2002
DOI: 10.1007/s00436-001-0559-2
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Immunosensors for diagnostic applications

Abstract: Immunosensors can play an important role in the improvement of veterinary diagnostics in areas such as the diagnosis of diseases, drug detection and food quality control, by providing applications with rapid detection, high sensitivity and specificity. Associated with advances in biochemistry, biotechnology, electronics and microfabrication, new transduction devices that translate a biological interaction into an electrical signal have been developed. An overview of the current immunoassay techniques used in s… Show more

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Cited by 40 publications
(20 citation statements)
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“…This assay involves the use of a receptor (mostly an antibody), a disease specific antibody and a transducer that converts a biological interaction into a measurable signal (Cruz et al, 2002). These biosensors are frequently coupled to sophisticated instrumentation to produce highly-specific analytical tools, most of which are still in use only for the research and development purpose due to the high cost of instrumentation, high cost of individual sample analysis, and the need for highly trained persons to oversee the testing.…”
Section: Biosensorsmentioning
confidence: 99%
“…This assay involves the use of a receptor (mostly an antibody), a disease specific antibody and a transducer that converts a biological interaction into a measurable signal (Cruz et al, 2002). These biosensors are frequently coupled to sophisticated instrumentation to produce highly-specific analytical tools, most of which are still in use only for the research and development purpose due to the high cost of instrumentation, high cost of individual sample analysis, and the need for highly trained persons to oversee the testing.…”
Section: Biosensorsmentioning
confidence: 99%
“…Immunosensors are based on the immunochemical reaction comprising antigen or antibody as the recognition element, which is spatially in contact with a transducer surface [42]. Immunosensor‐based devices can be used to detect immunocomplex formation by measuring changes in resistance, current, refractive index, capacitance, etc.…”
Section: Microfluidics‐based Biosensors For Poc Diagnosticsmentioning
confidence: 99%
“…Specificity arises from the molecular recognition of target analytes by antibodies to form a stable complex on the immunosensor surface [1,2]. On the other hand, sensitivity depends on several factors including the use of high affinity analyte-specific antibody(ies), their orientation after being immobilized on the immunosensor surface and the appropriate detection system for measurement of the signal generated via a transducer [3]. Many types of immunosensors have been developed according to the mode of detection.…”
Section: Introductionmentioning
confidence: 99%