Immunomodulatory activities of the ethanolic extract of Caesalpinia bonducella seeds

Shukla̽, Shruti; Mehta, Archana; John, Jinu; Mehta, P.; Vyas, Suresh P.; Shukla, Satish

doi:10.1016/j.jep.2009.07.002

Cited by 76 publications

(50 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…20 It has been reported to have antiinflammatory, antipyretic, analgesic, antioxidant, antibacterial, antifilarial, antiasthamatic, antitumor, anxiolytic 18 , immunomodulatory and hepatoprotective properties. [21][22][23][24][25] Some other study reports also confirmed the hypolipidemic action of the seed extract and additional benefits in the diabetic condition. Apart from that there are some reports showing hypoglycemic and antidiabetic activity of the extracts of its seeds kernel.…”

mentioning

confidence: 83%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

Evidence implicates hyperglycemia induced oxidative stress as a key factor in the pathogenesis of both microvascular and macrovascular complications in the body. Our main objective behind this study was to explore the beneficial effect of Caesalpinia bonducella seed kernel extract on Streptozotocin-induced hyperglycaemia and oxidative damage in rats. Rats were made hyperglycemic by single intravenous injection of Streptozotocin 40mg/kg of body weight. Hyperglycemic rats treated with extract in three different doses of 200, 400 and 600 mg/kg of body weight orally for 21 days shows a significant decrease in blood glucose, HbA1c, free amino groups whereas an increase in serum insulin level, liver glycogen contents with a significant improvement in glucose tolerance. Furthermore, above extract supplementation significantly decreases the pancreatic thiobarbituric acid-reactive substances levels along with an increase in superoxide dismutase, catalase and glutathione contents in pancreatic tissues in treatment groups when compared with control hyperglycemic rats. Treatment with above extract has lessened the severities of degenerative changes in pancreas and also in the liver tissues as compared to that of untreated control rat with hyperglycemia. Our results suggest that the ethanolic extract of Caesalpinia bonducella seed kernel improves the antioxidant defense under hyperglycemic condition and also exhibit strong anti-hyperglycaemic effect in dose dependent manner.

show abstract

mentioning

confidence: 83%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

show abstract

“…Hemagglutination was observed under the microscope after incubation of the plates at 37°C for 1 h. Reciprocal of the highest dilution of the test serum agglutination was treated as antibody result. 3,14,15 Right hind foot pad was encountered with 0.5 × 10 9 SRBCs cells. After +24 and +48 h of this treatment period, foot thickness was monitored with vernier calipers.…”

Section: Hemagglutination Antibody (Ha) Titrementioning

confidence: 99%

Quantification of rutin and quercetin by HPTLC/HPLC and in vitro immunomodulatory and anticancer activities of Capparis moonii fruits extracts

Doshi

Pawar

Chavda

2017

Int J Basic Clin Pharmacol

View full text Add to dashboard Cite

Background: The current research was undertaken on dried fruits of Capparis moonii to screen its potential for immunomodulatory and cancer indications with identification of phytoconstituents by chromatographic techniques.Methods: Methanolic (MECN), hydro-methanolic (HMECN) and aqueous extracts (AQCN) of Capparis moonii were subjected to high performance thin layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC) after studying the total phenolic and flavonoid content by using rutin and gallic acid as standards respectively as well as undertaking powder characteristics and preliminary phytochemical screening. Immunomodulatory activities covered were hemagglutination antibody titre and delayed-type hypersensitivity reaction with the aid of sheep red blood cells (0.5×109) as antigens. The extracts were studied for antioxidant potential. Anticancer prospects were focusing on in vitro cell lines screening (MCF 7 and HCT 15) by Sulforhodamine B assay method and potato disc assay.Results: The total phenolic and flavonoid content of MECM, HMECM and AQCM fruits extracts were found to be 0.20, 0.11 and 0.47 mg of gallic acid/g and 78.3, 18.8 and 64.4 mg of rutin/g respectively. Rutin and quercetin were confirmed by HPTLC and HPLC showing well resolved peaks. IC50 values in antioxidant studies were found to be significant with all the extracts. Significant immunomodulatory effect was noticed at 200mg/kg in both models (high antibody titre levels and decrease paw volume after 48 h). Unsatisfactory results were observed with selected cell lines and disc assay.Conclusions: Thus, selected fruits may probably have immunomodulatory potential due to presence of flavonols (rutin and quercetin).

show abstract

“…A number of medicinal plants have been reported globally and are used by the traditional herbalists and the various communities' in the modulation of the immune system in both developing and developed countries (Gokin et al, 2000). Modulation of the immune system responses to alleviate disease conditions has been of medical interest worldwide for many years (Maizels, 2009;Shuklaa et al, 2009). Currently there is increased scientific interest in agents that can modulate the immune system in severely immunocompromised individuals like in cases of human immunodeficiency virus (HIV) infected individual, stress, malnutrition and many others (Shuklaa et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Modulation of the immune system responses to alleviate disease conditions has been of medical interest worldwide for many years (Maizels, 2009;Shuklaa et al, 2009). Currently there is increased scientific interest in agents that can modulate the immune system in severely immunocompromised individuals like in cases of human immunodeficiency virus (HIV) infected individual, stress, malnutrition and many others (Shuklaa et al, 2009). The available immunosuppressive and immunostimulating agents have limitations; including adverse drug reactions and toxicities, as well as increased risk of infection due to their prolonged use in case they cause immunosuppression.…”

Section: Introductionmentioning

confidence: 99%

Effect of the total crude extracts of Hibiscus sabdariffa on the immune system in the Wistar albino rats

Lubega¹

2013

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Medicinal herbs are commonly used worldwide as immune boosters and immunomodulators in the management of various disease conditions. Many of these herbs commonly used have not been scientifically evaluated for their immune modulating activities. The study investigated the immunomodulatory activity of the total crude leaf extract of Hibiscus sabdariffa in Wistar albino rats. It was an experimental study that was conducted on four groups of animals each with 6 healthy adult rats. Group I was dosed each with 1mL of normal saline. Groups II, III and IV were dosed 1mL of 125, 250 and 500 mg/Kg bwt of total crude extract, daily for 14 days respectively. On the 15 th day, whole blood was collected into a clean ethlenediaminetetracetic acid (EDTA)-vacutainer. The complete blood count (CBC), immune blood cell count, hemagglutination antibody (HA) titers, neutrophil adhesion and delayed-type hypersensitivity (DTH) response were determined. All the doses caused an increase in mean red blood cell (RBC) counts as compared to control group. Similarly, the mean percentage neutrophils, monocytes, basophils and eosinophils increased with dose while the opposite was true for percentage lymphocytes. The mean HA titers for the herb were higher than control though no statistical difference (p≥0.05) was observed. Similar effects were observed with neutrophil adhesions response as that of HA titers. For DTH, the highest footpad thickness (175.2% increment) was observed at a dose of 500 mg/Kg bwt after 12 h and was statistically significant (p≤0.05) as compared to control. H. sabdariffa contain compounds with immunomodulatory activity in Wistar albino rats.

show abstract

Immunomodulatory activities of the ethanolic extract of Caesalpinia bonducella seeds

Cited by 76 publications

References 13 publications

Untitled

Untitled

Quantification of rutin and quercetin by HPTLC/HPLC and in vitro immunomodulatory and anticancer activities of Capparis moonii fruits extracts

Effect of the total crude extracts of Hibiscus sabdariffa on the immune system in the Wistar albino rats

Contact Info

Product

Resources

About