Immunophenotype of Nipple Adenoma in a Male Patient

Fernández-Flores, Ángel; Suarez-Peñaranda, Jose-Manuel

doi:10.1097/pai.0b013e3181f1ef0b

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…There is no consensus on the immunohistochemical pro le of NA, especially regarding ER PR and HER2 status. Angel Fernandez-Flores suggested in his study that the immunophenotype of male NA is similar to that of females, with ER and PR being negative [9], but our study showed that the inner epithelial cells were ER and PR positive. In the outer myoepithelial cells, P63, smooth muscle myosin, calponin (SMA), and CK5/6 were positive, aiding in the differentiation from malignant tumors [5,6].…”

Section: Discussioncontrasting

confidence: 78%

Nipple adenoma in prepubescent boy：a case report and review

Chen,

Xia,

Chen

et al. 2024

Preprint

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Background：Nipple adenoma is a rare benign nipple tumor that is seldom seen in males and can be challenging to differentiate from Paget's disease. Case report：We report the case of a boy with nipple adenoma who was initially misdiagnosed with Syringocystadenoma papilliferum combined with a tubular apocrine adenoma. Six months post-diagnosis, a nipple-areolar resection was conducted, followed by a purse-string suture technique to restore and reshape the nipple's appearance. Histopathological examination confirmed the diagnosis of nipple adenoma. Conclusion：Nipple adenomas often prove difficult to alleviate without surgical intervention; surgical excision is deemed the gold standard for treatment. It is vital to establish a clear pathological diagnosis for nipple adenomas, as they are benign tumors, to prevent unnecessary overtreatment.

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Section: Discussioncontrasting

confidence: 78%

Nipple adenoma in prepubescent boy：a case report and review

Chen,

Xia,

Chen

et al. 2024

Preprint

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“…It has been defined as erosive adenomatosis of the nipple, papillary AN, florid adenomatosis, florid papillomatosis of the nipple, subareolar duct papillomatosis and superficial papillary adenomatosis of the nipple (2,8,12). Since the main feature common to these lesions is adenomatous proliferation in the stroma (small and medium caliber duct proliferation) (1,4), the definition of AN was preferred in the current study.…”

Section: Discussionmentioning

confidence: 99%

“…It generally occurs unilaterally and arises at an average age of between 43–45 years, predominantly in females and rarely in males and adolescents (1–3). The lesion, also known as erosive adenoma and florid papillomatosis, appears similar to a hard-elastic nodule that deforms the nipple, causing swelling or erosion with serous or hematic secretion.…”

Section: Introductionmentioning

confidence: 99%

Adenoma of the nipple: A clinicopathological report of 13 cases

et al. 2014

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Adenoma of the nipple (AN) represents a rare benign mammary proliferation of lactiferous ducts. It appears as an erosive or ulcerative lesion, which in a number of cases is associated with a serous/hematic secretion. AN may be clinically confused with Paget’s disease and histologically with invasive breast carcinoma or breast cancer precursor lesions. Therefore, the histological and immunophenotypic analysis is essential for the differential diagnosis. The present study describes the histopathological characteristics of a first case series of AN.

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“…For example, changes in the expression of certain myoepithelial markers such as CD10, p63, and M-actin were seen in nipple adenomas and other benign breast lesions compared to normal ductal tissue [4,16]. In previous case reports, changes in estrogen receptor and progesterone receptor immunoexpression were also reported in patients with nipple adenomas [17,18]. Although rare, it is important to take into account the possibility of benign tumor development, such as papillary adenomas of the nipple, when considering hormone therapy for perimenopausal women.…”

Section: Discussionmentioning

confidence: 91%

Growth of a Nipple Adenoma After Estrogen Replacement Therapy

Skaribas,

Tschen

2023

Cureus

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A nipple adenoma is an epithelial tumor of the lactiferous ducts, typically affecting women aged 50-60 years old. This case report discusses a 52-year-old woman who developed a papillary adenoma of the right nipple after initiating oral estrogen replacement therapy (ERT) for perimenopausal symptoms. A 4 mm punch biopsy and subsequent immunohistochemistry stain revealed the proliferation of ductal structures consistent with a papillary adenoma and tumor cells expressing estrogen receptors (ER) and progesterone receptors (PR). Despite their benign nature, nipple adenomas may exhibit alterations in immunophenotype, including ER and PR expression, which could lead to potential tumor growth in women undergoing these treatments. This case describes the first reported growth of a nipple adenoma in the context of estrogen replacement therapy, highlighting a potential risk of hormone therapy in promoting hyperproliferation of benign tumors such as nipple adenomas. When utilizing ERT, it is important to weigh the potential advantages and risks, as its application in the management of vasomotor symptoms during menopause may increase the risk of both breast cancer and benign proliferative breast diseases. These considerations underscore the need for individualized therapy when approaching perimenopausal and postmenopausal care.

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Immunophenotype of Nipple Adenoma in a Male Patient

Abstract: This case of adenoma of the nipple in a male shows an immunophenotype that is similar to the ones reported in female patients.

Cited by 10 publications

References 21 publications

Nipple adenoma in prepubescent boy：a case report and review

Nipple adenoma in prepubescent boy：a case report and review

Adenoma of the nipple: A clinicopathological report of 13 cases

Growth of a Nipple Adenoma After Estrogen Replacement Therapy

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