Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice

Bin-Hafeez, Bilal; Haque, Rizwanul; Parvez, Suhel; Pandey, Shivendra Kumar; Sayeed, Iqbal; Raisuddin, Sheikh

doi:10.1016/s1567-5769(02)00292-8

Cited by 213 publications

(149 citation statements)

References 28 publications

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“…The findings of the current study were similar with [38] who concluded that, Fenugreek extract in albino Swiss mice showed immune modulatory property through various mechanisms such as increase in relative organ weight of thymus, delayed type of hypersensitivity response, humoral immunity, increase in phagocytic index and phagocytic capacity of macrophages. Also, data obtained by [39] showed significant differences (p < 0.05) in lymphocyte, neutrophil, eosinophil, monocyte and highly significant difference (p < 0.05) in basophil ratios in response to fenugreek saponin ingestion.…”

Section: Immunological Parameterssupporting

confidence: 91%

Physiological Studies on the Effect of Fenugreek on Productive Performance of White New-Zealand Rabbit Does

Abdel-Rahman¹,

Fathalla²,

Assayed³

et al. 2016

FNS

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The objective of the current work is to investigate the possible beneficial effects of forced feeding of fenugreek to rabbit does on their milk composition, milk yield, anemia screening parameters, immunity and the growth performance of bunnies. Twenty white New Zealand female rabbits were randomly assigned into 5 groups: normal control and 4 treated groups (vehicle (molasses), fenugreek powdered seeds + molasses, sprouted fenugreek + molasses, and fenugreek oil + molasses). All treated groups took the given doses orally for two days before parturition and 13 days after parturition for 2 successive pregnancies. Blood samples were collected from each doe on the 13 th day of lactation for determination of hematological, biochemical and immunological parameters. Milk samples were taken for evaluation of milk composition. All rabbit does and their bunnies were weighed for calculation of the milk yield. The fenugreek seeds and oil administered groups (G 3 & G 5 ) recorded the highest percent values of fat, protein, lactose, total solids and solid not fat contents of the rabbits' milk in both 1 st and 2 nd lactation periods relative to other tested groups. At the beginning and mid of lactation periods, the milk yields recorded non-significant differences either between tested groups or between 1 st and 2 nd pregnancy in the same group. Whereas, at the end of lactation, germinated seeds (G 4 ) and oil (G 5 ) treated groups recorded significantly higher rates of milk yield relative to control and fenugreek seeds groups. Bunnies' body weights suckling from dams of group III (G 3 ) recorded the highest weights relative to other tested groups in both 1 st and 2 nd pregnancy. During the 1 st lactation period, all experimental groups showed significant reduction of white blood cells, while, G 3 and G 4 recorded significant elevation during 2 nd lactation period. Rabbits treated with fenugreek seeds powder (G 3 ) showed a signifiHow to cite this paper: Abdel-Rahman, H., Fathalla, S.I., Assayed, M.E., Masoad, S.R. 1277cant raise of phagocytic activity and phagocytic index. Fenugreek seeds group (G 3 ) and germinated one (G 4 ) showed significant red blood corpuscles and packed cell volume raise relative to other groups during both 1 st and 2 nd lactation periods.

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Section: Immunological Parameterssupporting

confidence: 91%

Physiological Studies on the Effect of Fenugreek on Productive Performance of White New-Zealand Rabbit Does

Abdel-Rahman¹,

Fathalla²,

Assayed³

et al. 2016

FNS

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“…It was reported that this agent significantly inhibited the antibody production of S-antigen induced experimental autoimmune uveitis in guinea pigs (28). Aqueous extract of Trigonella foenum graecum (L.), a widely used medicinal and dietary herb, shows a significantly stimulatory humoral immune response in mice (29). The polysaccharide extracts from 2 mushrooms, Lentinus edodes and Tremella fuciformis, and an herb, Astragalus membranaceus, on cellular and humoral immune responses also show significantly higher production of specific IgA, IgM, and IgG in chickens (30).…”

Section: Effects On Antibody Productionmentioning

confidence: 99%

The Immunopharmaceutical Effects and Mechanisms of Herb Medicine

Huang¹,

Lin

Liao

et al. 2008

Cell Mol Immunol

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In recent years, studies on evaluation of the therapeutic and toxic activity of herbal medicinal products became available and popular. The advances in modern biotechnology have led to discovery of many new active constituents. However, it is a constant challenge to establish the pharmacological basis for efficacy and safety of herbal medicinal products. A better understanding of the effects and bioavailability of phytopharmaceuticals can help in discovering suitable and rational therapies. In this review, we present the bioavailability studies in immune system that has been conducted for some of the more important or widely used phytopharmaceuticals. Furthermore, various new drug targets worthy of using for drug development in immunomodulating herbal medicine area and their regulatory mechanisms are also discussed. Adverse effects, drug interactions, and contraindications are also discussed which show that caution should be exercised when combining phytopharmaceuticals with chemically derived pharmaceutical components. Cellular & Molecular Immunology. 2008;5(1):23-31.

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“…This measurement was normalized by adhesion capacity, and although the adhesion capacity of the cells in Group 200 was 50% lower than that observed for the Control Group, the phagocytic capacity of adherent cells was still 3-fold greater. Together, these data indicate that the substances present in the barks of L. divaricata are able to stimulate a significant macrophage-mediated response, contributing to the body of evidence demonstrating that plant components influence immunomodulation by altering the phagocytic capacity of macrophages (Bin-Hafeez et al, 2003;Lee et al, 2007;Cruz et al, 2007) and other phagocytic cells (Nudo, Catap, 2011). However, a dose of 100 mg/kg did not elicit an impact on the adhesion and phagocytic capacity of isolated macrophages, suggesting an insufficient concentration of bioactive molecules to provide immunomodulation.…”

Section: Discussionmentioning

confidence: 67%

Anti-inflammatory, analgesic, and immunostimulatory effects of Luehea divaricata Mart. & Zucc. (Malvaceae) bark

Rosa

Nardi

Januário

et al. 2014

Braz. J. Pharm. Sci.

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Luehea divaricata (Malvaceae) is a plant widely used for treatment of various inflammatory and infectious conditions; however few reports discuss its biological properties. The aim of this study was to evaluate the anti-inflammatory and analgesic effects as well as the macrophage activity in mice treated with the hydroalcoholic crude extract of L. divaricata (CLD). Thin layer chromatography revealed presence of epicathequin, stigmasterol, lupeol and α,β-amyrin in the extract. To evaluate the anti-inflammatory and analgesic activities, animals were subjected to paw edema induced by carrageenan test, writhing, formalin and capsaicin tests. Immunomodulatory activity was evaluated by adhesion and phagocytic capacity, lysosomal volume, and reactive oxygen species (ROS) production by peritoneal macrophages, after daily treatment with CLD for 15 days. CLD promoted reduction in paw edema (36.8% and 50.2%; p<0.05 at doses of 100 and 300 mg/kg, respectively), inhibited writhing behavior at the higher dose (64.4%, p<0.05), reduced formalin reactivity (81.2% and 91.6% at doses of 100 and 300 mg/kg, respectively, p<0.05), and reduced capsaicin reactivity by 63.9% (300 mg/kg). CLD (200 mg·kg -1 ·day -1 ) increased phagocytosis capacity of macrophages (~3 fold, p<0.05), neutral red uptake (~50%, p<0.001), and ROS production (~90%, p<0.001). These data suggest that CLD possesses anti-inflammatory, analgesic and immunostimulatory properties. Luehea divaricata (Malvaceae) é utilizada para o tratamento de várias condições patológicas, entretanto, há poucos relatos sobre sua bioatividade. O objetivo deste estudo foi avaliar o efeito anti-inflamatório e analgésico, bem como a atividade de macrófagos em camundongos tratados com extrato bruto hidroalcoólico (CLD) da planta. Cromatografia em camada delgada revelou a presença de epicatequina, estigmasterol, lupeol e α,β-amirina no material. Para avaliar a atividade anti-inflamatória e analgésica, animais foram submetidos a teste de edema de pata induzido por carragenana, teste de contorções, da formalina e da capsaicina. A atividade imunomodulatória foi avaliada pela capacidade de adesão e de fagocitose dos macrófagos, volume lisossômico e produção de espécies reativas de oxigênio (ROS), após tratamento diário com CLD por 15 dias. CLD promoveu redução do edema de pata (36,8% e 50,2%; 100 e 300 mg/kg, respectivamente; p<0,05), redução do número de contorções (64,4%; 300 mg/kg; p<0,05), redução da reatividade no teste da formalina (81,2% e 91,6%; 100 e 300 mg/kg, respectivamente; p<0,05), e no teste da capsaicina em 63,9% (300 mg/kg). CLD (200 mg·kg Uniterms: Luehea divaricata

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Immunomodulatory effects of fenugreek (Trigonella foenum graecum L.) extract in mice

Cited by 213 publications

References 28 publications

Physiological Studies on the Effect of Fenugreek on Productive Performance of White New-Zealand Rabbit Does

Physiological Studies on the Effect of Fenugreek on Productive Performance of White New-Zealand Rabbit Does

The Immunopharmaceutical Effects and Mechanisms of Herb Medicine

Anti-inflammatory, analgesic, and immunostimulatory effects of Luehea divaricata Mart. & Zucc. (Malvaceae) bark

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