Immunophenotypical Characterization of a Brazilian POIS (Post-Orgasmic Illness Syndrome) Patient: Adding More Pieces to Puzzle

Lima, Karine De Amicis; Costa, Priscilla R.; Figo, Daniele Danella; Lima, Cynthia Mafra Fonseca de; Castro, Fábio Fernandes Morato; Kalil, Jorge; Santos, Keity Souza; Galvão, Clóvis Eduardo Santos

doi:10.1080/0092623x.2019.1677835

Cited by 8 publications

(1 citation statement)

References 16 publications

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“…This ion channel microinjury was hypothesized based on a strange medical condition called post-orgasmic illness syndrome (POIS), which has an unknown pathomechanism where the underlying damaging mechanism was suspected to be analogous with DOMS but in a chronic way [ 18 ]. One case study excluded that POIS was a hypersensitivity reaction and found a diminished number of CD56 dim CD16 + natural killer (NK) cells [ 19 ]. Furthermore, some articles suggested an analogous underlying non-contact microinjury mechanism of the muscle spindle-derived proprioceptive terminals in DOMS and amyotrophic lateral sclerosis (ALS), as well [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

CD3+/CD56+ NKT-like Cells Show Imbalanced Control Immediately after Exercise in Delayed-Onset Muscle Soreness

Sonkodi

Pállinger

Radovits

et al. 2022

IJMS

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The purpose of the study was to carry out an immunophenotypical characterization with a special focus on natural killer cells of junior swimmers from the Hungarian National Swim Team before and after an intensive acute exercise. Nineteen swimmers, ten females and nine males, completed the exercise protocol. Sixteen swimmers experienced delayed-onset muscle soreness. Most of our findings substantiated earlier results, such as the increase in the percentage of the CD3−/CD56+ natural killer cells and the CD3−/CD56dim+ NK cells, and the decrease in the percentage of CD3+ T cells among lymphocytes after the exercise protocol. The drop of natural killer cell activity back to the pre-exercise level was in line with earlier findings. Interestingly, the percentage of CD3+/CD56+ NKT-like cells did not change significantly in those three swimmers who did not report delayed-onset muscle soreness. On the contrary, the percentage of CD3+/CD56+ NKT-like cells among lymphocytes increased in fourteen and decreased in two swimmers reporting delayed-onset muscle soreness. This study for the first time demonstrated a link between the delayed-onset muscle soreness and the imbalanced control of CD3+/CD56+ NKT-like cells among lymphocytes. However, validation of this association in a larger sample size study will be necessary.

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