Immunomodulatory Methods

Kassab, Cynthia; Kerrigan, Brittany Parker; Caruso, Hillary G.; Enazy, Sanaalarab Al; Heimberger, Amy B.

doi:10.1016/b978-0-12-813997-4.00015-3

Cited by 3 publications

(1 citation statement)

References 280 publications

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“…Virus-specific TH-17 compartments might co definite last cytokines and can precise CCR4 or CXCR3 (15). Cytokines dismiss each be pro-inflammatory otherwise antiinflammatory and categorized agreeing to their cell of basis or their machines of achievement (16). Proinflammatory cytokines be situated essential for up-regulation of soreness and made essentially by way of initiated macrophages (17).…”

Section: Table (1): Il-17 Concentration In Serum Of Studied Groupsmentioning

confidence: 99%

Cytomegalovirus in Pregnant Woman

Abdul Amir

2024

clin. med. & helt. res. jour.

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Fourty patients were diagnosed with Cytomegalovirus in pregnant with fever, weariness, and lymphadenitis. ELISA was recycled to check CMV IgG antibodies. A entire of 40 patients sera infested by means of lymphadenitis plus 40 regulator sera joined hip this learning be present calculated in place of IL-17 and IL-1β levels in their blood. The results point to significant transformation amongst patients and control for IL-17, while no difference between them at IL-1β.

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Section: Table (1): Il-17 Concentration In Serum Of Studied Groupsmentioning

confidence: 99%

Cytomegalovirus in Pregnant Woman

Abdul Amir

2024

clin. med. & helt. res. jour.

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Mapping the intellectual structure of the coronavirus field (2000–2020): a co-word analysis

et al. 2021

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Over the two last decades, coronaviruses have affected human life in different ways, especially in terms of health and economy. Due to the profound effects of novel coronaviruses, growing tides of research are emerging in various research fields. This paper employs a co-word analysis approach to map the intellectual structure of the coronavirus literature for a better understanding of how coronavirus research and the disease itself have developed during the target timeframe. A strategic diagram has been drawn to depict the coronavirus domain’s structure and development. A detailed picture of coronavirus literature has been extracted from a huge number of papers to provide a quick overview of the coronavirus literature. The main themes of past coronavirus-related publications are (a) “Antibody-Virus Interactions,” (b) “Emerging Infectious Diseases,” (c) “Protein Structure-based Drug Design and Antiviral Drug Discovery,” (d) “Coronavirus Detection Methods,” (e) “Viral Pathogenesis and Immunity,” and (f) “Animal Coronaviruses.” The emerging infectious diseases are mostly related to fatal diseases (such as Middle East respiratory syndrome, severe acute respiratory syndrome, and COVID-19) and animal coronaviruses (including porcine, turkey, feline, canine, equine, and bovine coronaviruses and infectious bronchitis virus), which are capable of placing animal-dependent industries such as the swine and poultry industries under strong economic pressure. Although considerable research into coronavirus has been done, this unique field has not yet matured sufficiently. Therefore, “Antibody-virus Interactions,” “Emerging Infectious Diseases,” and “Coronavirus Detection Methods” hold interesting, promising research gaps to be both explored and filled in the future.

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P38 MAPK/AKT signalling is involved in IL-33-mediated anti-apoptosis in childhood acute lymphoblastic leukaemia blast cells

et al. 2021

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Background Acute lymphoblastic leukaemia (ALL) is often characterized by broad clinical and biological heterogeneity, as well as recurrent genetic aberrations. Despite remarkable improvements in the treatment outcome in paediatric ALL over the past several decades, it remains a leading cause of morbidity and mortality among children. Cytokines have been extensively studied in haematologic diseases; however, the mechanisms by which cytokines contribute to ALL pathogenesis remain poorly understood. Methods IL-33 levels were measured by enzyme-linked immunosorbent assay (ELISA). IL1RL1 expression on ALL cell surface was accessed by flow cytometry. Expression of phosphorylated p38 MAPK, p38, pAKT, AKT and GAPDH were quantified by western blot. Cell survival signals were evaluated by apoptosis using flow cytometry. Results BM samples from ALL patients at diagnosis upregulated their cell surface expression of IL1RL1, and a higher interleukin (IL)-33 level in the serum was observed as compared to the healthy individuals. Moreover, exogenous IL-33 treatment significantly inhibited apoptosis by activating p38 mitogen-activated protein kinase (MAPK) and AKT pathway, while the inhibitor for p38 MAPK, SB203580, counteracted IL-33-induced anti-apoptosis via inactivation of p38 MAPK and AKT. Furthermore, IL-33 negatively regulates cyclin B1 protein level while increasing the expression of CDK1, with SB203580 inhibiting the effect. Conclusion Our study reveals an important role for IL-33/IL1RL1 axis in supporting ALL which may represent a novel treatment for paediatric patients. KEY MESSAGES Both IL-33 and IL1RL1 levels are upregulated in primary ALL samples. IL-33 increased both p38 MAPK and AKT activation in ALL. IL-33 promotes survival and cell cycle progression of ALL cells via activating p38 MAPK.

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Immunomodulatory Methods

Cited by 3 publications

References 280 publications

Cytomegalovirus in Pregnant Woman

Cytomegalovirus in Pregnant Woman

Mapping the intellectual structure of the coronavirus field (2000–2020): a co-word analysis

P38 MAPK/AKT signalling is involved in IL-33-mediated anti-apoptosis in childhood acute lymphoblastic leukaemia blast cells

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