Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions

Majdalawieh, Amin F.; Yousef, Sarah M.; Abu‐Yousef, Imad A.; Nasrallah, Gheyath K.

doi:10.1080/10408398.2021.1881438

Cited by 32 publications

(25 citation statements)

References 99 publications

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“…20,21 Sesamin (Ses), a fat-soluble lignin isolated from sesame seeds and sesame oil, has attracted considerable attention owing to its wide range of biological and pharmacological activities, including antioxidant, anti-inflammatory, and anticarcinogenic activities. 22 However, the effects of Ses on PM 2.5 -induced cardiovascular toxicity remain unclear. Moreover, the underlying mechanism must be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Sesamin attenuates PM_2.5-induced cardiovascular injury by inhibiting ferroptosis in rats

Ren

Yin

et al. 2021

Food Funct.

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Section: Introductionmentioning

confidence: 99%

Sesamin attenuates PM_2.5-induced cardiovascular injury by inhibiting ferroptosis in rats

Ren

Yin

et al. 2021

Food Funct.

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“…Therefore, we paid an attention to sesamin, a phytochemical with numerous reported beneficial effects on diabetes and its brain complications. Sesamin is a type of lignans extracted from sesame seed oil ( Sesamum indicum ) and its powerful antioxidant and anti-inflammatory properties were approved by various studies 28 , 68 , 69 . Since there are in vivo affirmations of the blood–brain barrier permeability of sesamin 70 , recent researches focused on the neuroprotective effects of this compound.…”

Section: Discussionmentioning

confidence: 99%

Sesamin protects against neurotoxicity via inhibition of microglial activation under high glucose circumstances through modulating p38 and JNK signaling pathways

Kongtawelert

Kaewmool

Phitak

et al. 2022

Sci Rep

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Diabetes mellitus (DM), one of the principal causes of morbidity and mortality worldwide, is implicated in the progression of age-related neurodegenerative diseases (NDDs), in which microglial activation is a crucial mediator. Sesamin, a kind of phytochemical, shows inhibitory effects on microglial activation. The present study studied whether sesamin protects against neurotoxicity triggered by high glucose-induced microglial activation. We firstly demonstrated that high doses of glucose, which mimics hyperglycemia in DM, did induce the activation of murine BV2 microglial cells, increasing inflammatory responses such as the production of ROS or inflammatory mediators like IL-1β, TNF-⍺, and nitric oxide, through activation of p38 and JNK signaling pathways. Next, conditioned medium (CM) collected from high glucose-activated BV2 cell culture was used to show aggravated neurotoxicity in differentiated PC12 cells, indicating that high glucose-activated microglia could induce neurotoxicity. Interestingly, pretreatment of BV2 cells with sesamin diminished high glucose-induced microglia activation and inflammatory responses. Moreover, neurotoxicity in PC12 cells was found to be decreased in the group treated with CM from the sesamin-pretreated BV2 cell culture, suggesting sesamin inhibited microglial activation, thereby protecting neurons from activated microglia-mediated neurotoxicity. Thus, sesamin might be a potential compound to use in the prevention of diabetic-induced NDDs.

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“…Sesamin can significantly reduce IL-6 and IL-1 mRNA expression in human primary synovial fibroblasts, indicating that sesamin can block TNF-α induced pro-inflammatory cytokine mRNA expression. [ 53 ]…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism involved may be due to the fact that it interferes with the early signal transduction of TNF-α, thereby affecting the activation of nuclear factor kappa-B. Sesamin can significantly reduce IL-6 and IL-1 mRNA expression in human primary synovial fibroblasts, indicating that sesamin can block TNF-α induced pro-inflammatory cytokine mRNA expression [53] …”

Section: Discussionmentioning

confidence: 99%

Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking

Huang

et al. 2021

Medicine

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Background: The traditional Chinese medicine prescription Suhexiang Pill (SHXP), a classic prescription for the treatment of plague, has been recommended in the 2019 Guideline for coronavirus disease 2019 (COVID-19) diagnosis and treatment of a severe type of COVID-19. However, the bioactive compounds and underlying mechanisms of SHXP for COVID-19 prevention and treatment have not yet been elucidated. This study investigates the mechanisms of SHXP in the treatment of COVID-19 based on network pharmacology and molecular docking. Methods: First, the bioactive ingredients and corresponding target genes of the SHXP were screened from the traditional Chinese medicine systems pharmacology database and analysis platform database. Then, we compiled COVID-19 disease targets from the GeneCards gene database and literature search. Subsequently, we constructed the core compound-target network, the protein-protein interaction network of the intersection of compound targets and disease targets, the drug-core compound-hub gene-pathway network, module analysis, and hub gene search by the Cytoscape software. The Metascape database and R language software were applied to analyze gene ontology biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. Finally, AutoDock software was used for molecular docking of hub genes and core compounds. Results: A total of 326 compounds, 2450 target genes of SHXP, and 251 genes related to COVID-19 were collected, among which there were 6 hub genes of SHXP associated with the treatment of COVID-19, namely interleukin 6, interleukin 10, vascular endothelial growth factor A, signal transducer and activator of transcription 3 (STAT3), tumor necrosis factor (TNF), and epidermal growth factor. Functional enrichment analysis suggested that the effect of SHXP against COVID-19 is mediated by synergistic regulation of several biological signaling pathways, including Janus kinase/ STAT3, phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt), T cell receptor, TNF, Nuclear factor kappa-B, Toll-like receptor, interleukin 17, Chemokine, and hypoxia-inducible factor 1 signaling pathways. SHXP may play a vital role in the treatment of COVID-19 by suppressing the inflammatory storm, regulating immune function, and resisting viral invasion. Furthermore, the molecular docking results showed an excellent binding affinity between the core compounds and the hub genes. Conclusion: This study preliminarily predicted the potential therapeutic targets, signaling pathways, and molecular mechanisms of SHXP in the treatment of severe COVID-19, which include the moderate immune system, relieves the “cytokine storm,” and anti-viral entry into cells.

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Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions

Cited by 32 publications

References 99 publications

Sesamin attenuates PM_2.5-induced cardiovascular injury by inhibiting ferroptosis in rats

Sesamin attenuates PM_2.5-induced cardiovascular injury by inhibiting ferroptosis in rats

Sesamin protects against neurotoxicity via inhibition of microglial activation under high glucose circumstances through modulating p38 and JNK signaling pathways

Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking

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Immunomodulatory and anti-inflammatory effects of sesamin: mechanisms of action and future directions

Cited by 32 publications

References 99 publications

Sesamin attenuates PM2.5-induced cardiovascular injury by inhibiting ferroptosis in rats

Sesamin attenuates PM2.5-induced cardiovascular injury by inhibiting ferroptosis in rats

Sesamin protects against neurotoxicity via inhibition of microglial activation under high glucose circumstances through modulating p38 and JNK signaling pathways

Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking

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Product

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About

Sesamin attenuates PM_2.5-induced cardiovascular injury by inhibiting ferroptosis in rats

Sesamin attenuates PM_2.5-induced cardiovascular injury by inhibiting ferroptosis in rats