Immunomodulatory properties of silver-containing nanocomposite on the basis of polyvinyltriazole

Прозорова, Г. Ф.; Pozdnyakov, A. S.; ́yanov, A. I. Emel; Ермакова, Т. Г.; Дубровина, В. И.

doi:10.1007/s11172-015-1028-x

Cited by 17 publications

(6 citation statements)

References 8 publications

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“…Among the important properties of this polymer are pharmacological activity, nontoxicity, and resistance to aggressive media. Silver nanoparticles incorporated into the PVT matrix exhibit high antibacterial, immunomodulatory, and cytotoxic activity, enhance body defenses, and exert a protective effect against the Yersinia pestis bacteria and anthrax [ 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

One-Pot Preparation of Metal–Polymer Nanocomposites in Irradiated Aqueous Solutions of 1-Vinyl-1,2,4-triazole and Silver Ions

et al. 2021

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Metal–polymer nanocomposite polyvinyltriazole–silver nanoparticles were obtained using one-pot synthesis in irradiated aqueous solutions of 1-vinyl-1,2,4-triazole (VT) and silver ions. Gel permeation chromatography data show that upon radiation initiation, the molecular weight of poly(1-vinyl-1,2,4-triazole) increases with increasing monomer concentration. To study the kinetics of polymerization and the features of the radiation–chemical formation of nanoparticles, UV-Vis spectroscopy was used. TEM images show a relatively small average size of the forming nanoparticles (2–3 nm) and a narrow size distribution, which shows the effective stabilization of nanoparticles by triazole substituents at a molar ratio of VT and silver ions of 25/1. The addition of ethyl alcohol was used to increase the efficiency of synthesis and suppress the crosslinking of macromolecules in solution. The results of the work show that aqueous–alcoholic solutions of 1 wt.% VT can be used to obtain soluble nanocomposite materials. 10 wt.% monomer solutions have prospects for use in the preparation of polymer gels filled with nanoparticles.

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Section: Introductionmentioning

confidence: 99%

One-Pot Preparation of Metal–Polymer Nanocomposites in Irradiated Aqueous Solutions of 1-Vinyl-1,2,4-triazole and Silver Ions

et al. 2021

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“…This also provides evidence that protective properties of the body are improved. The nanocomposite stimulates generation of oxygen effective forms by phagocytes, increases the production of nitrogen oxide metabolites by a factor of 2.5 (relative to the standard), and facilitates reduction in the amount of highly toxic oxygen radicals in a cell owing to activation of the catalytic capacity of superoxide dismutase [ 90 ]. The nanocomposite demonstrates protective properties against infection caused by the virulent strain Y. Pestis I-2638 for plague-susceptible white mice.…”

Section: Immunomodulatory Properties Of Poly(1-vinyl-124-triazole) ...mentioning

confidence: 99%

“…Subcutaneous administration of the nanocomposite 60 min before infection at a dose of 10 and 100 mg/kg facilitates the survival of 30 and 50% of infected animals, respectively. The single administration of the nanocomposite at a dose of 10 mg/kg (subcutaneously) 8 days before infection protects 89% animals against dearth [ 90 ].…”

Section: Immunomodulatory Properties Of Poly(1-vinyl-124-triazole) ...mentioning

confidence: 99%

Synthesis, Properties, and Biological Activity of Poly(1-vinyl-1,2,4-triazole) and Silver Nanocomposites Based on It

Прозорова

Pozdnyakov

2022

Polym. Sci. Ser. C

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The review summarizes the data on the synthesis, physicochemical properties, and biological activity of poly(1-vinyl-1,2,4-triazole) and its nanocomposites with silver nanoparticles. The results of studying the antibacterial and antitumor activity of the polymers and nanocomposites and their immunomodulatory ability, toxicity, and interaction with body cells, as well as the prospects for their use in the development of medical materials, are presented.

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“…The specific properties of metals in an ultradispersed state open up wide opportunities for the creation of new effective catalysts, sensor systems, and drugs with high biological activity for use in medicine, ecology, and agriculture [ 1 , 2 , 3 , 4 , 5 , 6 ]. Metal nanoparticles are the objects of active study, due to their increased reactivity, interesting biological properties, small size, and ability to penetrate into the cells of the body [ 7 , 8 , 9 , 10 , 11 , 12 ]. Currently, nano-sized structures and copper nanoparticles in particular find ever increasing application in various fields.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Stable Nanocomposites Containing Copper Nanoparticles Incorporated in Poly-N-vinylimidazole

et al. 2021

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New stable nanocomposites with copper nanoparticles (CuNPs) in a polymer matrix have been synthesized by green chemistry. Non-toxic poly-N-vinylimidazole was used as a stabilizing polymer matrix and ascorbic acid was used as a reducing agent. The polymer CuNPs nanocomposites were characterized by Fourier transform infrared (FTIR) spectroscopy, ultraviolet–visible (UV) spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), atomic absorption spectroscopy (AAS), and thermogravimetric analysis (TGA). It was shown, using the dynamic light scattering (DLS) method, that the hydrodynamic diameters of nanocomposites depend on the CuNPs content and are in an associated state in an aqueous medium. The copper content in nanocomposites ranges from 1.8 to 12.3% wt. The obtained polymer nanocomposites consist of isolated copper nanoparticles with a diameter of 2 to 20 nm with a spherical shape.

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Immunomodulatory properties of silver-containing nanocomposite on the basis of polyvinyltriazole

Cited by 17 publications

References 8 publications

One-Pot Preparation of Metal–Polymer Nanocomposites in Irradiated Aqueous Solutions of 1-Vinyl-1,2,4-triazole and Silver Ions

One-Pot Preparation of Metal–Polymer Nanocomposites in Irradiated Aqueous Solutions of 1-Vinyl-1,2,4-triazole and Silver Ions

Synthesis, Properties, and Biological Activity of Poly(1-vinyl-1,2,4-triazole) and Silver Nanocomposites Based on It

Green Synthesis of Stable Nanocomposites Containing Copper Nanoparticles Incorporated in Poly-N-vinylimidazole

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