Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice

Zhang, Jian; Gao, Siwei; Li, He; Cao, Mengdi; Li, Wenhui; Liu, Xinqi

doi:10.1002/fsn3.2594

Cited by 26 publications

(30 citation statements)

References 82 publications

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“…IgM and IgG, secreted by B cells, are two key effector molecules in the humoral immune response. IgM exhibits a strong anti-infectious effect, while IgG participates in the phagocytosis of monocytes ( Zhang et al, 2021 ). T lymphocytes are important immune cells involved in the regulation of cellular immunity.…”

Section: Discussionmentioning

confidence: 99%

Immunoregulatory activity of a low-molecular-weight heteropolysaccharide from Ganoderma leucocontextum fruiting bodies in vitro and in vivo

Guan

Zeng

et al. 2022

Food Chemistry: X

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Section: Discussionmentioning

confidence: 99%

Immunoregulatory activity of a low-molecular-weight heteropolysaccharide from Ganoderma leucocontextum fruiting bodies in vitro and in vivo

Guan

Zeng

et al. 2022

Food Chemistry: X

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“…The absorbance of the subsequent compounds was measured at 440 nm (proline [Pro]) and 570 nm (all other amino acids). The molecular weight distribution of SePPs was determined following a previously reported method ( 13 ). Standard molecular weight samples of aprotinin (6500 Da), bacitracin (1422 Da), Gly-Gly-Tyr-Arg (451 Da), and reduced GSH (307 Da) were passed through a 0.22 μm filter and deposited in a Superdex 200 10/300 GL column.…”

Section: Methodsmentioning

confidence: 99%

“…According to Liu et al, selenium biofortified soy peptides could reduce CCl 4 -induced liver fibrosis by increasing GSH-Px activity and GSH content, improving hepatocyte survival, inhibiting hepatic stellate cell activation, and improving antioxidant capacity ( 12 ). Zhang et al observed that SePPs could regulate immunoglobulin (Ig)M, IgG, and IgA secretion, significantly increase splenic interleukin 2 (IL-2), interferon-gamma (IFN-γ), nitric oxide (NO), and cyclic guanosine monophosphate (cGMP) production, and IL-2, IFN-γ, and inducible NO synthase (iNOs) mRNA expression, as well as enhance host-specific and non-specific immunity via a cyclophosphamide-induced immunosuppression mice model ( 13 ). The beneficial effects of selenium-enriched peptides on health were confirmed previously, whereas, the protective mechanism of selenium-enriched peptides against heatstroke-induced liver injury is still unclear.…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Comparison of Different Selenium Supplements: Mitigation of Heat Stress and Exercise Fatigue-Induced Liver Injury

Chen

Zhang

et al. 2022

Front. Nutr.

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This study aimed to compare the protective effects of different selenium supplements against heat stress and exercise fatigue-induced liver injury and to investigate the potential mechanisms of action. Selenium-enriched soybean protein (SePro), selenium-enriched soybean peptides (SePPs), and selenomethionine (SeMet) are organic selenium supplements in which selenium replaces the sulfur in their sulfur-containing amino acids. Common peptides (PPs) are obtained by enzymatic hydrolysis of soybean protein which was extracted from common soybean. The SePPs with higher hydrolysis degree and selenium retention were isolated via alkaline solubilization and acid precipitation and the enzymatic hydrolysis of alkaline protease, neutral protease, and papain. The results showed that SePPs could significantly increase the antioxidant levels in rats, inhibit lipid peroxidation, and reduce liver enzyme levels in rat serum, while the histological findings indicated that the inflammatory cell infiltration in the liver tissue was reduced, and new cells appeared after treatment with SePPs. Moreover, SePPs could increase glutathione (GSH) and GSH peroxidase (GSH-Px) in the liver, as well as protect the liver by regulating the NF-κB/IκB pathway, prevent interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α) release in the liver. The SePPs displayed higher antioxidant and anti-inflammatory activity in vivo than SePro, SeMet, Sodium selenite (Na2SeO3), and PPs. Therefore, SePPs could be used as a priority selenium resource to develop heatstroke prevention products or nutritional supplements.

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“…Similarly to Met, a particular therapeutic interest has been attributed to selenium, an essential micronutrient, for its pleiotropic and immunomodulatory effects [11,12], as well as for its potent role in inhibition of expression of LPS induced proinflammatory cytokines [13]. It also enhances immunity and the function of cytotoxic effector cells and the production of antibodies [14,15].…”

Section: Introductionmentioning

confidence: 99%

Combination therapy of metformin with sodium selenite reverses effects of monotherapy on nitric oxide production, IL-1β and TNF-α release, and upregulates relative expression of Bcl-2 by LPS-activated human primary monocytes in T-cell acute lymphoblastic leukemia

Rostane

Sari

Bali

et al. 2022

Preprint

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Objectives: We examined the influence of the ex vivo combination therapy of metformin (Met, 1,1-dimethylbiguanide hydrochloride) with sodium selenite (Ss, Na2SeO3) on the changes in the production of nitric oxide (NO) and selected cytokines by circulating monocytes (MOs) during T-cell acute lymphoblastic leukemia (T-ALL). Methods: Assays were performed on MO cell samples isolated from children with T-ALL. Results: Met+Ss combination therapy reversed the Ss effect on the upregulation of NO production. Both Met+Ss and Ss treatment alone induced a significant downregulation of extracellular calcium ions consumption (ecCa2+) levels. Additionally, Met treatment induced a significant upregulation of IL-1β and TNF-α production; such effects were significantly reversed after combination with Ss treatment. Moreover, Met+Ss induced no significant effect on the production of IL-10, IL-6 and TNF-α, but a slight increase in IFN-γ levels. Furthermore, treatment with Ss alone induced a slight increase of IFN-γ. Finally, Met+Ss induced a marked upregulation of relative Bcl-2 expression in MOs. Conclusions: Met+Ss combination therapy results in downregulation of NO production, IL-1β and TNF-α release as well as in upregulation of the relative expression levels of Bcl-2-associated survival of primary MOs in human T-ALL.

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Immunomodulatory effects of selenium‐enriched peptides from soybean in cyclophosphamide‐induced immunosuppressed mice

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 26 publications

References 82 publications

Immunoregulatory activity of a low-molecular-weight heteropolysaccharide from Ganoderma leucocontextum fruiting bodies in vitro and in vivo

Immunoregulatory activity of a low-molecular-weight heteropolysaccharide from Ganoderma leucocontextum fruiting bodies in vitro and in vivo

A Comprehensive Comparison of Different Selenium Supplements: Mitigation of Heat Stress and Exercise Fatigue-Induced Liver Injury

Combination therapy of metformin with sodium selenite reverses effects of monotherapy on nitric oxide production, IL-1β and TNF-α release, and upregulates relative expression of Bcl-2 by LPS-activated human primary monocytes in T-cell acute lymphoblastic leukemia

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