Canine idiopathic immune-mediated haemolytic anaemia: a review with recommendations for future research

Piek, Christine J.

doi:10.1080/01652176.2011.604979

Cited by 50 publications

(78 citation statements)

References 98 publications

(217 reference statements)

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“…Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http:// www.tandfonline.com/page/terms-and-conditions (Piek 2011), bee health and disease (Formato and Smulders 2011), basal glucose metabolism and peripheral insulin sensitivity in equine pituitary pars intermedia dysfunction (Klinkhamer et al 2011) and Enterococcus hiraeassociated endocarditis outbreaks in broiler flocks (Velkers et al 2011). Of note, all these papers were published in recent issues.…”

Section: Please Scroll Down For Articlementioning

confidence: 94%

Veterinary Quarterlyranks 30/143 in the top 25% of Veterinary Sciences category

Kolk¹

2012

Veterinary Quarterly

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Section: Please Scroll Down For Articlementioning

confidence: 94%

Veterinary Quarterlyranks 30/143 in the top 25% of Veterinary Sciences category

Kolk¹

2012

Veterinary Quarterly

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“…A similar mechanism may be triggered against endogenous antigens in the case of autoimmune hemolytic anaemia (AIHA), frequently seen in female large dog breeds, often in association with other auto-immune disorders (e.g. autoimmune thrombocytopenia, lupus erythematosus), in which the immune reaction is directed against erythrocyte antigens (McCullough, 2003;Piek, 2011). Moreover, IMHA may occur after transfusions with incompatible blood types or in neonatal isoerythrolysis.…”

Section: Macroscopic Appearance Of the Blood Samplementioning

confidence: 99%

The diagnostic approach to anaemia in the dog and cat

Paltrinieri

2017

J Hellenic Vet Med Soc

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The term anaemia indicates a pathologic condition characterized by a decreased concentration of hemoglobin (Hb) in blood, usually associated with a decreased number of erythrocytes (RBC) and/or of hematocrit (Ht). Anaemia depends on two pathogenic mechanisms: 1) decreased RBC production due toxic, infectious or idiopathic bone marrow diseases or to metabolic, neoplastic or infectious diseases that secondarily affect erythropoiesis, leading to the so-called "non regenerative anaemia", on which no reticulocytes are released in blood from bone marrow; 2) decreased lifespan of mature RBC due to acute blood loss or hemolysis that leads to "regenerative anaemia" in which reticulocytes are released in blood as an attempt to restore the RBC mass. A stepwise diagnostic approach to anaemic dogs and cats may allow first to identify which of the two mechanisms is involved in the pathogenesis of anaemia, then to identify the possible cause of decreased RBC production or of decreased RBC lifespan. This approach must include clinical data, information regarding gross appearance of the sample, actual values of RBC counts, Ht and Hb concentration, RBC indexes (MCV, MCH, MCHC, RDW) and the magnitude of the reticulocyte response. Morphology of blood cells and additional laboratory tests may further address the diagnosis. With rare exceptions, non regenerative anaemia is normocytic normochromic, while regenerative anaemia is macrocytic hypochromic and characterized by anisocytosis and polychromasia, since reticulocytes are larger and have less Hb than mature RBC. However, blood loss or hemolytic anaemia are initially "pre-regenerative" (normocytic and normochromic), then they shift to the macrocytic hypochromic pattern in a few days, when reticulocytosis becomes relevant. Microcytic hypochromic anaemia is usually associated with iron deficiency. Once anaemia is classified into one of the categories listed above, morphology of RBC may suggest the possible cause, especially in regenerative anaemia, when the shape of RBC may be consistent with oxidative damage (eccentrocytes, Heinz bodies), immune-mediated mechanisms (agglutination, spherocytes, schistocytes, etc) or infectious diseases (e.g. mycoplasmosis, babesiosis). If needed, bone marrow cytology, Coomb's test or flow cytometric detection of anti-RBC antibodies, coagulation profiles or additional biochemical or serological tests may be used to finalize the diagnostic approach. ΠΕΡΙΛΗΨΗ Η αναιμία είναι σύνδρομο που χαρακτηρίζεται από τη μείωση της συγκέντρωσης της αιμοσφαιρίνης σε συνδυασμό με τη μείωση του αριθμού των ερυθροκυττάρων και της τιμής του αιματοκρίτη. Με βάση παθοφυσιολογικά κριτήρια, η αναιμία ταξινομείται σε μη αναγεννητική, που χαρακτηρίζεται από την απουσία δικτυοερυθροκυττάρων (ΔΕΚ) λόγω μηδαμινής παραγωγής και

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“…In this edition, we publish a condensate of the literature on the clinical and clinicopathological features of canine IMHA, including a review of the risk factors for mortality (Piek 2011). The author emphasises that the prognosis of canine IMHA is poor, and may not have changed much in the last 40 years, despite the availability of immunosuppressive drugs that are more potent or more targeted than corticosteroids.…”

Section: Editorialmentioning

confidence: 99%

“…The year of the veterinarian: a call to celebrate, and to collaborate Dear reader, This year has been declared to be the ''Year of the Veterinarian'', in recognition and celebration of 250 years of veterinary education and the profession (Comite´-Vet2011 2008-2011. Progress in veterinary science has paralleled that in human medical science, and appears to have increased logarithmically since the early days of servicing Napoleon's cavalry.…”

Section: Editorialmentioning

confidence: 99%

The year of the veterinarian: a call to celebrate, and to collaborate

Cave

2011

Veterinary Quarterly

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Canine idiopathic immune-mediated haemolytic anaemia: a review with recommendations for future research

Cited by 50 publications

References 98 publications

Veterinary Quarterlyranks 30/143 in the top 25% of Veterinary Sciences category

Veterinary Quarterlyranks 30/143 in the top 25% of Veterinary Sciences category

The diagnostic approach to anaemia in the dog and cat

The year of the veterinarian: a call to celebrate, and to collaborate

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