Immunomodulatory and anti-SARS activities of Houttuynia cordata

Lau, Kin Mang; Lee, Kin Ming; Koon, Chi Man; Cheung, Catherine; Lau, Chak‐Sing; Ho, Hei Ming Kenneth; Lee, Mavis Yuk Ha; Au, Shannon Wing Ngor; Chen, Cheng; Lau, Clara Bik San; Wan, David Chi Cheong; Waye, Mary Miu Yee; Wong, Kam-Bo; Wong, Chun Kwok; Lam, Christopher Wai Kei; Leung, Ping Chung; Fung, Kwok‐Pui

doi:10.1016/j.jep.2008.03.018

Cited by 285 publications

(250 citation statements)

References 26 publications

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“…(Saururaceae) is a perennial herb native to Southeast Asia with immense medicinal values. Traditionally, H. cordata is used for diuresis, detoxification, anti-viral, anti-bacterial, antileukemic, allergies, anaphylaxis and to tackle severe acute respiratory syndrome (Lai et al, 2010;Li et al, 2005;Lau et al, 2008;Lee et al, 2008). Recently, we reported that the ethanol fraction of H. cordata ethyl acetate (HC-EA) possess strong anti-oxidant and anti-neuroinflammatory properties (Park et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Houttuynia cordataalleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Kang

Koppula

2014

Pharmaceutical Biology

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Context: Houttuynia cordata Thunb. (Saururaceae) is used traditionally in Asian countries to treat various disease symptoms. Objective: To study the effect of H. cordata ethyl acetate (HC-EA) extract on high-fat diet (HFD)-induced hepatic steatosis. Materials and methods: HFD fed rats were orally dosed with HC-EA (100, 200, or 300 mg/kg) once daily for 8 weeks and the lipid profiles and protein expressions in hepatocytes were evaluated. Results: HFD rats showed an increase (p50.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), free fatty acids (FFAs), and reduced the high-density lipoprotein (HDL) levels. Treatment with HC-EA extract (300 mg/kg) restored the changes in plasma lipid levels of TC, TG, LDL, FFA, and HDL in HFD-fed rats by 34.8, 31.1, 51.4, 32.4, and 56.3%, respectively, compared with control rats (p50.01). HC-EA treatment also decreased the hepatic lipid accumulation (p50.001 at 300 mg/kg) and improved hepatic histological lesions. HC-EA extract enhanced AMPK phosphorylation and its primary downstream targeting enzyme, acetyl-CoA carboxylase (ACC), up-regulated the gene expression of carnitine palmitoyl transferase-1 (CPT-1), and down-regulated sterol regulatory element binding protein 1, fatty acid synthase, and glutamate pyruvate transaminase protein levels in the livers of HFD-fed rats. Further, the increased expression of hepatic cytochrome P450 (CYP) composition such as CYP2E1 and CYP4A was also suppressed. Discussion and conclusion: Data suggest that HC-EA extract might act by regulating the AMPK-dependent pathway and related mediators and might be used in treating obesity-related liver diseases.

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Section: Introductionmentioning

confidence: 99%

Houttuynia cordataalleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Kang

Koppula

2014

Pharmaceutical Biology

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“…Quercetin 3-O-methyl ether and ophioglonin obtained from plants belonging to Ophioglossaceae genus have shown slight activity against HBV [50]. Since 1995 when antiviral activities against enveloped viruses were discovered in extracts of Houttuynia cordata [51], such as influenza, HIV, herpes, SARS and also in enteroviruses [51][52][53][54], 40 compounds have been isolated from the whole plant [55].…”

Section: Resultsmentioning

confidence: 99%

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

et al. 2011

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Abstract:In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)-a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosomes (Trypanosoma brucei brucei) and several cancer cell lines were identified. Six aqueous extracts from Celosia cristata, Ophioglossum vulgatum, Houttuynia cordata, Selaginella tamariscina, Alpinia galanga and Alpinia oxyphylla showed significant antiviral effects against BVDV without toxic effects on host embryonic bovine trachea (EBTr) cells, while Evodia lepta, Hedyotis Moreover, among fifteen water extracts that combined high antiproliferative activity (IC 50 0.5-20 µg/mL) and low acute in vitro toxicity (0-10% reduction in cell viability at IC 50 ), Coptis chinensis presented the best beneficial characteristics. In conclusion, traditional herbal medicine from Europe and China still has a potential for new therapeutic targets and therapeutic applications.

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“…It has been reported that H. cordata has anti-microbial, immunostimulatory, diuretic, anticancer, sedative, anti-inflammatory, anti-allergic and antitussive effects (Park et al, 2005;Li et al, 2005;Lu et al, 2006;Kim et al, 2007). H. cordata has antiviral activities against herpes simplex virus type 1 (HSV-1), influenza virus and HIV as well as SARS-CoV (Hayashi et al, 1995;Chiang et al, 2003;Ono et al, 2006;Lau et al, 2008). Because H. cordata is very cheap and easily available in China and it may be one prospective natural products that can be used for treating PrV infection.…”

Section: Research Articlementioning

confidence: 99%

The effect ofHouttuynia cordatainjection on pseudorabies herpesvirus (PrV) infectionin vitro

Ren

Sui

Yin

2010

Pharmaceutical Biology

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Immunomodulatory and anti-SARS activities of Houttuynia cordata

Abstract: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS.

Cited by 285 publications

References 26 publications

Houttuynia cordataalleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Houttuynia cordataalleviates high-fat diet-induced non-alcoholic fatty liver in experimental rats

Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

The effect ofHouttuynia cordatainjection on pseudorabies herpesvirus (PrV) infectionin vitro

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