Immunomodulatory nanosystems for treating inflammatory diseases

Ahamad, Nadim; Kar, Abhinanda; Mehta, Sourabh; Dewani, Mahima; Ravichandran, Vasanthan; Bhardwaj, Prateek; Sharma, Shivam; Banerjee, Rinti

doi:10.1016/j.biomaterials.2021.120875

Cited by 41 publications

(33 citation statements)

References 226 publications

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“…In addition, decorating gold nanoparticles with chitosan which resulted in the positive charge of G1 resulted in the attraction of inflammatory cytokines from the inflamed microenvironment, our findings are in agreement with those obtained by Ahamad et al. ( 2021 ). As for G2, it was retained in the skin due to several factors; the conjugation with L nanoparticles which have a higher tendency to deposit gold nanoparticles in the skin because of the chitosan corona, the high viscosity of G2 due to the presence of lecithin; in addition to, its lipidic nature and small PS, accordingly G2 was evidently retained in the skin upon imaging.…”

Section: Resultssupporting

confidence: 93%

Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling

et al. 2022

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Gold nanoparticles are a promising drug delivery system for treatment of inflammatory skin conditions, including psoriasis, due to their small size and anti-inflammatory properties. The aim of this study was to conjugate gold nanoparticles with anti-psoriatic formulations that previously showed successful results in the treatment of psoriasis (tacrolimus-loaded chitosan nanoparticles and lecithin–chitosan nanoparticles) by virtue of their surface charges, then examine whether the hybridization with gold nanoparticles would enhance the anti-psoriatic efficacy in vivo . Successful formation of gold nanoparticles was examined by elemental mapping and selected area electron diffraction (SAED). Hybrid conjugates were examined in terms of particle size and zeta potential by dynamic light scattering (DLS). Morphological features were captured by transmission electron microscope (TEM) and X-ray diffraction (XRD) analysis was conducted, as well. All characterization was conducted for the conjugated nanoparticles and compared with their bare counterparts. The in vivo results on imiquimod (IMQ)-induced mouse model showed promising anti-psoriatic effects upon application of gold conjugated tacrolimus-loaded lecithin–chitosan hybrid nanoparticles with a significant difference from the bare hybrid nanoparticles in some of the inflammatory markers. The anti-inflammatory effect of the gold conjugate was also evident by a lower spleen to body weight ratio and a better histopathological skin condition compared to other tested formulations.

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Section: Resultssupporting

confidence: 93%

Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling

et al. 2022

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“…At present, the basic research direction for the treatment of macrophage polarization and PD includes identifying ways to control the polarization of macrophages. Since most treatments for inflammatory diseases, including periodontitis, provide only short-term relief, the new concept of immunomodulatory nanosystems (IMNs) has the potential to change this situation ( 167 ). Macrophage polarization is one of the ways in which IMNs play an immunomulatory role.…”

Section: Immunoregulatory Treatment Of Periodontitis Associated With Macrophage Polarizationmentioning

confidence: 99%

Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling

et al. 2021

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Periodontitis (PD) is a common chronic infectious disease. The local inflammatory response in the host may cause the destruction of supporting periodontal tissue. Macrophages play a variety of roles in PD, including regulatory and phagocytosis. Moreover, under the induction of different factors, macrophages polarize and form different functional phenotypes. Among them, M1-type macrophages with proinflammatory functions and M2-type macrophages with anti-inflammatory functions are the most representative, and both of them can regulate the tendency of the immune system to exert proinflammatory or anti-inflammatory functions. M1 and M2 macrophages are involved in the destructive and reparative stages of PD. Due to the complex microenvironment of PD, the dynamic development of PD, and various local mediators, increasing attention has been given to the study of macrophage polarization in PD. This review summarizes the role of macrophage polarization in the development of PD and its research progress.

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“…M1 type cells attract many other cell types at the inflamed site via pro-inflammatory cytokines and chemokines and ultimately worsen the situation in inflamed tissue [ 59 ], while M2 cells acts the opposite, with anti-inflammatory cytokines released and inflammatory status will be relieved. Based on such theory, a number of nanoparticle formulas have been developed to modulate macrophage polarization more towards M2 type, while restricting M1 macrophage population at the same time [ 60 , 61 ]. Strategies include cytokines delivery, metal nanoparticles, plasmid DNA/microRNA delivery etc.…”

Section: The Interaction Between Nps and The Immune Systemmentioning

confidence: 99%

“…Other mechanisms like adjusting neural-immune cells cross-talk, preventing hypoxia relevant apoptosis and modulating interaction between immune effector cells and non-immune cells have also been explored [ 60 , 151 ], but their potential in treating inflammatory diseases still need to be further confirmed by in vivo studies.…”

Section: The Interaction Between Nps and The Immune Systemmentioning

confidence: 99%

The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

Liu

Pang

et al. 2022

J Nanobiotechnol

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Nanoparticle (NP) is an emerging tool applied in the biomedical field. With combination of different materials and adjustment of their physical and chemical properties, nanoparticles can have diverse effects on the organism and may change the treating paradigm of multiple diseases in the future. More and more results show that nanoparticles can function as immunomodulators and some formulas have been approved for the treatment of inflammation-related diseases. However, our current understanding of the mechanisms that nanoparticles can influence immune responses is still limited, and systemic clinical trials are necessary for the evaluation of their security and long-term effects. This review provides an overview of the recent advances in nanoparticles that can interact with different cellular and molecular components of the immune system and their application in the management of inflammatory diseases, which are caused by abnormal immune reactions. This article focuses on the mechanisms of interaction between nanoparticles and the immune system and tries to provide a reference for the future design of nanotechnology for the treatment of inflammatory diseases. Graphical Abstract

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Immunomodulatory nanosystems for treating inflammatory diseases

Cited by 41 publications

References 226 publications

Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling

Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in vivo modeling

Polarized Macrophages in Periodontitis: Characteristics, Function, and Molecular Signaling

The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

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