Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice

Park, Jae Hyun; Lee, Jong Kwon; Kim, Hyung Soo; Chung, Seung Tae; Eom, Juno H.; Kim, Kyung A; Chung, Se Jin; Paik, Soon Young; Oh, Hye Young

doi:10.1016/j.intimp.2004.01.013

Cited by 150 publications

(89 citation statements)

References 25 publications

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“…Our findings showed that serum IgG and IgM concentrations in the birds receiving 700, 800, and 900 mg kg −1 of BG were significantly higher than those in control birds, suggesting that high levels of BG could modulate humoral immunity in broilers. Park et al (2004) found that BG supplementation activates the immune system in broilers, raising macrophage and natural killer cells activities, and increasing levels of cytokines (interleukin-1, interleukin-2, and interleukin-4). These cytokines enhance B-lymphocytes activities, which would be able to produce immunoglobulins (Banskota et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Effect of bee glue on growth performance and immune response of broiler chickens

Zafarnejad

Afzali

Rajabzadeh

2016

Journal of Applied Animal Research

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The objective of this experiment was to evaluate the effect of bee glue (BG) on the performance, relative visceral weights, some blood parameters, and immune status of broilers. A total of 200 male Ross 308 broiler chicks were randomly assigned to 5 dietary treatments: basal diet (BD), and basal diet supplemented with 600, 700, 800, and 900 mg kg −1 of BG. Each of the 5 diets was fed to 4 replicates of 10 chicks each from 0 to 42 days of age. The results indicated that the highest body weight, average daily gain, average daily feed intake, carcass weight, and carcass yield were observed in broilers offered 800 mg kg −1 of BG (P < .05). Inclusion of BG improved the feed conversion ratio compared with the control group (P < .01). The calculated European broiler index and crop percentage were greater for the birds received 800 and 900 mg kg −1 of BG compared with that of the control birds (P < .05). Inclusion of 900 mg kg −1 of BG significantly increased the relative weight of spleen and bursa, but reduced total triglycerides, cholesterol, LDL, and LDL: HDL ratio than the control group (P < .05). The serum IgG and IgM levels were increased for the birds received 700 to 900 mg kg −1 BG (P < .01), and addition of BG to the basal diet significantly increased antibody response against sheep red blood cell at 35 days of age (P < .05). It was concluded that an addition of 800 mg kg −1 BG to diet improves economic efficiency possibly by creating miniscule improvement in FCR and promoting immune response of broilers. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Effect of bee glue on growth performance and immune response of broiler chickens

Zafarnejad

Afzali

Rajabzadeh

2016

Journal of Applied Animal Research

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“…The rats were selected randomly divided into five groups each group consisting of five rats. The first group was given 0.5% (v/w) CAPE compound 20 mg/kg as a positive control [17]. Group II by granting distilled water as a negative control group, the group III, IV, and V was given liquid propolis with a dose of 0,16%, 0,46%, 1,44% of body weight/day.…”

Section: Animalsmentioning

confidence: 99%

Preliminary Studies of the Immunomodulator Effect of the Propolis Trigona spp. Extract in a Mouse Model

Kalsum¹

2017

IOSR JAVS

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Propolis helps boost the immune system naturally because propolis is rich in bioactive compounds and can help increase the production and activity of immune cells. This product has attracted the interest of researchers in recent decades because of the properties of biological and pharmacological, among others such as antimicrobial, antitumor, anti-inflammatory, antioxidant and immunomodulatory. One of bee species that potentially produce propolis in Indonesia is a local bee species Trigona spp. This study aimed to to determine the immunomodulatory effects of ethanol extract of propolis on the Sprague Dawley rats were infected by Staphylococcus aureus. Identification of the phytochemical compounds was undertaken to determine the bioactive compounds contained in propolis liquid. The effects of propolis were analyzed using the macrophage activity as determined by the phagocytic activity and by the production of nitric oxide (NO) in Sprague Dawley rat peritoneal macrophages and the production of antibodies. The results showed that the liquid propolis produces (a) an increase in the phagocytic index, (b) a significant increase in NO production, and (c)

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“…Tikus dipilih secara acak dibagi menjadi 5 kelompok, kelompok I pemberian 0,5% (v/b) senyawa CAPE 20 mg/kg sebagai kontrol positif, yang memiliki efek sebagai imunomodulator (Park 2004). Kelompok II pemberian akuades (ad libitum) sebagai kelompok kontrol negatif, kelompok III, IV, dan V pemberian dosis propolis cair 0,16%, 0,48%, 1,44% dari bobot badan/hari.…”

Section: Jumlah Dan Cara Pengambilan Sampelunclassified

Efek Propolis Cair Trigona spp. Terhadap Respons Imun Tikus Sprague Dawley yang Diinfeksi Sthapylococcus aureus

et al. 2017

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ABSTRAKPenelitian ini bertujuan untuk mengevaluasi efek pemberian propolis cair Trigona spp. terhadap parameter imunologi pada tikus yang diinfeksi Sthapylococcus aureus. Efek propolis dianalisis melalui aktivitas makrofag yang ditentukan oleh aktivitas fagositosis dan produksi Nitrit Oksida (NO) pada makrofag peritoneum tikus Sprague Dawley serta produksi antibodi. Hasil penelitian menunjukkan bahwa propolis cair menghasilkan (a) peningkatan indeks fagositik, (b) peningkatan yang signifikan produksi NO, dan (c) peningkatan produksi antibodi IgG. Studi ini menunjukkan bahwa ekstrak etanol propolis cair Trigona spp. mampu mengaktifkan makrofag, meningkatkan produksi NO dan antibodi. Kombinasi hasil ini menunjukkan bahwa ekstrak ini memiliki efek imunomodulator dan mampu meningkatkan respons imun.Kata kunci: aktivitas makrofag, antibodi, imunomodulator, propolis Trigona spp. 1978-1059 EISSN 2407-0920 DOI: 10.25182/jgp.2017.12.1.23-30 Terakreditasi SK Menristek Dikti 12/M/Kp/II/2015 PENDAHULUANSistem imun merupakan lini pertama pertahanan tubuh manusia, melindunginya dari penyakit dan mengobatinya apabila telah terjadi penyakit. Tubuh manusia secara terus menerus terpejan oleh berbagai faktor yang berdampak pada melemahnya fungsi sitem imun dan meningkatkan imunosupresi. Disfungsi sistem imun tubuh bertanggung jawab untuk patofisiologi dari banyak penyakit.Modulasi respons imun, baik dengan stimulasi sistem kekebalan tubuh atau dengan menekan reaksi imun yang tidak diinginkan, untuk meringankan penyakit tersebut, telah menarik beberapa peneliti selama bertahun-tahun. Terapi imunomodulator bisa memberikan alternatif untuk kemoterapi konvensional untuk berbagai kondisi sakit, terutama ketika mekanisme pertahanan inang harus diaktifkan pada kondisi respons imun terganggu. Penelitian terkait aplikasi imunostimulan sebagai aktivator sistem imun

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Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice

Cited by 150 publications

References 25 publications

Effect of bee glue on growth performance and immune response of broiler chickens

Effect of bee glue on growth performance and immune response of broiler chickens

Preliminary Studies of the Immunomodulator Effect of the Propolis Trigona spp. Extract in a Mouse Model

Efek Propolis Cair Trigona spp. Terhadap Respons Imun Tikus Sprague Dawley yang Diinfeksi Sthapylococcus aureus

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