Immunoreactivity of granular cell lesions of skin, mucosa, and jaw

Regezi, Joseph A.; Zarbo, Richard J.; Courtney, Richard M.; Crissman, John D.

doi:10.1002/1097-0142(19891001)64:7<1455::aid-cncr2820640716>3.0.co;2-#

Cited by 52 publications

(16 citation statements)

References 23 publications

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“…23 However, two studies did not find the expression of vimentin in the granular cells of ameloblastomas. 21,37 Although the immunuhistochemical findings appear to support the aging phenomenon of the granular cells in ameloblastomas, it has to be aware that the role of replicative senescence in the aging process remains controversial. 38 For example, there seems to be no clear link between telomerase repeat number and donor age in certain cell type.…”

Section: Discussionmentioning

confidence: 99%

Investigation of basement membrane proteins in a case of granular cell ameloblastoma

2012

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Granular cell ameloblastoma is a rare, benign neoplasm of the odontogenic epithelium. A case of massive granular cell ameloblastoma in a 44-year-old Thai female is reported. Histopathological features displayed a follicular type of ameloblastoma with an accumulation of granular cells residing within the tumor follicles. After treatment by partial mandibulectomy, the patient showed a good prognosis without recurrence in a 2-year follow-up. To characterize the granular cells in ameloblastoma, we examined the expression of basement membrane (BM) proteins, including collagen type IV, laminins 1 and 5 and fibronectin using immunohistochemistry. Except for the granular cells, the tumor cells demonstrated a similar expression of BM proteins compared to follicular and plexiform ameloblastomas in our previous study, whereas the granular cells showed strong positivity to laminins 1 and 5 and fibronectin. The increased fibronectin expression in granular cells suggests a possibility of age-related transformation of granular cells in ameloblastoma.

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Section: Discussionmentioning

confidence: 99%

Investigation of basement membrane proteins in a case of granular cell ameloblastoma

2012

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“…Later studies, however, showed that this antibody recognizes a 110-kDa lysosomal protein, which can be found in various histiocytic and nonhistiocytic tumors that are rich in lysosomes [105,121] ; therefore, KP1 immunostaining is not useful in the diagnosis of GCT. Positivity for a1-antichymotrypsin in GCTs has been reported [105,108], but this marker, like CD68, is not specific for GCT.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Granular Cell Tumor: A Review of the Pathology and Histogenesis

Ordóñez

Mackay²

1999

Ultrastructural Pathology

169

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As the name suggests, the histogenesis of the granular cell tumor is uncertain, but this intriguing neoplasm has occasioned much speculation and controversy since its description in 1926 as a myoblastoma. Though ubiquitous in its anatomic location, it is usually small, solitary, benign, and readily recognized by routine light microscopy, and questions concerning it are principally academic. However, a small number of cases are malignant and they can be difficult to identify in paraffin sections. The combined input from immunohistochemistry and electron microscopy has greatly clarified understanding of the morphology of this lesion and both methods are helpful when the differential diagnosis is a problem. The cell of origin is still undecided, and although distinct neural features argue for Schwannian origin, the noncommittal term granular cell tumor continues to be appropriate.

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“…Although these tumors share a common neural origin, they exhibit notable microscopic and pathogenetic heterogeneity. [61][62][63][64][65][66][67][68] …”

Section: Clinical Characteristicsmentioning

confidence: 99%