Adenoma of the nipple: A clinicopathological report of 13 cases

Bonito, Maurizio Di; Cantile, Monica; Collina, Francesca; D’Aiuto, Massimiliano; Liguori, Giuseppina; Cecio, Rossella De; Botti, Gerardo

doi:10.3892/ol.2014.2000

Cited by 42 publications

(78 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Histologically, NA can appear similar to other breast conditions (including syringomatous adenoma of the nipple, intraductal papilloma, adenomyoepithelioma, ductal carcinoma in situ, and invasive ductal carcinoma) as well as several dermatologic lesions (including syringoma of the skin, hidradenoma papilliferum, and syringocystadenoma papilliferum) [ 2 , 15 , 23 , 26 , 52 , 118 , 131 ]. The major histologic features of NAs are that they represent a ductal proliferation of glandlike structures within the stroma of the nipple, and generally have fairly well circumscribed borders but without encapsulation [ 8 , 15 , 23 , 26 , 52 , 118 ]. Sclerosis/fibrosis may distort glands, mimicking an invasive growth pattern.…”

Section: Discussion/reviewmentioning

confidence: 99%

Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin

et al. 2016

View full text Add to dashboard Cite

BackgroundNipple adenoma is a very uncommon, benign proliferative process of lactiferous ducts of the nipple. Clinically, it often presents as a palpable nipple nodule, a visible nipple skin erosive lesion, and/or with discharge from the surface of the nipple skin, and is primarily seen in middle-aged women. Resultantly, nipple adenoma can clinically mimic the presentation of mammary Paget’s disease of the nipple. The purpose of our current case report is to present a comprehensive review of the available data on nipple adenoma, as well as provide useful information to health care providers (including dermatologists, breast health specialists, and other health care providers) who evaluate patients with dermatologic conditions of the breast skin for appropriately clinically recognizing, diagnosing, and treating patients with nipple adenoma.Case presentationFifty-three year old Caucasian female presented with a one year history of erythema and induration of the skin of the inferior aspect of the right nipple/areolar region. Skin punch biopsies showed subareolar duct papillomatosis. The patient elected to undergo complete surgical excision with right central breast resection. Final histopathologic evaluation confirmed nipple adenoma. The patient is doing well 31 months after her definitive surgical therapy.ConclusionsSince nipple adenoma represents a benign proliferative process of the nipple, complete surgical excision is curative. However, the coexistence of nipple adenoma and ipsilateral or contralateral breast cancer is well reported in the literature. The potential for a direct causal link or association of nipple adenoma and breast cancer cannot be fully excluded.

show abstract

Section: Discussion/reviewmentioning

confidence: 99%

Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In studies conducted by Stormby and Bondeson, 6 Mazzara et al, 7 and Koss et al, 8 aspiration biopsy cytology revealed adenoma of the nipple. 12 When myoepithelial cells are not clearly detected in the cytological specimen, they should be examined using histopathology. First, a large number of cells were isolated from an aspiration biopsy cytology specimen.…”

Section: Discussionmentioning

confidence: 99%

“…The positivity of at least two markers is sufficient for diagnosis, such as p63, CK5/6, hcaldesmon, calponin-1, a-smooth muscle actin, and CD10, with p63 and CK5/6 serving as superior markers. 12 When myoepithelial cells are not clearly detected in the cytological specimen, they should be examined using histopathology. Adenoma of the nipple causes erosion, because of which discriminating it from Paget's disease becomes the primary clinical problem.…”

Section: Discussionmentioning

confidence: 99%

Cytologic features of nipple adenoma: A report of four cases of adenoma of the nipple

Ozaki

Mizukami

Kawahara

2015

Diagnostic Cytopathology

View full text Add to dashboard Cite

We report four cases of adenoma of the nipple, a rare benign epithelial benign tumor occurring under the nipple and areola. Clinically, erosion findings of the nipple require discrimination from Paget's disease. In addition, a mass found in the nipple warrants discrimination from ductal carcinoma. Two cases underwent aspiration biopsy cytology and the other underwent tumor imprint cytology, respectively, revealing a large number of epithelial cell populations in the necrotic background material. These large cell clusters had a papillary or sheet structure and exhibited decreased cell cohesiveness at the cluster part. In addition, small clusters and solitary epithelial cells were also present. Furthermore, a two-cell pattern comprising both duct epithelial and myoepithelial cells was observed in the cell clusters. Two other cases underwent nipple brush cytology, revealing a few small papillary clusters with isolated epithelial cells in the hemorrhagic background. The clusters appeared as benign duct proliferative lesions such as papilloma, papillomatosis, and adenosis. An accurate diagnosis warrants the recognition of regular nuclei with bland chromatin and myoepithelial cells and the identification of the lesion location.

show abstract

“…Patients with florid papillomatosis of the nipple usually present with a nipple discharge or small superficially located nodule in the nipple-areolar complex. [12][13][14][15] Often, there are associated inflammatory changes in the overlying skin of the nipple, which may be ulcerated and may suggest Paget disease clinically. Florid papillomatosis occurs in both sexes and over the entire age spectrum, including infancy.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Practical Considerations in Breast Papillary Lesions: A Review of the Literature

Agoumi¹,

Giambattista²,

Hayes

2016

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

show abstract

Adenoma of the nipple: A clinicopathological report of 13 cases

Cited by 42 publications

References 12 publications

Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin

Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin

Cytologic features of nipple adenoma: A report of four cases of adenoma of the nipple

Practical Considerations in Breast Papillary Lesions: A Review of the Literature

Contact Info

Product

Resources

About