only a transport medium providing a nutrient-rich fluid environment for sperm during this exchange of genetic material, new insights into a complex communication pathway between males and females has been unraveled in the past 30 years. This new research suggests seminal plasma as a method to promote early pregnancy success by modulating cellular and molecular adaptions of the maternal environment required to facilitate healthy, successful pregnancy outcomes. Whereas much work on this exciting new communication process has focused on mice and translation to human reproduction, here we review the current evidence in domestic species where artificial insemination in the absence of seminal plasma is routine. Improving artificial insemination in domestic species to optimize offspring health and productivity could have far-reaching impacts on agriculturally relevant species such as cattle, sheep, pigs and horses.Reproduction (2016) 152 R223-R232

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“…There have been many reports that seminal plasma has various immunosuppressive activities (Pitout & Jordaan, 1976;Prakash et al, 1976;Marcus et al, 1978;Petersen et al, 1980;Anderson & Tarter, 1982;Thomas & Erickson, 1984;Saxena et al, 1985;Tarter et a[., 1986;Bouvet el al., 1987). Secretions from the testis make up < 2% of the volume of the ejaculate.…”

Section: Discussionmentioning

confidence: 99%

Suppressive effect of a mouse testicular extract on lymphocyte activation

et al. 1991

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The effect of mouse testicular extract (TE) on lymphocyte activation was investigated. TE, in the dose range 75-600 micrograms ml-1, suppressed significantly the blastogenic response of splenocytes to concanavalin A (Con-A), pokeweed mitogen (PWM), phytohaemagglutinin (PHA) and lipopolysaccharide (LPS). TE also suppressed the blastogenic response of B-cells to LPS and of T-cells to PHA in a dose-dependent manner as well as suppressing the mixed lymphocyte reaction (MLR). Pretreatment of splenocytes with TE did not however, completely suppress their blastogenic response to Con-A, when the treated cells were washed prior to culturing. Furthermore, TE did not inhibit the on-going blastogenesis of splenocytes that had been activated already with Con-A for 48 h. Splenocytes obtained from TE-treated mice remained capable of responding to Con-A stimulation, whereas they did not respond to listerial antigens when mice were immunized with Listeria monocytogenes together with TE. The effects of TE were enhanced significantly by heating to 100 degrees C, but were resistant to pronase, RNase and DNase. These results suggest that TE affects non-specifically the stage of lymphocyte sensitization to antigens or mitogens.

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Immunosuppression by human seminal plasma

Cited by 18 publications

References 17 publications

Seminal fluid and reproduction: much more than previously thought

Seminal fluid and reproduction: much more than previously thought

A role for seminal plasma in modulating pregnancy outcomes in domestic species

Suppressive effect of a mouse testicular extract on lymphocyte activation

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