Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoni

Antiparasitic and physiological evaluation of Curcuma longa extract and/or PZQ on Schistosoma mansoni infected mice.

“…Allam (2009) reported that, infected mice treated with Curcumin restore the hepatic ALT and AST activities that were decreased by S. mansoni infection. This amelioration in the activities of liver enzymes could be attributed to the reduction in hepatic granuloma size and fibrosis as well as absence of necrotic hepatic tissue in infected treated mice (Allam, 2009). …”

Hepatoprotective and immunomodulatory properties of aqueous extract of Curcuma longa in carbon tetra chloride intoxicated Swiss albino mice

“…Curcumin treatment modulates cellular and humoral immune responses of infected mice and leads to a significant reduction of parasite burden and liver pathology in acute murine schistosomiasis mansoni [9] . Curcumin also downregulates matrix metalloproteinase (MMP)-2 and upregulates tissue inhibitor of metalloproteinase (TIMP)-1, two common effectors molecules involved in cell invasion [10] .…”

Activation of Nuclear Factor Erythroid 2-Related Factor 2 Cytoprotective Signaling by Curcumin Protect Primary Spinal Cord Astrocytes against Oxidative Toxicity

“…Once in the nucleus, Nrf2 binds to ARE and drives the transcription of downstream genes. 21) Curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione), a member of the curcuminoid family, is the major active component of turmeric, a yellow compound originally isolated from the plant Curcuma longa L. Curcumin has a number of biological and pharmacological activities such as anti-carcinogen, anti-angiogenic 22,23) anti-malarial, 24) antioxidant, anti-mutagenic, antibacterial, 25) immunemodulatory, 26) and anti-inflammatory. 27) However, whether it activates Nrf2 cytoprotective signaling and reduces the susceptibility of spinal cord astrocytes to oxidative damage have not been previously reported.…”