Immunostimulation with Bacterial Phospholipid Extracts

Fauve, Robert M.; Hévin, Brigitte

doi:10.1073/pnas.71.2.573

Cited by 41 publications

(14 citation statements)

References 11 publications

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“…It has been reported that a host's resistance to bacterial infection can be increased by pretreatment with bacterial whole cells, with cell wall skeletons, and with bacterial extract(s), e.g., cord factor (43) and phospholipid (20) derived from various species of microorganisms, such as Mycobacterium (7,9,17,18,45), Listeria (10), and Corynebacterium (3,24).…”

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confidence: 99%

Stimulation of Nonspecific Host Resistance to Infection Induced by Muramyldipeptides

Matsumoto

Ogawa

Nagase

et al. 1981

Microbiology and Immunology

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The effect of muramyldipeptide (MDP), N-acetylmuramyl-L-alanyl-Disoglutamine [MDP(Ala)], and its analogs on bacterial infection was studied using the experimental model of sepsis infection in mice. Injection of MDP(Ala) gave mice definitive protection against E. coli infection, but only partial protection against P. aeruginosa or K. pneumoniae infection. Several factors influencing the protective activity of MDP(Ala) on E. coli infection were studied, and it was demonstrated that the activity was induced by various routes of administration of MDP(Ala), including the oral route, and was markedly influenced by the bacterial inoculum size. It was also shown that the effective dose of MDP(Ala) was 100 flg per mouse for intraperitoneal, intravenous or subcutaneous injections and 1,000 flg per mouse when administered orally. Furthermore, the optimal interval between MDP-treatment and infection was 24 hr when the treatment was carried out before infection. Clearance of bacterial cells in blood was observed after E. coli infection in mice treated with MDP(Ala).The efficacy of MDP(Ala) and two analogs, N-acetylmuramyl-L-valyl-Disoglutamine [MDP(Val)] and N-acetylmuramyl-L-seryl-D-isoglutamine [MDP (Ser)], was evaluated for the E. coli infection; MDP(Val) was proven to be slightly less active than MDP(Ala), and MDP(Ser) to be the least effective, although MDP(Val) or MDP(Ser) was reported to have higher adjuvanticity than MDP (Ala) for the development of delayed-type hypersensitivity.

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confidence: 99%

Stimulation of Nonspecific Host Resistance to Infection Induced by Muramyldipeptides

Matsumoto

Ogawa

Nagase

et al. 1981

Microbiology and Immunology

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“…Nonspecific immunity can be enhanced by corynebacteria (9,10) and other bacterial preparations, such as cord factor (11)(12)(13) or a bacterial phospholipid extract (14). Administered under adequate conditions, such bacterial agents very markedly increase nonspecific immunity, even against strains made resistant to antibiotics by mutation or plasmid transfer (10).…”

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confidence: 99%

Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.

Chedid¹,

Parant²,

Parant³

et al. 1977

Proc. Natl. Acad. Sci. U.S.A.

204

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N-Acetylmuramyl-L-alanyl-D-isoglutamine and four other synthetic adjuvants that are structural analogs of part of the mycobacterial peptidoglycan monomer are shown to enhance the nonspecific immunity of mice infected by Kiebsiella pneumoniae. These compounds are active by various routes, including oral administration; they are also effective when administered after challenge. Of the seventeen other analogs tested, none is able to increase significantly resistance to infection, although seven of these molecules are adjuvant-active in saline. Previous results have shown that in contrast to lipopolysaccharides, these synthetic adjuvants are devoid of immunogenicity, mitogenicity, and toxicity in normal or adrenalectomized mice.

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“…This LAB contains endotoxins (LPS) (Howard et al 1957 ;Fauve and Hevin 1974;Awaguchi 1980) which are, according to dosage, immunostimulants or immunosuppressors. …”

Section: Resultsmentioning

confidence: 99%

Immunomodulation in offspring mice after neonatal immunostimulation of mothers or newborn mice.

Binder

Huart

et al. 1985

Tohoku J. Exp. Med.

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383 --Mothers of offspring Balb/c mice were stimulated after birth by two substances, a bacterial lysate (LAB) and a chemical, diethyldithiocarbamate (DETC). Anti-sheep red blood cell (SRBC) antibodies were studied after immunization of stimulated mothers or offspring. An increase of anti-SRBC was observed in LAB-stimulated mothers, but these antibodies were decreased in their offspring before weaning. Sometimes, these antibodies were increased in LABstimulated newborn mice. DETC stimulation of mothers induced an elevation of antibody response in mothers and newborns. The same results were obtained in previous investigations where the pregnant mother was stimulated with the same agents.immunomodulation ; pregnant mice ; offspring miceIn a recent study we demonstrated that the antibody response of newborn mice could be modulated by non-specific immunomodulation of the mother during gestation ; we observed an inhibition of the anti-sheep red blood cells by a bacterial lysate (LAB) and potentiation of this response if diethyldithiocarbamate sodium (DETC) was used. Recent investigations have demonstrated the immunomodulatory properties of hormones (Deschaux et al. 1980), or of other factors which appear during gestation (Koutab et al. 1976;Noonan et al. 1979). In the same way, a significant immunosuppressor activity in the splenic cells of newborn mice was observed. (Argyris 1978(Argyris , 1979(Argyris , 1982.In this investigation we intended to examine whether the mother's immunomodulatory factors, responsible for variations in the antibody response observed in our own prior investigation, could be transferred to the offspring

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Immunostimulation with Bacterial Phospholipid Extracts

Cited by 41 publications

References 11 publications

Stimulation of Nonspecific Host Resistance to Infection Induced by Muramyldipeptides

Stimulation of Nonspecific Host Resistance to Infection Induced by Muramyldipeptides

Enhancement of nonspecific immunity to Klebsiella pneumoniae infection by a synthetic immunoadjuvant (N-acetylmuramyl-L-alanyl-D-isoglutamine) and several analogs.

Immunomodulation in offspring mice after neonatal immunostimulation of mothers or newborn mice.

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