Immunophenotypic characterization of human fetal liver hematopoietic stem cells during the midtrimester of gestation

Gemtuzumab ozogamicin (Mylotarg) monotherapy for relapsed AML after hematopoietic stem cell transplant: efficacy and incidence of hepatic veno-occlusive disease

“…While the CD33 antigen can be expressed in the liver on hematopoietic progenitors during fetal development, [23][24][25] it has not been found on adult hepatocytes or on the sinusoidal endothelial cells (SEC) thought to be the initial target of injury in VOD. 8,26 Neither VOD nor significant hepatotoxicity have been described with other anti-CD33 monoclonal antibodies, either unlabeled or radiolabeled, used in human studies.…”

Expression of Adhesion Molecules on CD34 + Cells in Peripheral Blood of Non‐Hodgkin's Lymphoma Patients Mobilized with Different Growth Factors

“…+ [24][25][26][27][28] and CD34 + cells coexpressing adhesion molecules such as CD62L (L-selectin) and CD49d (VLA-4) were the most studied [32][33][34][35][36][37][38]. Yet, the factors involved in the regulation of stem cell release from the BM to the circulation and the mechanism of homing are still poorly understood.…”

Hemopoietic progenitor cell identification in fetal and adult blood

“…It has been reported previously the presence of the CD34 molecule on hemopoietic cells from human fetal liver; the number of molecules in the surface of these cells is greater than on hemopoietic cells of the adult. 15,16 Hemopoietic progenitor cells have been identified as early as the 23 th day of gestation in the yolk sac and in embryonic tissues. Hemopoietic islands are observed in the lumen of the primitive vessels in the yolk sac wall and CD34+ cells can be detected also in the ventral region of the dorsal aorta around the pre umbilical region.…”

“…1,2,3 During the development of the human embryo and fetus, the first blood cells appear in the yolk sac by 16 to 19 days after conception; by 5-6 week, hematopoiesis is occurring mainly in the liver and by [8][9][10][11][12][13][14][15][16][17][18][19] weeks in the bone marrow of long bones. 4 At the beginning of liver hematopoiesis (5-6 weeks of gestation), most of the cells present in hepatic sinusoids are primitive erythroblasts.…”