Immunomodulatory and Therapeutic Potential of Marine Flora Products in the Treatment of Cancer

Singh, Anshika; Krishna, Sudhir

doi:10.1007/978-981-13-7607-8_7

Cited by 5 publications

(6 citation statements)

References 176 publications

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“…are the persuasive antitumor chemical representatives which can act as encouraging anticancerous agent (Haq et al 2019 ). Moreover, cryptophycin 1 and borophycin isolated from Nostoc indicated anti-tumorigenic activity against human tumor cells, and KB and LoVo cell lines, respectively (Singh and Krishna 2019 ). Recently, it has been reported that methanolic extract (T1) of H. pulvialis showed anticancerous activity by suppressing invasion of breast cancer cells (MDA-MB-231) and promoting apoptosis through biochemical pathway involving p53/Bax/Bcl2 (Alateyah et al 2022 ).…”

Section: Microalgal Bioactive Compounds and Their Potential Biologica...mentioning

confidence: 99%

Microalgal bioactive metabolites as promising implements in nutraceuticals and pharmaceuticals: inspiring therapy for health benefits

et al. 2023

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The rapid increase in global population and shrinkage of agricultural land necessitates the use of cost-effective renewable sources as alternative to excessive resource-demanding agricultural crops. Microalgae seem to be a potential substitute as it rapidly produces large biomass that can serve as a good source of various functional ingredients that are not produced/synthesized inside the human body and high-value nonessential bioactive compounds. Microalgae-derived bioactive metabolites possess various bioactivities including antioxidant, anti-inflammatory, antimicrobial, anti-carcinogenic, anti-hypertensive, anti-lipidemic, and anti-diabetic activities, thereof rapidly elevating their demand as interesting option in pharmaceuticals, nutraceuticals and functional foods industries for developing new products. However, their utilization in these sectors has been limited. This demands more research to explore the functionality of microalgae derived functional ingredients. Therefore, in this review, we intended to furnish up-to-date knowledge on prospects of bioactive metabolites from microalgae, their bioactivities related to health, the process of microalgae cultivation and harvesting, extraction and purification of bioactive metabolites, role as dietary supplements or functional food, their commercial applications in nutritional and pharmaceutical industries and the challenges in this area of research. Graphical abstract

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Section: Microalgal Bioactive Compounds and Their Potential Biologica...mentioning

confidence: 99%

Microalgal bioactive metabolites as promising implements in nutraceuticals and pharmaceuticals: inspiring therapy for health benefits

et al. 2023

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“…Worthy of mention is that several anticancer drugs of marine origin are in clinical use with sufficient approvals, including cytarabine, vidarabine, nelarabine, fludarabine phosphate, trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumabvedotin, enfortumabvedotin, belantamabmafodotin, plitidepsin, lurbinectedin, bryostatins, discodermolide, eleutherobin, and sarcodictyin [41,58]. such as Lactobacilli and Bifidobacteria, modify the mucosa by increasing the production of chemokines and host defense peptides, inducing dendritic cell maturation, and increasing cell proliferation and apoptosis [51]. Marine probiotics can modulate cancer by inducing apoptosis, inhibiting mutagenic activity, downregulating oncogene expression, inducing autophagy, inhibiting kinases, reactivating tumor suppressors, preventing metastasis, and producing meta-biotics, as already shown in B. animalis, B. infantis, B. bifidum, L. paracasei, L. acidophilus, and L. plantarum I-UL4 against MFC7 cancer cells [53,54].…”

Section: Marine Probiotics and General Therapeutic Potentialsmentioning

confidence: 99%

“…Trioxacarcins A–C, anthraquinone, Macrodiolide tartrolon D, and Streptokordin obtained from Streptomyces spp. exhibited significant antitumor/cytotoxic activities against various cancer cell lines [ 50 , 51 , 52 ].…”

Section: Marine Probiotics and General Therapeutic Potentialsmentioning

confidence: 99%

“…These components optimize various physiological functions of the host, including regulatory, metabolic, and behavioral reactions. Marine probiotics, such as Lactobacilli and Bifidobacteria , modify the mucosa by increasing the production of chemokines and host defense peptides, inducing dendritic cell maturation, and increasing cell proliferation and apoptosis [ 51 ]. Marine probiotics can modulate cancer by inducing apoptosis, inhibiting mutagenic activity, downregulating oncogene expression, inducing autophagy, inhibiting kinases, reactivating tumor suppressors, preventing metastasis, and producing meta-biotics, as already shown in B. animalis , B. infantis , B. bifidum , L. paracasei , L. acidophilus , and L. plantarum I-UL4 against MFC7 cancer cells [ 53 , 54 ].…”

Section: Marine Probiotics and General Therapeutic Potentialsmentioning

confidence: 99%

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Therapeutic Potential of Marine Probiotics: A Survey on the Anticancer and Antibacterial Effects of Pseudoalteromonas spp.

et al. 2023

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Due to the increasing limitations and negative impacts of the current options for preventing and managing diseases, including chemotherapeutic drugs and radiation, alternative therapies are needed, especially ones utilizing and maximizing natural products (NPs). NPs abound with diverse bioactive primary and secondary metabolites and compounds with therapeutic properties. Marine probiotics are beneficial microorganisms that inhabit marine environments and can benefit their hosts by improving health, growth, and disease resistance. Several studies have shown they possess potential bioactive and therapeutic actions against diverse disease conditions, thus opening the way for possible exploitation of their benefits through their application. Pseudoalteromonas spp. are a widely distributed heterotrophic, flagellated, non-spore-forming, rod-shaped, and gram-negative marine probiotic bacteria species with reported therapeutic capabilities, including anti-cancer and -bacterial effects. This review discusses the basic concepts of marine probiotics and their therapeutic effects. Additionally, a survey of the anticancer and antibacterial effects of Pseudoalteromonas spp. is presented. Finally, marine probiotic production, advances, prospects, and future perspectives is presented.

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“…An immunomodulator is a compound that can modify the activity of the immune system by enhancing or suppressing the host response and are categorized as an Immunostimulant, immunosuppressant and immunoadjuvant (Sindhu et al 2021). Several products of marine organisms, including microalgae, exhibit immunomodulatory activity (Singh and Krishna 2019). Indonesia has been known as a maritime country that is rich in biodiversity of organisms, including marine organisms and microalgae.…”

Section: Introductionmentioning

confidence: 99%

The immunomodulatory effect of Glagah consortium microalgae polysaccharides based on splenocyte proliferation and cytokine production in vitro

Afililla

Suwanti²,

MUFASIRIN³

et al. 2022

Biodiversitas

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Abstract. Afililla Z, Suwanti LT, Mufasirin, Koerniawan HP, Suyono EA, Budiman A, Siregar UJ. 2022. The immunomodulatory effect of Glagah consortium microalgae polysaccharides based on splenocyte proliferation and cytokine production in vitro. Biodiversitas 23: 5205-5209. Indonesia is known as a maritime country that has various organisms, including microalgae. Some microalgae have many bioactivities, such as immunomodulatory activity. This study aimed to determine Glagah consortium microalgae polysaccharide (GCMP) and polysaccharide of Spirulina platensis (PSP) as an immunomodulator based on its effect on splenocyte proliferation and cytokine production in vitro. Crude polysaccharides were extracted by lye extraction method. Splenocytes were obtained from spleen of healthy mice and cultured in RPMI 1640 medium with and without Concanavalin A (Con A). Cells (3×105 per well) were treated with polysaccharide with dose gradually 0, 1.25, 2.5, 10 and 20 µg/mL. Splenocytes proliferation were observed by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. The supernatant was taken for the detection of cytokines using enzyme-linked immunoassay (ELISA). The results showed that GCMP, both with and without Con A at a concentration of less than 10 mg/mL decreased cell viability, on the other hand, a concentration of 10-20 mg/mL had a proliferative effect. Splenocytes were shown a proliferative effect at all concentrations of PSP, both with and without Con A. The concentration of polysaccharides, both GCMP and PSP, did not affect cytokine levels. In conclusion, based on the proliferation of splenocytes, GCMP has an immunomodulatory effect depending on its concentration.

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Immunomodulatory and Therapeutic Potential of Marine Flora Products in the Treatment of Cancer

Cited by 5 publications

References 176 publications

Microalgal bioactive metabolites as promising implements in nutraceuticals and pharmaceuticals: inspiring therapy for health benefits

Microalgal bioactive metabolites as promising implements in nutraceuticals and pharmaceuticals: inspiring therapy for health benefits

Therapeutic Potential of Marine Probiotics: A Survey on the Anticancer and Antibacterial Effects of Pseudoalteromonas spp.

The immunomodulatory effect of Glagah consortium microalgae polysaccharides based on splenocyte proliferation and cytokine production in vitro

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