Immunomodulatory effects of a polysaccharide from Tamarindus indica

Sreelekha, T.T.; Vijayakumar, T.; Ankanthil, R; Vijayan, K.; Nair, Manjusha

doi:10.1097/00001813-199304000-00013

Cited by 46 publications

(25 citation statements)

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“…Extract of tamarind seeds used in this study have been shown to have better wound healing. This result was expected due to several consistent findings on immunomodulatory, anti-toxicity, anti-venom, and antioxidant activity of tamarind seeds (Sreelekha et al, 1993;Sano et al, 1996;Ieda et al, 1978).…”

Section: Discussionsupporting

confidence: 65%

“…Polysaccharide isolated from tamarind seeds has biological applications. It has immunomodulatory effect and lacks carcinogenic and cytotoxic activities (Sreelekha et al, 1993;Sano et al, 1996;Ieda et al, 1978). Water extract of tamarind seed was found to reduce blood sugar level in Streptozotocin-induced diabetic male rats (Maiti et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Tamarind Seed Extract Enhances Epidermal Wound Healing

Mohamad¹,

Akram²,

Bero³

et al. 2011

IJB

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Traditional healing power of tamarind fruits and the established antioxidant activity of the seeds drive the present study. Wound healing efficiency of tamarind seed was evaluated. Different solvents: phosphate buffer saline (PBS), water, methanol and ethanol were used to prepare the extract. Circular wound was inflicted on the nape. 10 µl of 5 µg/ml of extract was applied topically twice daily. Wound area was measured using Adobe ®Photoshop C3 Extended version and the percentage of wound reduction was calculated. PBS extract treatment induced complete wound healing in shortest period (10 days) while water extract, methanol extract and Solcoseryl ointment treatment induced complete wound healing in 11 days and control groups without any treatment took 14 days to heal. Phytochemical screening and Bradford method for protein quantification reveals the presence of alkaloid, saponin and tannin in all samples except PBS extract which tested negative to tannin. Flavonoid tested positive in methanol and ethanol extracts.

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Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Tamarind Seed Extract Enhances Epidermal Wound Healing

Mohamad¹,

Akram²,

Bero³

et al. 2011

IJB

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“…Tamarindus indica is traditionally very important herb having many important activities like antidiabetic 7 , analgesic 8 , antioxidant, hypolipidemic 9 , anti-inflammatory 10,11 , immunomodulatory 12 and antimicrobial activity 13,14 . Many important phytoconstituents responsible for the various activities were isolated.…”

Section: Tamarindus Indica Family: Fabaceae Subfamilymentioning

confidence: 99%

Potential of Various Extracts of Tamarindus indica (Caesalpiniaceae) Leaves in the Treatment of Cancer

Dhasade¹,

Nirmal²,

Pal³

et al. 2015

Insight Cancer Research

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Background and Objective:Globally second most frequently observed disease after heart disease is "Cancer". Despite advances in cancer treatment over the past decades, the prognosis of patients with blood cancer has improved only to small extent. Thus, there is an urgent need to develop new and effective strategies for the prevention and treatment of this form of cancer. Hence, present study was undertaken to evaluate anticancer potential of leaves of Tamarindus indica Linn. (Caesalpiniaceae). Materials and Methods: The plant leaves were collected and extracted with various solvents like petroleum ether, ethanol, ethyl acetate, chloroform and water. Various extracts of leaves were screened for anticancer activity using the methods like potato disc method, onion root-tip assay and trypan blue assay by using HL-60 Cell line in dose dependent manner. Results: Petroleum ether extract of leaves of T. indica shows more potency as compared with other extracts in the treatment of cancer in all the tests performed. Conclusion: It can be concluded that petroleum ether extract of T. indica leaves have potency to prevent or manage cancer cell growth.

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“…The polysaccharide was extracted from the dry pulp, following the method of Sreelekha et al (1993). Dry pulp (50 g) who added to de-ionized water (150-200 mL) at 4 C, the solution was filtered, and 70% ethanol (2.4 v=v) was added and kept under agitation for 12 h. The fraction not soluble in ethanol was separated by centrifugation at 30,000 rpm for 30 min.…”

Section: Extraction Of the T Indica Pulp Polysaccharide (Tpps)mentioning

confidence: 99%

ATamarindus indica. Linn Pulp Polysaccharide Inhibits FeverIn Vivo. and IL-1β Release by Murine Peritoneal Exudate Cells

Izquierdo

García-Tamayo

Soto

et al. 2007

Pharmaceutical Biology

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A water-soluble crude polysaccharide was obtained from the pulp of Tamarindus indica Linn. (Caesalpiniaceae) (TpPs). Gas chromatography analysis of a hydrolyzed sample confirmed the main chain of (1!4)-b-D-glucan, containing glucose, xylose, and galactose. TpPs was assayed in febrile rats and Balb=c mice. Pyrexia was induced in rats by subcutaneous yeast injection, and in mice with an intraperitoneal injection of a lipopolysaccharide (LPS) from Escherichia coli. Animals were treated with different oral TpPs doses (5-100 mg=kg). A significant dose-dependent reduction of the rectal temperature was observed. We also analyzed the effect on cytokines response to in vitro TpPs treatment in peritoneal exudates cells (PECs), as well as in response to LPS cell stimulation. IL-1b and IL-6 cytokines were measured in the supernatants through ELISA assays. Cells treated with LPS (10 mg=mL) or TpPs (100 mg=mL) alone resulted in a significant release of IL-1b. Our results indicate that, depending upon the experimental conditions, TpPs (0.005-0.5 mg=mL) abolished the IL-1b response to LPS cell stimulation, but at higher doses (50-100 mg=mL) increased it, and reduced significantly the IL-6 response. In febrile rats and Balb=c mice, TpPs did prevent fever in a dose-dependent manner. These preliminary findings show an in vitro modulating effect by TpPs in IL-1b profile at the local immune cellular level, and both febrifuge and hypothermic responses in a mouse model.

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Immunomodulatory effects of a polysaccharide from Tamarindus indica

Cited by 46 publications

References 0 publications

Tamarind Seed Extract Enhances Epidermal Wound Healing

Tamarind Seed Extract Enhances Epidermal Wound Healing

Potential of Various Extracts of Tamarindus indica (Caesalpiniaceae) Leaves in the Treatment of Cancer

ATamarindus indica. Linn Pulp Polysaccharide Inhibits FeverIn Vivo. and IL-1β Release by Murine Peritoneal Exudate Cells

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