Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders

Čaprnda, Martin; Kubatka, Peter; Gazdíková, Katarína; Gašparová, Iveta; Valentová, Vanda; Stollárová, Nadežda; Rocca, Giampiero La; Kobyliak, Nazarii; Dragašek, Jozef; Mozoş, Ioana; Prosecký, Robert; Siniscalco, Dario; Büsselberg, Dietrich; Rodrigo, Luís; Kružliak, Peter

doi:10.1016/j.biopha.2017.04.034

Cited by 26 publications

(18 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Stem cell transplantation is actively studied as a therapeutic option for autoimmune and degenerative disorders (e.g., HSCs for type 1 diabetes and NSCs for Alzheimer's disease) (19,171). However, their application is challenging, as in vitro, the mutation accumulation rate in adult stem cells is nearly 40-fold higher than in vivo, which is likely caused by oxidative stress imposed by culturing conditions (90,144).…”

Section: Resultsmentioning

confidence: 99%

Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective

Ludikhuize

Colman

2021

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Significance: Stem cell activation and differentiation occur along changes in cellular metabolism. Metabolic transitions translate into changes in redox balance, cell signaling, and epigenetics, thereby regulating these processes. Metabolic transitions are key regulators of cell fate and exemplify the moonlighting nature of many metabolic enzymes and their associated metabolites. Recent Advances: Forkhead box O transcription factors (FOXOs) are bona fide regulators of cellular homeostasis. FOXOs are multitasking proteins able to regulate cell cycle, cellular metabolism, and redox state. Recent and ongoing research poses FOXOs as key factors in stem cell maintenance and differentiation in several tissues. Critical Issues: The multitasking nature of FOXOs and their tissue-specific expression patterns hinders to disclose a possible conserved mechanism of regulation of stem cell maintenance and differentiation. Moreover, cellular metabolism, cell signaling, and epigenetics establish complex regulatory interactions, which challenge the establishment of the causal/temporal nature of metabolic changes and stem cell activation and differentiation. Future Directions: The development of single-cell technologies and in vitro models able to reproduce the dynamics of stem cell differentiation are actively contributing to define the role of metabolism in this process. This knowledge is key to understanding and designing therapies for those pathologies where the balance between proliferation and differentiation is lost. Importantly, metabolic interventions could be applied to optimize stem cell cultures meant for therapeutical applications, such as transplantations, to treat autoimmune and degenerative disorders. Antioxid. Redox Signal. 00, 000-000.

show abstract

Section: Resultsmentioning

confidence: 99%

Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective

Ludikhuize

Colman

2021

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

show abstract

“…It is known that these cells have a capacity for expansion and differentiation, have a chemotactic effect, and are capable of performing local immunomodulation (Yamada et al, 2013;De Wolf et al, 2017;Mohammadi Ayenehdeh et al, 2017). More recently, it has become increasingly clear that cells exert a favourable effect by secreting cytokines and other paracrine factors, growth factors, antifibrotic factors, and angiogenic mediators, which involves and recruits receptor cells during tissue repair (Da Silva Meirelles et al, 2009;Tolar et al, 2010;Caprnda et al, 2017). According to Smith and Mcllwraith (2014), the current challenges in MSC transplantation includes modulating the beneficial and harmful effects of the inflammation and the local cellular response secondary to the application of stem cells.…”

Section: Introductionmentioning

confidence: 99%

Allogeneic mesenchymal stem cell transplantation in healthy equine superficial digital flexor tendon: A study of the local inflammatory response

Brandão

Alvarenga

Pfeifer

et al. 2018

Research in Veterinary Science

View full text Add to dashboard Cite

The superficial digital flexor tendon (SDFT) is a structure frequently affected by injuries in high-performance athletic horses, and there are limited therapeutic options. Regenerative medicine has evolved significantly in treating different illnesses. However, understanding the cellular behaviour during mesenchymal stem cell (MSC) transplantation in healthy tissues is not fully known yet. To address the inflammatory response induced by allogeneic MSC transplantation, this study evaluated the local inflammatory response after the application of allogeneic adipose tissue-derived mesenchymal stem cells (AT-MSCs) in the equine tendon compared to an autologous transplant and the control group. Eighteen thoracic limbs (TL) in nine animals were divided into three groups and subjected to the application of AT-MSCs in the healthy tendon. In the allogeneic group (Gallog), the animals received an allogeneic AT-MSC application in the TL. The autologous group (Gauto) received an application of autologous cells in the TL, and in the control group (Gcont), phosphate-buffered saline (PBS) was applied. There were no significant differences among the evaluated groups in the physical, morphological, thermography, and ultrasonography analyses. A higher number of CD3-positive lymphocytes was observed in the Gauto group compared to the control (P < 0.05). Additionally, we did not observe different expressions of CD172 and microvascular density among the groups. The allogeneic transplantation of AT-MSCs did not result in an adverse or inflammatory reaction that compromised the use of these cells in this experiment. Their behaviour was similar to that of autologous transplantation.

show abstract

“…Stem cells are able to strongly inhibit CD8 + and CD4 + T lymphocytes and NK cell overactivation and proliferation by inhibiting proinflammatory tumor necrosis factor alpha and interferon gamma molecules and increasing anti-inflammatory IL-10 levels. 31 This fact is confirmed by an animal model of autism, in which stem cells, once transplanted, were able to increase anti-inflammatory cytokine production (detailed in Stem cells and autism: animal models section). The ability to modulate the immune system by stem cells is mediated via soluble factors released by stem cells under local chemical environment signaling.…”

Section: Stem Cells For Neurologic Diseasesmentioning

confidence: 86%

Stem cell therapy in autism: recent insights

Siniscalco¹,

Suresh

Semprún-Hernández

et al. 2018

SCCAA

Self Cite

View full text Add to dashboard Cite

Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities. ASDs comprise heterogeneous and complex neurodevelopmental pathologies with well-defined inflammatory conditions and immune system dysfunction. Due to neurobiologic changes underlying ASD development, cell-based therapies have been proposed and applied to ASDs. Indeed, stem cells show specific immunologic properties, which make them promising candidates in ASD treatment. This comprehensive up-to-date review focuses on ASD cellular/molecular abnormalities, potentially useful stem cell types, animal models, and current clinical trials on the use of stem cells in treating autism. Limitations are also discussed.

show abstract

Immunomodulatory effects of stem cells: Therapeutic option for neurodegenerative disorders

Cited by 26 publications

References 114 publications

Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective

Metabolic Regulation of Stem Cells and Differentiation: A Forkhead Box O Transcription Factor Perspective

Allogeneic mesenchymal stem cell transplantation in healthy equine superficial digital flexor tendon: A study of the local inflammatory response

Stem cell therapy in autism: recent insights

Contact Info

Product

Resources

About