Immunosensing platform based on gallium nanoparticle arrays on silicon substrates

Marín, Antonio García; Hernández, María Jesús; Ruiz, Elena María Villamor; Abad, José M.; Lorenzo, Encarnación; Piqueras, J.; Pau, J. L.

doi:10.1016/j.bios.2015.08.002

Cited by 31 publications

(25 citation statements)

References 45 publications

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“…For that reason, this work investigates the functionalization of the GaNPs/graphene surface using a bifunctional reagent, DTSP. Our previous works have shown the chemical modification of GaNPs on Si substrates using this molecule . The adsorption mechanism is similar to that found in Au surfaces, where the disulfide undergoes dissociative chemisorption to give rise to the corresponding adsorbed thiolates.…”

Section: Chemical Modificationsupporting

confidence: 57%

“…Unlike GaNPs/Si sample, the surface modification of the GaNPs/graphene/SiO 2 /Si sample produces a significant variation of the dip energy in the Psi function toward larger energies. The low variation observed in the GaNPs/Si system does not mean that the chemical modification is unsuccessful since evidence of the CO vibrations has been found in FTIR analysis . However, the result proves that GaNPs/graphene systems can improve the sensitivity of the ellipsometric plasmonic sensors based on GaNPs by optimizing the chemical modification process on the base of the GaNPs where the in‐plane plasmonic resonances maximize the optical electric field.…”

Section: Chemical Modificationmentioning

confidence: 91%

“…The affinity between Ga and S enables the interaction between Ga and bifunctional agents, containing thiols and reactive groups for the immobilization of amino‐containing biomolecules. These immobilization protocols are similar to those used on Au surfaces .…”

Section: Introductionmentioning

confidence: 99%

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Optical biosensing platforms based on Ga-graphene plasmonic structures on Cu, quartz and SiO₂/Si substrates

Pau

Marín

Hernández

et al. 2016

Phys. Status Solidi B

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Ga nanoparticles (GaNPs) produced by thermal evaporation or epitaxial methods on graphene sheets present strong plasmonic effects that can couple to graphene phonons. In this work, GaNPs are deposited on graphene monolayers supported on Cu, quartz, and SiO2/Si substrates. The use of graphene increases the interparticle distance and improves the size uniformity. The enhancement of G and 2D graphene Raman lines is analyzed for the different substrates under excitation at 633 and 532 nm. The plasmonic effects are investigated using spectroscopic ellipsometry, finding a strong resonant mode at energies between 1.7 and 2.0 eV and an incidence angle of 55.6°. Finally, the heterogeneous surfaces are functionalized for the preparation of optical biosensors exposing the surface to 3,3′‐dithiodipropionic acid di(N‐succinimidyl ester) (DTSP). A significant energy shift of the ellipsometric signal on the Ga/graphene surfaces is observed in comparison to Ga/Si surfaces. Sketch of GaNPs atop graphene and biofunctionalizing agent (DTSP). Dip in the Psi ellipsometric function, and associated step in the Delta function, found around the GaNPs–graphene coupling resonance at an incident angle of 55.6°.

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Section: Chemical Modificationsupporting

confidence: 57%

Section: Chemical Modificationmentioning

confidence: 91%

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Optical biosensing platforms based on Ga-graphene plasmonic structures on Cu, quartz and SiO₂/Si substrates

Pau

Marín

Hernández

et al. 2016

Phys. Status Solidi B

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“…surface enhanced Raman spectroscopy (SERS) [27][28][29] , surface enhanced fluorescence 30,31 , Li-ion batteries 32 , waveguiding 33,34 , optical switching 35,36 , phase-change memories 37 or the development of biosensors for the detection of different diseases 38,39 .…”

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confidence: 99%

Plasmonic coupling in closed-packed ordered gallium nanoparticles

Catalán‐Gómez

Bran

Vázquez

et al. 2020

Sci Rep

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plasmonic gallium (Ga) nanoparticles (nps) are well known to exhibit good performance in numerous applications such as surface enhanced fluorescence and Raman spectroscopy or biosensing. However, to reach the optimal optical performance, the strength of the localized surface plasmon resonances (LSPRs) must be enhanced particularly by suitable narrowing the NP size distribution among other factors. With this purpose, our last work demonstrated the production of hexagonal ordered arrays of Ga NPs by using templates of aluminium (Al) shallow pit arrays, whose LSPRs were observed in the VIS region. The quantitative analysis of the optical properties by spectroscopic ellipsometry confirmed an outstanding improvement of the LSPR intensity and full width at half maximum (FWHM) due to the imposed ordering. Here, by engineering the template dimensions, and therefore by tuning Ga NPs size, we expand the LSPRs of the Ga NPs to cover a wider range of the electromagnetic spectrum from the UV to the IR regions. More interestingly, the factors that cause this optical performance improvement are studied with the universal plasmon ruler equation, supported with discrete dipole approximation simulations. the results allow us to conclude that the plasmonic coupling between nps originated in the ordered systems is the main cause for the optimized optical response. The interaction between metallic nanoparticles (NPs) and the electromagnetic radiation has constituted the driving force for the studies of the light-matter interaction during the last decades 1-3. Due to their free electrons, the metallic NPs are capable to concentrate and amplify the electric near-field in the vicinities of their surfaces. The electron oscillations (plasmons) resonate with light at a certain frequency that is commonly known as the localized surface plasmon resonance (LSPR). This frequency strongly depends on the NP size, shape, contact angle, environment and, especially, on the metal type 4. For instance, in the most studied elements, silver (Ag) and gold (Au), their LSPRs are quite restricted to the visible (VIS) region 5 due to their low losses and interband transitions in the ultraviolet (UV) region. Thus, during the last years, there has been an effort in the scientific community to search for alternative metals 6-8. Among others, liquid gallium (Ga) has emerged as an ideal plasmonic candidate 9,10 since its LSPRs can be tuned from the UV to the infrared (IR) due to the lack of strong interband transitions in this wide region 11 in contrast to other candidates such as Al 12 , Cu 13 or Ni 14. This spectral tunability can be achieved by means of different methods: changing the NP size 15 , contact angle or substrate 16,17 , varying the gallium oxide shell thickness 18 , by hybridization with other plasmonic NPs 19 or by alloying 9,20. In addition to this, the Ga NPs can be grown in a facile, fast and up-scalable method such as Joule-effect thermal evaporation 21,22. This synthesis technique produces self-assembled hemispherical NPs formed by a liquid G...

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“…Regarding biosensing, our group has been widely investigating the detection of different biomolecules such as glutathione 15 , Helicobacter pylori and specific gene mutation related to disease such as cystic fibrosis 16 . These works analyzed the optical properties of the Ga NPs by spectroscopic ellipsometry (SE) before and after the functionalization.…”

Section: Introductionmentioning

confidence: 99%

The role of the oxide shell in the chemical functionalization of plasmonic gallium nanoparticles

Catalán‐Gómez

Briones

Redondo-Cubero

et al. 2017

Optical Sensors 2017

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Plasmonic Ga nanoparticles (NPs) were thermally oxidized at low temperature in order to increase the native Ga 2 O 3 shell thickness and to improve their stability during the chemical functionalization. The optical, structural and chemical properties of the oxidized NPs have been studied by spectroscopic ellipsometry, scanning electron microscopy, grazing incidence X-ray diffraction and X-ray photoelectron spectroscopy. A clear redshift of the peak wavelength is observed with the increasing annealing time due to the Ga 2 O 3 thickness increase, and barely affecting the intensity of the plasmon resonance. This oxide layer enhances the stability of the NPs upon immersion in ethanol or water. The surface sensitivity properties of the as-grown and oxidized NPs were investigated by linking a thiol group from 6-Mercapto-1-hexanol through immersion. Ellipsometric spectra at the reversal polarization handedness (RPH) condition are in agreement with the Langmuir absorption model, indicating the formation of a thiol monolayer on the NPs.

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Immunosensing platform based on gallium nanoparticle arrays on silicon substrates

Abstract: Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in:Biosensors and Bioelectronics 74 (2015)

Cited by 31 publications

References 45 publications

Optical biosensing platforms based on Ga-graphene plasmonic structures on Cu, quartz and SiO₂/Si substrates

Optical biosensing platforms based on Ga-graphene plasmonic structures on Cu, quartz and SiO₂/Si substrates

Plasmonic coupling in closed-packed ordered gallium nanoparticles

The role of the oxide shell in the chemical functionalization of plasmonic gallium nanoparticles

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Immunosensing platform based on gallium nanoparticle arrays on silicon substrates

Abstract: Esta es la versión de autor del artículo publicado en: This is an author produced version of a paper published in:Biosensors and Bioelectronics 74 (2015)

Cited by 31 publications

References 45 publications

Optical biosensing platforms based on Ga-graphene plasmonic structures on Cu, quartz and SiO2/Si substrates

Optical biosensing platforms based on Ga-graphene plasmonic structures on Cu, quartz and SiO2/Si substrates

Plasmonic coupling in closed-packed ordered gallium nanoparticles

The role of the oxide shell in the chemical functionalization of plasmonic gallium nanoparticles

Contact Info

Product

Resources

About

Optical biosensing platforms based on Ga-graphene plasmonic structures on Cu, quartz and SiO₂/Si substrates

Optical biosensing platforms based on Ga-graphene plasmonic structures on Cu, quartz and SiO₂/Si substrates