2010
DOI: 10.1128/iai.00111-10
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Abstract: Glucuronoxylomannan (GXM), the major capsular component in the Cryptococcus complex, interacts with the immune system in multiple ways, which include the activation of Toll-like receptors (TLRs) and the modulation of nitric oxide (NO) production by phagocytes. In this study, we analyzed several structural parameters of GXM samples from Cryptococcus neoformans (serotypes A and D) and Cryptococcus gattii (serotypes B and C) and correlated them with the production of NO by phagocytes and the activation of TLRs. G… Show more

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Cited by 67 publications
(59 citation statements)
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“…All polysaccharide fractions tested in the present work had the same concentration, thus it is unlikely that this observation would simply reflect a higher number of chitinbinding sites. GXM tridimensional structure is highly complex (13), and recent observations indicate that polysaccharide samples of different molecular masses manifest functional differences (22). Thus, we believe that the superior efficacy of high molecular mass fractions to interact with chitin may reflect still unknown structural properties that would foster stable interactions between both polysaccharides.…”
Section: Discussionmentioning
confidence: 91%
“…All polysaccharide fractions tested in the present work had the same concentration, thus it is unlikely that this observation would simply reflect a higher number of chitinbinding sites. GXM tridimensional structure is highly complex (13), and recent observations indicate that polysaccharide samples of different molecular masses manifest functional differences (22). Thus, we believe that the superior efficacy of high molecular mass fractions to interact with chitin may reflect still unknown structural properties that would foster stable interactions between both polysaccharides.…”
Section: Discussionmentioning
confidence: 91%
“…The ζ potential of vesicles samples suspended in 10 mM dextrose were calculated in a ζ potential analyzer (ZetaPlus; Brookhaven Instruments Corp.) (44,45).…”
Section: Measurement Of Vesicle Size By Qelsmentioning
confidence: 99%
“…In C. albicans glucuronoxylomannan (GXM), mannan, β1,3-and β1,6-glucan and phospholipomannan (PLM) of cell wall were identified as PAMPs. Also, GXM of C. neoformans, C. gattii and A. fumigatus were recognized as PAMPs (Fonseca et al 2010, Brown 2011, Burgeois and Kuchler 2012. Additionally, some fungal proteins can be sensed e.g.…”
Section: The First Element Of Defense -The Recognition Of Pathogen: Pmentioning
confidence: 99%
“…DNA and RNA of Candida spp. and A. fumigatus alike DNA of C. neoformans and Malassezia furfur (Fonseca et al 2010, Brown 2011, Burgeois and Kuchler 2012. However, nucleic acids are exposed for recognition only after the fungus is destroyed or phagocytosed.…”
Section: The First Element Of Defense -The Recognition Of Pathogen: Pmentioning
confidence: 99%