Immunopathology of angioimmunoblastic lymphadenopathy

Abstract

Eight patients with angioimmunoblastic lymphadenopathy have been studied by a variety of immunological and pathological techniques. They exhibited a spectrum of immunological reactivities that, in this small series, could be roughly correlated with survival. Those patients with relative B-cell predominance as shown by cell marker studies, histologically showed large numbers of plasma cells, and this pattern was associated in 3 of our patients with a survival of 3 years or more. T-cell predominance or both B- and T-cell depletion was associated histologically with large numbers of blast cells and eosinophils, but with few plasma cells. These patients responded poorly to therapy and had short survival times. One patient with B-cell predominance subsequently died of a histiocytic lymphoma. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10

Angioimmunoblastic lymphadenopathy

“…In one report, all seven patients studied were found to have lymph nodes with both cell-surface and intracytoplasmic polyclonal immunoglobulins [13]. Four patients have been reported to have lymph node cells with markers characteristic of T cells [77,101,104].…”

Mechanism of the induction of angiogenesis by human neoplastic lymphoid tissue: Studies on the chorioallantoic membrane (CAM) of the chick embryo

“…In-vivo studies have shown that macrophages play an active role in the proliferation of fibroblasts and endothelial cells (Leibovich and Ross, 1975) and also that vascular proliferation occurs at the same time as mononuclear cell infiltration (Polverini el al., 1977). These observations coupled with the histological results presented, suggest that the ability of tissue implants and tumour extracts to induce angiogenesis in the C A M is related to their ability to invoke a host mononuclear infiltrate at the implantation site.…”

“…Angiogenesis has also been described in mice following the intradermal injection of immuno-competent lymphocytes into histoincompatible recipients (Sidky and Auerbach, 1975). In man, angioimmunoblastic lymphadenopathy (AILD), a condition in which the lymphoid tissues show features of disturbed reactivity and in which malignant lymphoma may develop (Frizzera, Moran and Rappaport, 1974;Jones et al. 1978) is also characterised by the proliferation of small arborising blood vessels.…”

Αγγειοανοσοβλαστικη Λεμφαδενοπαθεια Απο Παθολογοανατομικη Κυριως Αποψη

“…Τά κυτταρι κά διηθήματα εντοπίζονται περισσότερο στά πυλαία διαστήματα καί είναι τίς περισσότε ρες φορές μή διαγνωστικά. Μπορούν νά παρατηρηθούν καί δευτερεύουσες εκφυλιστικές αλλοιώσεις στά ηπατικά κύτταρα" 5 " 48) .…”

“…Σπα νιότατα αναγνωρίζονται νεκρώσεις μέ τό γυμνό μάτι" 8 '. Παρά τή γενικευμένη KUÌ συχνά σημαντική σέ μέγεθος λεμφαδενοπάθεια, ογκοειδείς μάζες δέν παρατηρούνται στά σπλάγχνα'48 ', μπορεί όμως νά αναγνωρίζονται μέ τό γυμνό μάτι διάσπαρτα διηθήματα μέ τή μορφή όζίων σέ λεμφωματώδη εξαλλαγή'82 '. παρουσιάσθηκε ino τήν ομάδα του Lukes'67 ' νά μοιάζει με τήν υφή πού παρατηρείται στή νόσο του Hodgkin Ή μικροσκοπική υφή στίς τυπικές περιπτώσεις ΑΑΛ καί σπάνια χωρίς τήν εμπλοκή τροποποιητικών παραγόντων, π.χ.…”