Immunomodulatory drugs and their application to the management of canine immune‐mediated disease

Whitley, Nat; Day, M. J.

doi:10.1111/j.1748-5827.2011.01024.x

Cited by 108 publications

(170 citation statements)

References 165 publications

(170 reference statements)

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…Some dogs were refractory to prednisolone and cyclosporine treatment, but responded well to leflunomide. Leflunomide, which is a relatively new immunosuppressive drug for which few reports are available in dogs [34], is a potent agent and might be a good choice in the management of uncontrollable cases, although we could not confirm this hypothesis due to the small number cases in this study. Piroxicam has been reported to be an effective agent against rectal tubulopapillary polyps in dogs [15], but was less effective than immunosuppressive therapy in the present study.…”

Section: Discussioncontrasting

confidence: 53%

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Ohmi

Tsukamoto

Ohno

et al. 2012

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

ABSTRACT. Medical records of dogs with colorectal polyps were retrospectively reviewed, and clinical presentation of inflammatory colorectal polyps in miniature dachshunds was evaluated. Of 33 dogs found to have colorectal polyps, miniature dachshunds were markedly over-represented with 16 dogs (48%), of which 12 (75%) were found to have inflammatory polyps. Multiple polyps localized between the rectum and the descending colon was the most common finding in miniature dachshunds with inflammatory polyps. Twenty dogs (80%) out of 25 miniature dachshunds with inflammatory colorectal polyps responded to immunosuppressive therapy using prednisolone and cyclosporine. The results of this study indicate that miniature dachshunds are predisposed to develop inflammatory colorectal multiple polyps, for which immunosuppressive therapy may be a treatment option. Polyps are an abnormal growth of tissue arising from the mucosa, including neoplasms and inflammatory polyps. In dogs, colorectal polyps are relatively common in the gastrointestinal tract. These polyps can be single or multiple and are most often located in the distal rectum, causing the common clinical signs of hematochezia or tenesmus. In previous reports, many colorectal polyps in dogs were found to be derived from neoplasms, with adenomatous polyps and adenocarcinoma being most frequently represented [11,25,32,33]. Adenomatous polyps and adenocarcinoma are observed as solitary masses in the rectum, and most polyps appear as friable, lobulated, sessile, or pedunculated lesions on the mucosa. Surgical resection has been recommended in dogs as treatment for colorectal polyps [2,5,21]. Endoscopic treatment for adenomatous polyps [7,10] and piroxicam for tubulopapillary polyps [15] have been reported as alternative therapies for colorectal neoplasms. On the contrary, inflammatory colorectal polyps are rare, and few reports have described the clinical features of inflammatory colorectal polyps [33]. In humans, inflammatory colorectal polyps or polypoid lesions occur in association with inflammatory bowel disease (IBD) and other inflammatory diseases of the colon such as ischemic or infective colitis [3,17,24]. These masses form mainly due to extensive mucosal damage and healing processes, rather than infiltration of inflammatory cells. The polyps formed from infiltration of inflammatory cells, which could be termed "true" inflammatory polyps, seem to be relatively rare in humans.This study was conducted on the basis of two objectives. First, we retrospectively investigated dogs with colorectal polyps to characterize the prevalence and clinical features of the disease in Japan. Second, we reviewed the clinical presentation and treatment response of cases with inflammatory colorectal multiple polyps in miniature dachshunds, which were markedly over-represented in our study. MATERIALS AND METHODS Retrospective study of colorectal polyps in dogs:We reviewed the medical records of 33 dogs found to have colorectal polyps at the Veterinary Medical Center of the University of...

show abstract

Section: Discussioncontrasting

confidence: 53%

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Ohmi

Tsukamoto

Ohno

et al. 2012

The Journal of Veterinary Medical Science

View full text Add to dashboard Cite

show abstract

“…Although the efficacy of glucocorticoids in IMHA has never been investigated in a clinical trial, it is generally assumed that they are effective and their side-effects are taken for granted (Whitley and Day 2011). In contrast with recommendations for lifelong immunosuppression, the results of two studies suggest that immunosuppression for approximately 3 months is sufficient (Piek et al 2008(Piek et al , 2011.…”

Section: Immunomodulationmentioning

confidence: 51%

Canine idiopathic immune-mediated haemolytic anaemia: a review with recommendations for future research

Piek

2011

Veterinary Quarterly

View full text Add to dashboard Cite

“…Clearly it would be ill advised to embark upon a treatment protocol that included both steroids and non-steroidal anti-inflammatories (Whitely and Day 2011). It would therefore be useful to the clinician to have additional tools that might allow differentiation between those patients who are likely to respond to non-steroidal anti-inflammatory medication and those who may not.…”

Section: Discussionmentioning

confidence: 99%

Hypertrophic osteodystrophy in a dog imaged with CT

Hill¹,

Scudder

Glanemann

et al. 2015

Vet Record Case Reports

View full text Add to dashboard Cite

A seven-month-old male neutered cross-breed dog presented with non-specific signs of lethargy, pyrexia and pain on manipulation of the limbs, which progressed over a period of 24 hours to a non-ambulatory state with pain over multiple metaphyses. The patient underwent diagnostic imaging examinations, including radiography and CT, and arthrocentesis was performed, which demonstrated a sterile, neutrophilic infiltrate. On the basis of diagnostic tests, a diagnosis of hypertrophic osteodystrophy was made. The patient was managed initially with non-steroidal anti-inflammatory medication and adjunctive analgesia. The patient failed to respond to this protocol and hence was changed onto a tapering course of steroids initially at immunosuppressive levels to which he responded well. This case report provides the first description of hypertrophic osteodystrophy using CT and supports the use of arthrocentesis in the diagnostic plan for suspected cases of hypertrophic osteodystrophy in the dog.

show abstract

Immunomodulatory drugs and their application to the management of canine immune‐mediated disease

Cited by 108 publications

References 165 publications

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

A Retrospective Study of Inflammatory Colorectal Polyps in Miniature Dachshunds

Canine idiopathic immune-mediated haemolytic anaemia: a review with recommendations for future research

Hypertrophic osteodystrophy in a dog imaged with CT

Contact Info

Product

Resources

About