Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum

Liu, Ying Zi; Cao, Yongluo; Ye, Jun Qing; Wang, Weiguang; Song, Ke; Wang, Xiaoliang; Wang, Chun Hua; Li, Rong Tao; Deng, Xiaoying

doi:10.1016/j.fitote.2009.08.005

Cited by 39 publications

(17 citation statements)

References 25 publications

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“…The RNA was reverse-transcribed into complementary DNA (cDNA) using a Revert Aid First Strand cDNA Synthesis Kit. The gene expressions of Bax and Bcl-2 were detected from the synthesized cDNA, as described elsewhere [22]. The primers are listed in Table 1.…”

Section: Quantitative Real-time Polymerase Chain Reactionmentioning

confidence: 99%

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

Zhang

Gao

Guo

et al. 2016

Biol Trace Elem Res

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Lead (Pb) exposure is a global environmental problem that can deplete body antioxidant enzymes, causing damage to various macromolecules and ultimately cell death. Pb exposure could lead to serious renal damage. Baicalin, a traditional Chinese medicine, could protect against renal injury through inhibition of oxidative stress and apoptosis. This study was designed to investigate the protective efficacy of baicalin against Pb-induced nephrotoxicity in mice and to elucidate the potential mechanisms using animal experiment. The results revealed that baicalin decreased Pb-induced bodyweight loss, declined kidney coefficients, and ameliorated renal function and structure in a dose-dependent manner. Meanwhile, baicalin dose dependently increased Pb-induced activity of SOD and GSH-Px, while the content of MDA in the kidney was decreased. In addition, baicalin enhanced the Bcl-2/Bax ratio associated with apoptosis in the kidney. These data indicated that further investigation of the use of baicalin as a new natural chemopreventive agent against Pd poisoning is warranted.

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Section: Quantitative Real-time Polymerase Chain Reactionmentioning

confidence: 99%

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

Zhang

Gao

Guo

et al. 2016

Biol Trace Elem Res

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“…Proanthocyanidins (PAs) are widely present in fruits, vegetables, nuts, seeds, flowers, and bark [1] and regarded as an important class of secondary metabolites in plants [2]. PAs are a group of naturally occurring polyphenolic bioflavonoids, specifically taking the form of oligomers or polymers of polyhydroxy flavan-3-ol units, such as (+)-catechin and (-)-epicatechin [3].…”

Section: Introductionmentioning

confidence: 99%

Comparison of methods for proanthocyanidin extraction from pine (Pinus densiflora) needles and biological activities of the extracts

et al. 2010

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Flavonoids are known to be effective scavengers of free radicals. In particular, proanthocyanidins are flavonoids that possess cardiovascular protection, antioxidative activities, and immunomodulatory activities. Here, we evaluated proanthocyanidin contents in the total polyphenolic compounds of pine needle extracts prepared by hot water, ethanol, hexane, hot water-hexane (HWH), and hot water-ethanol (HWE). Analysis of each extract indicated that the ethanol extract contained the highest proanthocyanidin concentration. The HWH and hexane extracts also contained relatively high concentrations of proanthocyanidin. On the other hand, proanthocyanidin content analyses out of the total polyphenolic compounds indicated that the HWH extract contained the highest content. These results suggest that HWH extraction is a suitable method to obtain an extract with a high level of pure proanthocyanidins and a relatively high yield. The HWH extract possessed superior activity in diverse antioxidative analyses such as 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelating (FIC), and ferric-ion reducing power (FRAP) assays. In addition, upon assessing the effects of the pine needle extracts on macrophages (Raw 264.7 cell), the HWH extract exhibited the highest activity. In this study, we discerned an efficient extraction method to achieve relatively pure proanthocyanidins from pine needles and evaluated the biological functions of the resulting extract, which could potentially be used for its efficacious components in functional food products.

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“…Some plants modulate both humoral and cell-mediated immunity, while others activate only the cellular components of the immune system. The evaluation of plants and/or products that either promote or inhibit immunocyte proliferation is crucial to the study of immunomodulation and drug discovery [13][14][15] . In this study we found 80% ethanol extract and butanol fraction of flowering aerial part of G. olivieri Griseb possess immunostimulant activity in experimental models of cellular and humoral immunity.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory activity of butanol fraction of Gentiana olivieri Griseb. on Balb/C mice

Singh¹,

Yadav²,

Noolvi³

2012

Asian Pacific Journal of Tropical Biomedicine

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Immunomodulatory effects of proanthocyanidin A-1 derived in vitro from Rhododendron spiciferum

Cited by 39 publications

References 25 publications

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

The Protective Effect of Baicalin Against Lead-Induced Renal Oxidative Damage in Mice

Comparison of methods for proanthocyanidin extraction from pine (Pinus densiflora) needles and biological activities of the extracts

Immunomodulatory activity of butanol fraction of Gentiana olivieri Griseb. on Balb/C mice

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