Immunostimulation as a Therapeutic Principle in Bacterial Infections: The Effect of the Immunomodulator Bestatin on the Experimental Chronic E. coli Urinary Tract Infection

Dickneite, Gerhard; Schorlemmer, H. U.; Hofstaetter, T.; Sedlacek, H.H.

doi:10.1007/978-3-642-70524-3_32

Cited by 3 publications

(1 citation statement)

References 8 publications

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“…However, these techniques involve an increase in the processing time of semen. Others approaches for overcoming bacterial growth include the use of active molecules such as EDTA, [ 26 ], chitosan [ 27 , 28 ], nanoparticles [ 29 ], peptides [ 30 , 31 ] and aminopeptidase inhibitors [ 18 , 32 ], etc., with recognised antibacterial activity. EDTA is known to increase the outer cell wall permeability of Gram-negative bacteria, allowing other molecules easier access into the cell, facilitating an alteration or inhibition of its metabolism [ 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Some Molecules Added to Rabbit Semen Extender as Alternative to Antibiotics

Viudes-de-Castro

Marco‐Jiménez

Vicente

et al. 2021

Animals

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Although great attention is paid to hygiene during semen collection and processing, bacteria are commonly found in the semen of healthy fertile males of different species. As the storage of extended semen might facilitate bacterial growth, extenders are commonly supplemented with antibiotics. This study aimed to evaluate the antibacterial activity of ethylenediaminetetraacetic acid (EDTA), bestatin and chitosan-based nanoparticles added to rabbit semen extender and their effect on reproductive performance under field conditions. Four different extenders were tested, supplemented with antibiotics (TCG+AB), with EDTA and bestatin (EB), with EDTA, bestatin and chitosan-based nanoparticles (QEB) or without antibiotics (TCG-AB). Extended semen was cooled at 15 °C for three days. Cooled samples were examined for bacterial growth and semen quality every 24 h for 3 days. The enterobacteria count increased considerably during storage at 72 h in semen extended with TCG+AB and TCG-AB, while extenders EB and QEB showed a bacteriostatic effect over time. After 24, 48 and 72 h, quality characteristics were retained in all groups, with no significant motility differences, either in acrosome integrity, membrane functionality or the viability of spermatozoa. Additionally, bacterial concentration present in fresh semen did not affect reproductive performance. In conclusion, EDTA and bestatin exerted a potent bacteriostatic effect over time and could be used as an alternative to conventional antibiotics in rabbit semen extenders.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Some Molecules Added to Rabbit Semen Extender as Alternative to Antibiotics

Viudes-de-Castro

Marco‐Jiménez

Vicente

et al. 2021

Animals

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Influence of the immunostimulating substance tiprotimod on Candida Albicans infection in relation to activation of macrophages

Dickneite

Schorlemmer

Sedlacek

1989

International Journal of Immunopharmacology

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Trends in rabbit insemination extenders for fresh and frozen semen. A review

Viudes-de-Castro

Vicente

2023

World Rabbit Sci.

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Artificial insemination (AI) has become a popular technique in rabbit farms worldwide. This report discusses the progress made on semen extenders used in rabbit AI, setting out the latest innovations. Fresh and frozen semen have different requirements, so the extender composition will vary depending on the type of semen used. We discuss the endocrine supplementation of extenders for ovulation induction, the use of active molecules as an alternative to conventional antibiotics and the extenders developed for rabbit sperm cryopreservation.

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Immunostimulation as a Therapeutic Principle in Bacterial Infections: The Effect of the Immunomodulator Bestatin on the Experimental Chronic E. coli Urinary Tract Infection

Cited by 3 publications

References 8 publications

Antibacterial Activity of Some Molecules Added to Rabbit Semen Extender as Alternative to Antibiotics

Antibacterial Activity of Some Molecules Added to Rabbit Semen Extender as Alternative to Antibiotics

Influence of the immunostimulating substance tiprotimod on Candida Albicans infection in relation to activation of macrophages

Trends in rabbit insemination extenders for fresh and frozen semen. A review

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