Immunopharmacological actions of lumin. (II). Effect of lumin administration in NZB*NZW (B/W) F1 mice.

Sasaki, Yasuo; Nagai, Noriko; Okimura, Tsutomu

doi:10.1254/fpj.89.9

Cited by 4 publications

(4 citation statements)

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“…given by (5) and varying the Bkm and the A ~S . L I J simultaneously until a minimum RMS deviation between calculated and expenmental energy levels was found.…”

Section: [Sllimentioning

confidence: 99%

Energy levels and crystal field parameters of Nd³⁺and Er³⁺in LiRP₄O₁₂single crystals

Mazurak¹,

Gruber²

1992

J. Phys.: Condens. Matter

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The experimental Stark energy levels for the Nd"' and Er" in LiRP40,2 crystals were presented in our previous paper [13]. A crystal field analysis of these data is based on a Uamiitonian of C2 p i n t group symmetry, including J-mixing efJects. We find that the twinned G,c (C,) structure is consistent with all available experimental results. A Hamiltonian parametrized in monoclinic symmetry was used to describe the observed cryrtalfield splinings of Nd" and Er" in LiRP,O,>. Resulting RMS deviations between calculated and experimental levels range from 6.8 to 7.1 cm".

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“…given by (5) and varying the Bkm and the A ~S . L I J simultaneously until a minimum RMS deviation between calculated and expenmental energy levels was found.…”

Section: [Sllimentioning

confidence: 99%

Energy levels and crystal field parameters of Nd³⁺and Er³⁺in LiRP₄O₁₂single crystals

Mazurak¹,

Gruber²

1992

J. Phys.: Condens. Matter

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“…NK-4 is the common name of cryptocyanine O.A.1 (PubChem CID: 5489539) [ 17 ]. It has been studied for over 150 years in Japan and has been of research interest in biology and medicine [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. NK-4 exhibits a variety of biological activities, such as preventing IL-4-driven polarization to alternatively activated macrophages and inhibiting cancer cell proliferation, allergy, and inflammation, and thus has been used to treat cancer and virus infection [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has been studied for over 150 years in Japan and has been of research interest in biology and medicine [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. NK-4 exhibits a variety of biological activities, such as preventing IL-4-driven polarization to alternatively activated macrophages and inhibiting cancer cell proliferation, allergy, and inflammation, and thus has been used to treat cancer and virus infection [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. In addition, NK-4 acts as a significantly more potent radical scavenger than edaravone and ascorbate, especially for hydroxyl radicals, peroxy radicals, and superoxides [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Cyanine Dye NK-4 on Photoreceptor Degeneration in a Rat Model of Early-Stage Retinitis Pigmentosa

et al. 2021

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The present study aimed to evaluate the effects of NK-4 on the apoptosis of photoreceptors in a rat model of retinitis pigmentosa and explore the mechanism underlying anti-apoptosis activity. The Royal College of Surgeons (RCS) rats received an intravitreous injection of NK-4 solution in the left eye and vehicle control in the right eye. Apoptosis was detected by TUNEL method in frozen sections of the eyes. The retinal tissues of the rats were dissected for RNA-seq analysis. Functional and pathway enrichment analyses of differentially expressed genes (DEGs) were performed by using Metascape and DAVID software. The expression levels of DEGs were confirmed by real-time quantitative PCR (RT-qPCR). The number of apoptotic cells decreased in the outer nuclear layer (ONL) and the thickness of the ONL was significantly thicker in the retina of NK-4-injected eyes, compared with control eyes. Five DEGs were identified by RNA-seq analysis, and Hmox1, Mt1, Atf5, Slc7a11, and Bdh2 were confirmed to be up-regulated by RT-qPCR. Functional and pathway enrichment analysis of the up-regulated genes showed that anti-apoptosis effects of NK-4 in the retina of RCS rats may be related to the pathways of metal ion homeostasis, negative regulation of neuron death, response to toxic substance, and pigment metabolic process. We found a potential mechanism of NK-4, providing a new viewpoint for the development of more therapeutic uses of NK-4 in the future.

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“…NK-4 has a variety of biological activities, including antimicrobial [15], macrophage-activating [16], and anticancer properties, and is used as an immunomodulator in treatment with antiviral and anticancer agents [17]. NK-4 also has anti-inflammatory properties [18] and has been used to treat allergy [19].…”

Section: Introductionmentioning

confidence: 99%

Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease

et al. 2012

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Beta-amyloid (Aβ) peptides are considered to play a major role in the pathogenesis of Alzheimer's disease (AD) and molecules that can prevent pathways of Aβ toxicity may be potential therapeutic agents for treatment of AD. We have previously reported that NK-4, a cyanine photosensitizing dye, displays neurotrophic and antioxidant activities. In this study, we report the effects of NK-4 on the toxicity of Aβ and on cognitive function and Aβ concentration in a transgenic mouse model of AD (Tg2576). In vitro, NK-4 effectively protected neuronal cells from toxicity induced by Aβ. In addition, it displayed profound inhibitory activities on Aβ fibril formation. In vivo, Tg2576 mice received an intraperitoneal injection at 100 or 500 µg/kg of NK-4 once a day, five times a week for 9 months. Administration of NK-4 to the mice attenuated impairment of recognition memory, associative memory, and learning ability, as assessed by a novel object recognition test, a passive avoidance test, and a water maze test, respectively. NK-4 decreased the brain Aβ concentration while increasing the plasma amyloid level in a dose-dependent manner. NK-4 also improved memory impairments of ICR mice induced by direct intracerebroventricular administration of Aβ. These lines of evidence suggest that NK-4 may affect multiple pathways of amyloid pathogenesis and could be useful for treatment of AD.

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Immunopharmacological actions of lumin. (II). Effect of lumin administration in NZB*NZW (B/W) F1 mice.

Cited by 4 publications

References 0 publications

Energy levels and crystal field parameters of Nd³⁺and Er³⁺in LiRP₄O₁₂single crystals

Energy levels and crystal field parameters of Nd³⁺and Er³⁺in LiRP₄O₁₂single crystals

The Effect of Cyanine Dye NK-4 on Photoreceptor Degeneration in a Rat Model of Early-Stage Retinitis Pigmentosa

Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease

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Immunopharmacological actions of lumin. (II). Effect of lumin administration in NZB*NZW (B/W) F1 mice.

Cited by 4 publications

References 0 publications

Energy levels and crystal field parameters of Nd3+and Er3+in LiRP4O12single crystals

Energy levels and crystal field parameters of Nd3+and Er3+in LiRP4O12single crystals

The Effect of Cyanine Dye NK-4 on Photoreceptor Degeneration in a Rat Model of Early-Stage Retinitis Pigmentosa

Effects of NK-4 in a Transgenic Mouse Model of Alzheimer's Disease

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Energy levels and crystal field parameters of Nd³⁺and Er³⁺in LiRP₄O₁₂single crystals

Energy levels and crystal field parameters of Nd³⁺and Er³⁺in LiRP₄O₁₂single crystals