Immunomodulation in offspring mice after neonatal immunostimulation of mothers or newborn mice.

Abstract

383 --Mothers of offspring Balb/c mice were stimulated after birth by two substances, a bacterial lysate (LAB) and a chemical, diethyldithiocarbamate (DETC). Anti-sheep red blood cell (SRBC) antibodies were studied after immunization of stimulated mothers or offspring. An increase of anti-SRBC was observed in LAB-stimulated mothers, but these antibodies were decreased in their offspring before weaning. Sometimes, these antibodies were increased in LABstimulated newborn mice. DETC stimulation of mothers induced an elevation of antibody response in mothers and newborns. The same results were obtained in previous investigations where the pregnant mother was stimulated with the same agents.immunomodulation ; pregnant mice ; offspring miceIn a recent study we demonstrated that the antibody response of newborn mice could be modulated by non-specific immunomodulation of the mother during gestation ; we observed an inhibition of the anti-sheep red blood cells by a bacterial lysate (LAB) and potentiation of this response if diethyldithiocarbamate sodium (DETC) was used. Recent investigations have demonstrated the immunomodulatory properties of hormones (Deschaux et al. 1980), or of other factors which appear during gestation (Koutab et al. 1976;Noonan et al. 1979). In the same way, a significant immunosuppressor activity in the splenic cells of newborn mice was observed. (Argyris 1978(Argyris , 1979(Argyris , 1982.In this investigation we intended to examine whether the mother's immunomodulatory factors, responsible for variations in the antibody response observed in our own prior investigation, could be transferred to the offspring

Therapy of Acute Respiratory Infections in Children: Novelties

“…4). In 1985 P. Binder et al [15] proved immunostimulating effect of Broncho-Vaxom in young mice by means of an experiment with reference to the data obtained by J. Clot and M. Amdary published in journal "Medicine and Hygiene" (Geneva) in 1980.…”