The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

Liu, Jin; Liu, Zeyang; Pang, Yan; Zhou, Huifang

doi:10.1186/s12951-022-01343-7

Cited by 53 publications

(43 citation statements)

References 161 publications

(217 reference statements)

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“…[24,25] Furthermore, as a family member of professional phagocytes, they move around to initiate the clearance of foreign nano/micro materials. [26,27] Therefore, the migration properties of macrophages play crucial roles during inflammatory responses [28] and phagocytosis. [29] Different types of nano/microparticles have been used for drug delivery and macrophages have been reported to be the dominant cell type that interacts with those particles.…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Observation of Interactions between Macrophages and Inorganic Particles with Different Densities

Zhang

Tang

Xie

et al. 2022

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Many different types of inorganic materials are processed into nano/microparticles for medical utilization. The impact of selected key characteristics of these particles, including size, shape, and surface chemistries, on biological systems, is frequently studied in clinical contexts. However, one of the most important basic characteristics of these particles, their density, is yet to be investigated. When the particles are designed for drug delivery, highly mobile macrophages are the major participants in cellular levels that process them in vivo. As such, it is essential to understand the impact of particles’ densities on the mobility of macrophages. Here, inorganic particles with different densities are applied, and their interactions with macrophages studied. A set of these particles are incubated with the macrophages and the outcomes are explored by optical microscopy. This microscopic view provides the understanding of the mechanistic interactions between particles of different densities and macrophages to conclude that the particles’ density can affect the migratory behaviors of macrophages: the higher the density of particles engulfed inside the macrophages, the less mobile the macrophages become. This work is a strong reminder that the density of particles cannot be neglected when they are designed to be utilized in biological applications.

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Section: Introductionmentioning

confidence: 99%

Mechanistic Observation of Interactions between Macrophages and Inorganic Particles with Different Densities

Zhang

Tang

Xie

et al. 2022

Small

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“…It is necessary to examine the appropriate conditions for the addition of nanospheres to immune cells, such as monocytes and macrophages, because the nanospheres addition may induce an immune response in these cells. 58,59 MB targeting the CD204 gene whose expression is upregulated in the THP-1 cells differentiation into macrophages, were encapsulated in cGNS and added to cells. In Figure 5, the fluorescence intensity of CD204 MB significantly increased when compared with that of MB targeting GAPDH of a house keeping gene at 36 h. This indicates that the fluorescence of CD204 MB increased in response to the change in CD204 gene expression.…”

Section: ■ Discussionmentioning

confidence: 99%

“…The nanospheres showed no effect on the cell differentiation in the culture condition used. It is necessary to examine the appropriate conditions for the addition of nanospheres to immune cells, such as monocytes and macrophages, because the nanospheres addition may induce an immune response in these cells. , …”

Section: Discussionmentioning

confidence: 99%

Live Imaging of Monocyte/Macrophage Differentiation with Cationized Gelatin Nanospheres Incorporating a Molecular Beacon

Washisaka

Tabata

2023

ACS Biomater. Sci. Eng.

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As one imaging method to evaluate monocyte–macrophage differentiation, cationized gelatin nanospheres incorporating a molecular beacon (MB) (cGNSMB) were designed. Cationized gelatin nanospheres (cGNS) of different apparent sizes were prepared by the conventional coacervation method, and then the MB of CD204 was incorporated into cGNS to prepare cGNSMB. When three types of cGNSMB were cultured with human monocytoma (THP-1) cells, the cGNSMB with a 110 nm diameter showed the highest MB delivery efficiency. In addition, no influence on the monocyte–macrophage differentiation was observed in terms of CD204 gene expression and cell viability. After incubation with cGNS incorporating CD204 MB (cGNSCD204), THP-1 cells were stimulated by phorbol 12-myristate 13-acetate (PMA) for monocyte differentiation into macrophages. The fluorescence intensity of macrophages increased with the incubation time. In contrast, the fluorescence intensity of macrophages incubated with MB alone was not changed. On the other hand, there was no change in the fluorescence intensity of original THP-1 cells cultured with cGNSCD204. It is concluded that the cGNSCD204 are promising to trace the differentiation of THP-1 cells into macrophages in their live condition.

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“…Moreover, targeting moieties can be functionalized on the surfaces of NPs to promote their active accumulation in targeted tissues to realize targeted drug delivery and therapy, which can reduce offsite toxicity and side-effects. 45 46 47 48 49 50 Various types of NPs such as liposomes, polymeric NPs, dendrimers, lipid NPs, silica NPs, quantum dots, and metallic NPs have been investigated for treating anti-inflammatory diseases. This is because these NPs can be designed for drug delivery to different biological destinations, which alleviates the challenges of systemic toxicity and rapid renal clearance associated with conventional treatments.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in ROS-Scavenging Metallic Nanozymes for Anti-Inflammatory Diseases: A Review

Mohapatra

Park

2023

Chonnam Med J

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Oxidative stress and dysregulated inflammatory responses are the hallmarks of inflammatory disorders, which are key contributors to high mortality rates and impose a substantial economic burden on society. Reactive oxygen species (ROS) are vital signaling molecules that promote the development of inflammatory disorders. The existing mainstream therapeutic approaches, including steroid and non-steroidal anti-inflammatory drugs, and proinflammatory cytokine inhibitors with anti-leucocyte inhibitors, are not efficient at curing the adverse effects of severe inflammation. Moreover, they have serious side effects. Metallic nanozymes (MNZs) mimic the endogenous enzymatic process and are promising candidates for the treatment of ROS-associated inflammatory disorders. Owing to the existing level of development of these metallic nanozymes, they are efficient at scavenging excess ROS and can resolve the drawbacks of traditional therapies. This review summarizes the context of ROS during inflammation and provides an overview of recent advances in metallic nanozymes as therapeutic agents. Furthermore, the challenges associated with MNZs and an outline for future to promote the clinical translation of MNZs are discussed. Our review of this expanding multidisciplinary field will benefit the current research and clinical application of metallic-nanozyme-based ROS scavenging in inflammatory disease treatment.

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The interaction between nanoparticles and immune system: application in the treatment of inflammatory diseases

Cited by 53 publications

References 161 publications

Mechanistic Observation of Interactions between Macrophages and Inorganic Particles with Different Densities

Mechanistic Observation of Interactions between Macrophages and Inorganic Particles with Different Densities

Live Imaging of Monocyte/Macrophage Differentiation with Cationized Gelatin Nanospheres Incorporating a Molecular Beacon

Recent Advances in ROS-Scavenging Metallic Nanozymes for Anti-Inflammatory Diseases: A Review

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