Immunopathology of toxic epidermal necrolysis. Keratinocytes, HLA-DR expression, Langerhans cells, and mononuclear cells: an immunopathologic study of five cases

The CD40/CD40 ligand system is expressed in the cutaneous lesions of erythema multiforme and Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum

“…This may depend on the different composition of the infiltrating lymphocytes in different phases. In agreement with previous studies, 28 CD4+ cells were more numerous than CD8+ cells in the lesional dermis of SJS/TEN. We confirmed that the epidermal exocytosis is focal and mainly composed by CD8+ T lymphocytes in EM, 24 while in SJS/TEN the lesional epidermis was strongly infiltrated by both CD4+ and CD8+ cells 8 .…”

A Role for Bioactivation and Covalent Binding within Epidermal Keratinocytes in Sulfonamide-Induced Cutaneous Drug Reactions

“…In one study, CD8+ dermal T cells from the lesional skin of a sulfonamide HS patient proliferated in response to SMX-modi®ed liver microsomes (Hertl et al, 1995), suggesting a drug-speci®c immune response. Moreover, epidermal Langerhans cell depletion, believed to be a hallmark of a cutaneous HS response, has been noted in similar lesional skin sections (Villada et al, 1992;Carr et al, 1994).…”

The severe complication of Stevens–Johnson syndrome induced by long-term clozapine treatment in a male schizophrenia patient: a case report

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