Immunostimulant activity of noni (<i>Morinda citrifolia</i>) on T and B lymphocytes

Nayak, Smita; Mengi, S.A.

doi:10.3109/13880200903264434

Cited by 43 publications

(33 citation statements)

References 37 publications

(36 reference statements)

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“…The fNE injection induced complete tumor rejection in normal C57BL/6J mice in both (15). This conclusion has been supported in a recent study by Nayak and Mengi (16).…”

Section: Introductionsupporting

confidence: 72%

Antitumor activity of fermented noni exudates and its fractions

Chang

Wall

et al. 2012

Molecular and Clinical Oncology

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Abstract. Noni has been extensively used in folk medicine by Polynesians for over 2000 year. Recent studies have shown that noni has a wide spectrum of therapeutic activities including inhibition of angiogenesis, anti-inflammatory effects and anticancer activities. Intraperitoneal (i.p.) injection of fermented noni exudates (fNE) were previously found to induce significant tumor rejection in a S180 mouse sarcoma tumor model, while natural killer (NK) cells were demonstrated to be markedly involved in fNE-induced antitumor activity. In this study, fNE was partitioned into three fractions and their antitumor effects were examined using i.p. injection or as water supplement. The in vivo animal study results showed that when delivered by i.p. injection, n-butanol fraction of fNE (BuOH) effectively rejected (100%) tumor challenge and eradicated existing tumors (75%). When delivered as a water supplement, 62.5% of the mice receiving the n-butanol or ethyl acetate fractions resisted tumor cells. The tumor-resistant mice effectively rejected more and higher doses of tumor challenge, indicating that the immune system was activated. The findings confirm those of an earlier study showing fNE to have antitumor activity and demonstrating that the n-butanol fraction of fNE contains active antitumor components, to be further identified. More importantly, the antitumor effect of fNE and its fractions as water supplements renders a significant potential for identifying novel and powerful new dietary products for cancer prevention.

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“…The fNE injection induced complete tumor rejection in normal C57BL/6J mice in both (15). This conclusion has been supported in a recent study by Nayak and Mengi (16).…”

Section: Introductionsupporting

confidence: 72%

Antitumor activity of fermented noni exudates and its fractions

Chang

Wall

et al. 2012

Molecular and Clinical Oncology

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“…carbohydrates, gums and mucilages, proteins, amino acids, fats and oils, anthraquinone glycosides, coumarin glycosides, flavonoids, alkaloids, tannins, phenolic compounds and citric acid which are responsible for several activities including the immunostimulation (Nayak et al, 2012). Studies showed that M. citrifolia stimulated the immune system for anti tumor, anticancer, antioxidant activities both in-vivo and in-vitro (Hirazumi & Furusawa, 1999;Furusawa & Hirazumi, 2003;Palu et al, 2006;Nayak & Mengi, 2010;Mufidah et al, 2013;Assi et al, 2015;Krishnaiah et al, 2015). However, very few reports are available on the use of M. citrifolia as imnomostimulant in livestock and poultry (Sunder et al, 2007;Lohani, 2010;Sunder et al, 2011a;Benjamin et al, 2014).…”

Section: Citrifolia As Immunomodulatormentioning

confidence: 99%

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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KEYWORDS Morinda citrifolia Livestock Poultry Growth Production Immunomodulatory Properties ABSTRACTMorinda citrifolia L. is commonly known as Noni and has been found to have wide range of medicinal properties. It is usually found in the coastal region in many countries including Andaman and Nicobar Islands and belongs to the family Rubiaceae. This small evergreen tree is widely grown and well adapted to the tropics and can grow in fertile, acidic, alkaline and saline affected soils. It tolerates high soil salinity and brackish water stagnation. All the components of this plant have high demand in case of alternative medicines and herbal medicines. Due to its high demand and as a source of revenue generation the detail study on its nutritional benefits and therapeutic values are essential for its commercial exploitation. More than 200 nutraceutical compounds have been identified from the plant. Morinda citrifolia is reported to have broad spectrum biological activities such as antimicrobial, immunomodualtory, antioxidant wound healing etc. Apart from the in-vitro scientific validation of the activities and in-vivo trial in some lab animal model, the plant has been used for livestock and poultry health and production. A lot of reviews have been written on the different uses of Noni, however, scientific review on the use of this plant on the growth, production, immunomodulator and other pharmacological activities of M. citrifolia in livestock and poultry has not been compiled. Therefore this review discusses the compilation of the work done on the use of M. citrifolia in livestock and poultry.

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“…61 Hepatoprotective activity Acute liver injury induced by carbon tetrachloride (CCl 4 ) in female Sprague-Dawley (SD) rats was found reversed by Noni juice. In the placebo group, administered CCl 4 with drinking water which was induced liver damage in rats.…”

Section: Immunostimulant Activitymentioning

confidence: 99%

Health Benefits of Morinda citrifolia (Noni): A Review

Ali¹,

Kenganora²,

Manjula³

2016

Phcogj

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Background: Morinda citrifolia (Noni) has been used widely as a comple mentary and alternative therapy in many countries owing to its potent anti oxidant activity and proven health benefits. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, anti inflammatory, immunostimulant. Also it has proved beneficial in conditions like gastritis, skin diseases, respiratory infections, menstrual and urinary tract disorders, fever, diabetes and venereal diseases. Objective: This review emphasizes on the phytochemical and mineral profile of the different parts of Noni plant. In addition, this review corroborates the pharmacological basis for the various health benefits, traditional and medicinal applications of Noni. Materials and Methods: All the available information of Noni were collected from electronic databases such as Academic Journals, Ethnobotany, Ethnopharmacology, Springer, PubMed, Google Scholar, Science Direct and other primary and secondary sources. Results: According to our search results pertaining to scientific literature, Morinda citrifolia is used for more than 40 types of ailments worldwide. Crude extract of various parts of plant and fruit juice are reported

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Immunostimulant activity of noni (Morinda citrifolia) on T and B lymphocytes

Cited by 43 publications

References 37 publications

Antitumor activity of fermented noni exudates and its fractions

Antitumor activity of fermented noni exudates and its fractions

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Health Benefits of Morinda citrifolia (Noni): A Review

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