Immunoscintigraphy and intra‐operative radioimmunodetection in the treatment of colorectal carcinoma

Hladík, P; Vízda, J; Bedrna, J; Simkovĭc, D; Strnad, Ladislav; Šmejkal, Karel; Voboril, Z

doi:10.1046/j.1463-1318.2001.00275.x

Cited by 15 publications

(14 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The examination can be influenced by subjective error. Our team has gained experience from a previous project in which we tested intraoperative radioimmunodetection using a hand-held gamma probe [21]. Some authors recommend separating the mesorectum from the rectum.…”

Section: Discussionmentioning

confidence: 99%

Radio-guided sentinel node detection during the surgical treatment of rectal cancer

Hladík

Vízda²,

D³

et al. 2005

Nuclear Medicine Communications

View full text Add to dashboard Cite

The scintigraphic method of detection of sentinel nodes in total mesorectal excision is not therapeutic, but diagnostic, and demonstrates a high level of reliability. It can be used to indicate the nodes that should be examined to detect the presence of possible micrometastases immunohistochemically. However, this method cannot be used for all detected nodes as it is very demanding. In the evaluated group of patients, there were no intraoperative or postoperative complications caused by this diagnostic method.

show abstract

Section: Discussionmentioning

confidence: 99%

Radio-guided sentinel node detection during the surgical treatment of rectal cancer

Hladík

Vízda²,

D³

et al. 2005

Nuclear Medicine Communications

View full text Add to dashboard Cite

show abstract

“…Radiolabeled antibodies have been used for imaging numerous malignancies, including hematological (23-26), colorectal (27)(28)(29), ovarian (33,34), and breast (36) tumors. This technology may also prove useful for pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Radiolabeled antibodies specific for various tumor antigens have demonstrated their utility as imaging agents for hematological tumors (23)(24)(25)(26), as well as for colorectal (27)(28)(29), medullary thyroid (30,31), bladder (32), ovarian (33,34), prostate (35), and breast cancers (36), among others. More recently, pretargeting methodologies have received a great deal of attention for imaging and therapy of cancer (37).…”

Section: Introductionmentioning

confidence: 99%

Improved Targeting of Pancreatic Cancer

Karacay

Goldenberg

Yeldell

et al. 2004

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose:The early detection and diagnosis of pancreatic cancer remains a major clinical challenge in which imaging procedures have a central role. The purpose of this study was to evaluate a pretargeting method with a bispecific PAM4 (bsPAM4; anti-MUC1) antibody for radioimmunoscintigraphy of experimental human pancreatic cancer.Experimental Design: A bispecific F(ab) 2 antibody was generated from chimeric PAM4 Fab and murine 734 (antiindium-diethylenetriaminepentaacetic acid) Fab fragments and then used in conjunction with 2 peptide haptens ( 111 In-IMP-156 and 99m Tc-IMP-192). Biodistribution studies and radioimmunoscintigraphic imaging properties of the radiolabeled bsPAM4, and pretargeted, radiolabeled peptides were examined in the CaPan1 human pancreatic tumor grown as s.c. xenografts in athymic nude mice. Tumor uptake and tumor:nontumor ratios were compared with a nontargeting irrelevant anti-CD20, bispecific rituximab, radiolabeled peptides alone, and with directly labeled PAM4.Results Conclusions: These studies demonstrate the feasibility of using the pretargeted, bispecific antibody technology for nuclear imaging of pancreatic cancer. The advantage of pretargeted bsPAM4 antibody as an imaging platform is the high specificity for pancreatic cancer as compared with the physicochemical parameters identified by current imaging technologies.

show abstract

“…Future improvements in the understanding of cancer biology, but also combination of imaging techniques with biochemical tracers for investigating prognostic relevant factors may alter the mode and accuracy of staging, even for lymph nodes. Radioimmunoguided surgery has been entertained in sporadic reports over the last decade [102,103,104,105,106,107], also in combination with sentinel node biopsy or other technologies, yet it has not found its place in routine clinical practice with currently available technologies. Intraoperative fluorescence, using naturally fluorescent biomarkers or fluorescent tumor probes, probably offers the most practical means of intraoperative lymph node staging and may be facilitated by using nanotechnology [107].…”

Section: Conclusion and Future Strategiesmentioning

confidence: 99%

Qualitative and Quantitative Issues of Lymph Nodes as Prognostic Factor in Colon Cancer

Veen¹,

Nedrebø²,

Stormark³

et al. 2013

Dig Surg

View full text Add to dashboard Cite

For patients undergoing curative resections for colon cancer, the nodal status represents the strongest prognostic factor, yet at the same time the most disputed issue as well. Consequently, the qualitative and quantitative aspects of lymph node evaluation are thus being scrutinized beyond the blunt distinction between ‘node positive' (pN+) and ‘node negative' (pN0) disease. Controversy ranges from a minimal or ‘least-unit' strategy as exemplified by the ‘sentinel node' to a maximally invasive or ‘all inclusive' approach by extensive surgery. Ranging between these two extremes of node sampling strategies are factors of quantitative and qualitative value, which may be subject to modification. Qualitative issues may include aspects of lymph node harvest reflected by surgeon, pathologist and even hospital performance, which all may be subject to modification. However, patient's age, gender and genotype may be non-modifiable, yet influence node sample. Quantitative issues may reflect the balance between absolute numbers and models investigating the relationships of positive to negative nodes (lymph node ratio; log odds of positive lymph nodes). This review provides an updated overview of the current controversies and a state-of-the-art perspective on the qualitative and quantitative aspects of using lymph nodes as a prognostic marker in colon cancer.

show abstract

Immunoscintigraphy and intra‐operative radioimmunodetection in the treatment of colorectal carcinoma

Cited by 15 publications

References 16 publications

Radio-guided sentinel node detection during the surgical treatment of rectal cancer

Radio-guided sentinel node detection during the surgical treatment of rectal cancer

Improved Targeting of Pancreatic Cancer

Qualitative and Quantitative Issues of Lymph Nodes as Prognostic Factor in Colon Cancer

Contact Info

Product

Resources

About