Immunophenotyping of T cells in the peripheral circulation in psoriasis

Priyadarssini, M.; Priya, Dhivya; Indhumathi, S; Rajappa, Medha; Chandrashekar, Laxmisha; Thappa, Devinder Mohan

doi:10.1080/09674845.2016.1207869

Cited by 42 publications

(35 citation statements)

References 35 publications

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“…Our earlier report described higher percentages of Th1 and Th17 cells and lower percentages of Th2 and Treg cells in the psoriasis group compared with the HC group . There was a predominance of Th1 and Th17 cell populations both in the skin and circulation of patients with psoriasis, which was further supported by the diminished anti‐inflammatory response mounted by Th2 and Treg cells . MTX decreases recruitment of inflammatory cells, increasing the apoptosis of activated T cells.…”

Section: Discussionmentioning

confidence: 76%

“…This was a hospital‐based cohort study at Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India. Of the 189 patients with psoriasis recruited for our previous study, 50 patients aged 18–60 years with moderate to severe psoriasis [Psoriasis Area and Severity Index (PASI) > 10] diagnosed according to the International Psoriasis Council Consensus Classification of Psoriasis were enrolled in the study. In addition, 50 healthy volunteers were recruited for the HC group.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, changes in the numbers and functions of different subsets of T cells might have a notable role in the disease pathogenesis. In our earlier report, we assessed the Th/Treg cell pattern in the peripheral circulation of 189 patients with psoriasis and found a dysregulated T‐cell immunophenotype, with an elevation in Th1/Th17 cells and a relative depression in Th2/Treg cells in patients with psoriasis compared with healthy controls (HCs).…”

Section: Introductionmentioning

confidence: 99%

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Effect of methotrexate monotherapy on T‐cell subsets in the peripheral circulation in psoriasis

Priyadarssini¹,

Chandrashekar²,

Rajappa³

2018

Clin Exp Dermatol

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Background. Psoriasis is a T-helper (Th)1/Th17-mediated chronic inflammatory disease. There is an increased population of Th cells in skin lesions and peripheral circulation of patients with psoriasis. Systemic methotrexate (MTX) is an effective treatment for moderate to severe psoriasis; however, its effect on different T-cell subsets is not yet clear. Aim. To study the effect of MTX monotherapy on the psoriatic T-cell profile in the peripheral circulation of patients with psoriasis.Methods. This was a follow-up study involving 50 patients with moderate to severe psoriasis treated with systemic MTX for 12 weeks. Blood samples (5 mL) were collected from participants, from which PBMCs were isolated, and T-cell phenotyping was performed by flow cytometry. Results. Following 12 weeks of MTX treatment, there was an increase in the percentages of Th2/Treg cells, and a relative decrease in the percentages of Th1/Th17 cells, along with a significant reduction in the median Psoriasis Area and Severity Index (PASI). Conclusion. MTX helps in the restoration of the immune balance by decreasing the numbers of Th1 and Th17 cells and increasing the numbers of Th2 and Treg cells, thus resulting in a significant reduction in disease severity. MTX converts a proinflammatory T-cell phenotype to a protective anti-inflammatory phenotype, thus significantly suppressing the inflammation in psoriasis.

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Section: Discussionmentioning

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of methotrexate monotherapy on T‐cell subsets in the peripheral circulation in psoriasis

Priyadarssini¹,

Chandrashekar²,

Rajappa³

2018

Clin Exp Dermatol

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“…Psoriasis is a relatively common autoimune disease characterised by leukocyte infiltration into the skin. In a well-powered study of 189 cases and an equal number of controls, Priyadarssinia et al [27] provide data in support of the hypothesis that changes in certain T lymphocyte subsets (Th1/Th17) have a role in the pathogenesis of this disease, as indicated by a link with disease severity (e.g. r < 0.75, p < 0.001).…”

Section: Clinical Chemistrymentioning

confidence: 64%

British Journal of Biomedical Science in 2016. What have we learned?

Blann

2017

British Journal of Biomedical Science

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In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities. The present report will summarise key aspects of these publications that are of greatest relevance to laboratory scientists.

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“…Priyadarssini et al . also reported that interaction between T cell and KC can give rise to overproliferation of KC, which results in further psoriasis inflammation …”

Section: Discussionmentioning

confidence: 99%

Levels of miR‐31 and its target genes in dermal mesenchymal cells of patients with psoriasis

Wang¹,

Chang²,

Yang³

et al. 2018

Int J Dermatology

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Immunophenotyping of T cells in the peripheral circulation in psoriasis

Abstract: Our results suggest an immune-dysregulation in psoriasis associated with a predominance of Th1/Th17 phenotype, especially with increasing severity of the disease.

Cited by 42 publications

References 35 publications

Effect of methotrexate monotherapy on T‐cell subsets in the peripheral circulation in psoriasis

Effect of methotrexate monotherapy on T‐cell subsets in the peripheral circulation in psoriasis

British Journal of Biomedical Science in 2016. What have we learned?

Levels of miR‐31 and its target genes in dermal mesenchymal cells of patients with psoriasis

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