Immunoregulation of mammalian fertility

Murdoch, William J.

doi:10.1016/0024-3205(94)00519-2

Cited by 15 publications

(7 citation statements)

References 254 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…There are reports of the presence of a factor similar to GCIF in pig (Kigawa et ah, 1986) and rat follicular fluid (Chakravorty et ah, 1991(Chakravorty et ah, ,1993 (Scaramuzzi and Hoskinson, 1984;Webb et ah, 1984), and the peptides, oxytocin (Wathes et ah, 1989) and inhibin (Morris et ah, 1991;Murdoch, 1994). Immunization against each of these factors has been shown to alter ovulation rate in sheep, but all of these factors differ from GCIF either in molecular weight, solubility properties or action on ovarian cells.…”

Section: Discussionmentioning

confidence: 99%

Immunization of rats and sheep against granulosa cell-inhibitory factor from bovine follicular fluid increases the number of large follicles in rats and the ovulation rate in sheep

Hynes

Kane²,

Sreenan³

1999

Reproduction

View full text Add to dashboard Cite

Granulosa cell-inhibitory factor (GCIF), a low molecular weight factor from bovine follicular fluid, inhibits the proliferation of bovine granulosa cells in vitro and the growth of large follicles in rats in vivo. In this study the effects of (1) immunization of rats against GCIF on follicular growth and (2) immunization of sheep against GCIF on ovulation rate were studied. The ability of antiserum from sheep immunized against GCIF to reduce the inhibitory effect of GCIF on bovine granulosa cell proliferation in culture was also examined. Immunization of rats against GCIF increased the number of large follicles (P < 0.001) but decreased the number of small follicles (P < 0.05) per ovary. Ovarian mass (P < 0.05) and uterine wet (P < 0.05) and dry (P < 0.01) masses were increased in immunized rats. Immunization of sheep against GCIF, followed by boosting over two breeding seasons, increased ovulation rate (P < 0.01). Addition of antiserum from sheep immunized against GCIF reduced or abolished the inhibitory effect of GCIF on granulosa cell proliferation (P < 0.01). These data provide further evidence that GCIF has an important role in controlling follicle growth and ovulation in vivo.

show abstract

Section: Discussionmentioning

confidence: 99%

Immunization of rats and sheep against granulosa cell-inhibitory factor from bovine follicular fluid increases the number of large follicles in rats and the ovulation rate in sheep

Hynes

Kane²,

Sreenan³

1999

Reproduction

View full text Add to dashboard Cite

show abstract

“…Considerable controversy exists regarding optimal methods for controlling feral cats, including what is most practical, effective, and humane [1]. Recently, interest has turned to immunocontraception for nonlethal control of ''pest'' species [2][3][4]. An ideal feline immunocontraceptive would have a high margin of safety for treated animals and the environment, be effective in a high percentage of treated animals, have a rapid onset and long duration of activity following a single treatment, inhibit sex hormone production, be efficacious in all animals regardless of sex or age, and be simple to deliver in the field.…”

Section: Introductionmentioning

confidence: 99%

GnRH immunocontraception of male cats

et al. 2004

View full text Add to dashboard Cite

The development of nonsurgical contraceptives for cats may facilitate population control of the species. The purpose of this study was to investigate the utility of GnRH for immunocontraception of male cats. Male cats (n ¼ 12) were divided into groups of three and were immunized once with 0 (sham), 50, 200, or 400 mg synthetic GnRH coupled to keyhole limpet hemocyanin and combined with a mycobacterial adjuvant to enhance immunogenicity. GnRH antibody titer, serum testosterone concentration, and scrotal size were determined monthly. At 6 months, semen was collected by electroejaculation and testes were examined histologically. GnRH antibodies were detected in all cats receiving GnRH vaccine by 1 month post-treatment and persisted throughout the study. No dose effect of GnRH was observed; titers were not different among cats treated with 50, 200, or 400 mg GnRH (P ¼ 0:5). Six of nine treated cats were classified as responders based on high GnRH antibody titers (>32,000). By 3 months post-treatment, responder cats had undetectable testosterone concentrations and testicular atrophy. Nonresponder cats had GnRH titers of 4000-32,000 and testosterone concentrations intermediate between responder and sham-treated cats. At 6 months, total sperm counts were similar for sham-treated cats (3:1 AE 1:8 Â 10 6 sperm) and nonresponder cats (3:4 AE 1:6 Â 10 6 sperm; P ¼ 0:7). Only one of the six responder cats produced sperm, none of which were motile. Combined testicular weights of responder cats (1:3 AE 0:1 g) were lower than sham-treated controls (5:3 AE 1:3 g; P ¼ 0:02) and nonresponder cats (2:9 AE 0:3 g; P ¼ 0:02). Histologic evaluation of the testes revealed that in responder cats, the interstitial cells that were present were pale and shrunken compared to the plump, polyhedral eosinophilic cells in sham-treated cats. GnRH responder cats had marked

show abstract

“…As seen in Figure 1, as GnRH stimulates secretion of gonadotropic hormones, it is logical that the immunoneutralization of GnRH would prevent endogenous GnRH from binding to its receptors and cause gonadal atrophy in adults, such as sprematogenic arrest and libido loss. 94 Several attempts have been made to couple mammalian GnRH, a nonimmunogenic peptide, to carrier proteins such as tetanus and diphtheria toxoids to enhance the bioefficacy of the antibodies produced. 95 Anti-GnRH vaccines have been tested for control of prostate cancers in India, in hopes of cutting off androgen support to prostate cancer cells.…”

Section: Gnrh/gonadotropin Vaccinesmentioning

confidence: 99%

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti

Honig

2010

Int J Impot Res

View full text Add to dashboard Cite

Traditionally, male contraception has consisted of either barrier methods, such as condoms, or vasectomy. However, in recent years, we have made great strides in the basic science and clinical medicine to better understand the feedback mechanisms and physiology of the male reproductive system. These advances have enabled the development of several nonsurgical, hormonal, reversible, well-tolerated alternatives for male contraception. Men are more likely now than ever to participate in the choice of contraceptive techniques. This review will discuss the current status and recent developments in nonsurgical hormonal male contraception, a field that has been historically limited by social, financial and physiological challenges.

show abstract

Immunoregulation of mammalian fertility

Cited by 15 publications

References 254 publications

Immunization of rats and sheep against granulosa cell-inhibitory factor from bovine follicular fluid increases the number of large follicles in rats and the ovulation rate in sheep

Immunization of rats and sheep against granulosa cell-inhibitory factor from bovine follicular fluid increases the number of large follicles in rats and the ovulation rate in sheep

GnRH immunocontraception of male cats

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Contact Info

Product

Resources

About