Angioimmunoblastic lymphadenopathy

Azevedo, S. J.; Yunis, Adel A.

doi:10.1002/ajh.2830200314

Cited by 16 publications

(9 citation statements)

References 102 publications

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“…Although patients with IBL or IBL-T are known to be frequently complicated with various immunological ab normalities [9,10], variation of the complement system in these conditions has rarely been described [11]. In the present study, reduced levels of whole serum complement activity (CH50) were observed in 8 out of 9 patients at presentation, and the values subsequently rose to the nor mal range when remission was achieved.…”

Section: Discussionmentioning

confidence: 46%

“…While suppression of erythropoiesis in these conditions has only rarely been described [14][15][16][17][18], Azevcdo and Yunis reported that the reticulocyte count was reduced in 41 of 56 patients [10]. We observed a marked suppression of erythropoiesis resembling pure red cell aplasia (PRCA) in two patients with IBL-T.…”

Section: Discussionmentioning

confidence: 60%

“…Autoimmune hemolytic anemia (AIHA) frequently complicates IBL and IBL-T [9,10]. While suppression of erythropoiesis in these conditions has only rarely been described [14][15][16][17][18], Azevcdo and Yunis reported that the reticulocyte count was reduced in 41 of 56 patients [10].…”

Section: Discussionmentioning

confidence: 99%

“…These conditions are frequently accom panied by various hematological and immunological ab normalities [9,10]. However, the behavior of comple ment in these conditions has rarely been evaluated [ 11].…”

Section: Introductionmentioning

confidence: 99%

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Hypocomplementemia and Hematological Abnormalities in Immunoblastic Lymphadenopathy and Immunoblastic Lymphadenopathy-Like T Cell Lymphoma

Higuchi¹,

Mori²,

Niikura³

et al. 1996

Acta Haematol

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Serum complement levels and hematological data were evaluated in five patients with immunoblastic lymphadenopathy (IBL) and four with IBL-like T cell lymphoma (IBL-T). Anemia with Hb values below 10.0 g/dl was seen in four patients. A direct Coombs test was positive in five patients and the bone marrow of two of these showed features of pure red cell aplasia. Seven patients were thrombocytopenic with platelet counts below 100 × 10⁹/1. Six of the seven patients had splenomegaly. Platelet-associated IgG was elevated in all three thrombocytopenic patients examined. Whole complement activity (CH_5o) was reduced in eight patients (89%) at presentation and subsequently normalized in five who were treated either with prednisolone (two patients with IBL) or with multidrug combination chemotherapy (three with IBL-T). One patient achieved complete remission and four partial remission. Remission was accompanied by normalization of hematological abnormalities and elevation of complement activity to the normal range in all cases. These results suggested that complement-mediated mechanisms are responsible, at least in part, for some of the hematological abnormalities observed in IBL and IBL-T and that hypocomplementemia is a common abnormality with significance as a laboratory marker for the disease activity.

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Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypocomplementemia and Hematological Abnormalities in Immunoblastic Lymphadenopathy and Immunoblastic Lymphadenopathy-Like T Cell Lymphoma

Higuchi¹,

Mori²,

Niikura³

et al. 1996

Acta Haematol

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“…Alternatively, this evolution might be explained as a natural progression of the disease and this possibility cannot be excluded. A detailed long-term study of a larger number of patients is obviously needed as IBL/AILD patients generally have an aggressive course [26, 27]and it is possible that most of the patients die before such an evolution occurs.…”

Section: Discussionmentioning

confidence: 99%

Immunoblastic Lymphadenopathy-Like T Cell Lymphoma Evolving into a Massive Plasma Cell Proliferation with Biclonal Paraproteinemia

Higuchi

Tada²,

Mori³

et al. 1998

Acta Haematol

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We present a case of immunoblastic lymphadenopathy-like T cell lymphoma (IBL-T) who subsequently developed a massive proliferation of plasma cells. At diagnosis of IBL-T, the patient had polyclonal hypergammaglobulinemia and subsequently, while on chemotherapy, developed paraproteinemia with biclonal peaks and the IBL-T lesion was replaced with a massive proliferation of CD38-positive plasma cells. The evolution was not likely to be attributed to a new neoplastic proliferation of B cells. It appeared that two B cell clones possibly had a growth advantage among the polyclonal B cells due to a depletion of suppressor T cells or to a disturbance in the immune system.

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Colonic involvement in angioimmunoblastic lymphadenopathy resembling inflammatory bowel disease

Rosenstein

Rickert

Gutkin

et al. 1988

Cancer

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A woman 68 years of age had fever, malaise, diffuse lymphadenopathy, splenomegaly followed by abdominal pain, and diarrhea. A lymph node biopsy specimen showed nonspecific follicular hyperplasia. Symptoms were responsive initially to prednisone. Recurrent symptoms warranted colonic biopsy, which was consistent with Crohn's disease, and were responsive partially to prednisone and azulfidine. Because of progressive deterioration, a repeat lymph node biopsy was performed and showed the characteristic histologic feature of angioimmunoblastic lymphadenopathy (AILD). The evolution of the histopathologic features of the case is discussed, and gastrointestinal (GI) manifestations of AILD are reviewed. Although the GI tract is an unusual site for extra nodal AILD, colonic involvement can imitate the clinical and histologic features of inflammatory bowel disease.

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Angioimmunoblastic lymphadenopathy

Cited by 16 publications

References 102 publications

Hypocomplementemia and Hematological Abnormalities in Immunoblastic Lymphadenopathy and Immunoblastic Lymphadenopathy-Like T Cell Lymphoma

Hypocomplementemia and Hematological Abnormalities in Immunoblastic Lymphadenopathy and Immunoblastic Lymphadenopathy-Like T Cell Lymphoma

Immunoblastic Lymphadenopathy-Like T Cell Lymphoma Evolving into a Massive Plasma Cell Proliferation with Biclonal Paraproteinemia

Colonic involvement in angioimmunoblastic lymphadenopathy resembling inflammatory bowel disease

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