Quantification of rutin and quercetin by HPTLC/HPLC and in vitro immunomodulatory and anticancer activities of Capparis moonii fruits extracts

Doshi, Gaurav Mahesh; Pawar, Manjushree kundalik; Chavda, Kajal Haribhai

doi:10.18203/2319-2003.ijbcp20175692

Cited by 3 publications

(7 citation statements)

References 11 publications

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“…Reciprocal of the highest dilution of the test serum agglutination was treated as antibody result. CM fruits extracts at 200 mg/kg showed significant activity and no activity at 100 mg/kg as compared to the standard (Ashwagandha) 9 .…”

Section: Pharmacological Propertiesmentioning

confidence: 81%

“…A graph of percent inhibition v/s concentration was plotted. CM fruits extract showed IC 50 value of MECM (0.338), HMECM (0.905) and AQCM (2.122) as compared to standard (Ashwagandha powder) (0.132) 9 . Another study was done with leaves and stem of Capparis moonii.…”

Section: Pharmacological Propertiesmentioning

confidence: 94%

“…were found to be 0.20, 0.11 and 0.47 mg of gallic acid/g and 78.3, 18.8 and 64.4 mg of rutin/g respectively. Rutin and quercetin were confirmed by HPTLC and HPLC showing well-resolved peaks9 .…”

mentioning

confidence: 85%

“…The cell cultures and media consist of human colon cancer cell line HCT15, human breast cancer cell line MCF7 and standard drug adriamycin (Doxorubicin) CM fruit extracts were found to be unresponsive on selected cell lines at different concentrations studied as compared to standard drug adriamycin 9 .…”

Section: Delayed-type Hypersensitivity (Dth) Responsementioning

confidence: 99%

“…The total ash value, acid insoluble ash, water extractive value, ethanol extractive value, total solid content and loss on drying for CM fruits extracts were found to be 6.4, 0.5, 26.5, 9.4, 26.6 and 15.4% w/v respectively. CM fruits extracts were found to be present positive for flavonoids, steroids, alkaloids, saponins, glycoside, tannins and phenolic compounds, fats and oils9 . Different extracts of stem and leaves of Capparis moonii showed different metabolites in preliminary phytochemical investigations like glycosides were found in chloroform, ethyl acetate, and methanol.…”

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confidence: 98%

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2020

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Capparis moonii wight is a large woody climber or shrub (locally known as Rudanti) having Rasayana (rejuvenating) actions and it is being used in respiratory diseases like cough, bronchial asthma and pulmonary tuberculosis by ayurvedic physicians. It is one of the drugs which have references for its use from centuries but still not much explored in this contemporary era. The review aims to provide a critical and comprehensive evaluation, from the ancient times to our days, of the ethnological, botanical, chemical and pharmacological aspects of Capparis moonii, with a vision for promoting further pharmaceutical research to explore its complete potential as a therapeutic agent. This study was performed by reviewing in extensive details the studies on historical significance and ethnopharmacological applications of Capparis moonii by using classical ayurvedic texts, international scientific databases, books, etc. In addition, the plant taxonomy was validated using certified databases such as Medicinal Plant Names Services (MPNS) and the plant list. A detailed comparative analysis of the available sources for Capparis moonii wight confirmed that fruits of Capparis moonii are absolutely safe with rich source of biologically active components like rutin and quercitin with no toxicity. It has hepatoprotective, insulinomimetic, anti-ulcer, anti-bacterial and antifungal activities. Moreover immunomodulatory and antioxidant properties make it highly beneficial to use this herb in under nutrition and emaciating patients. We believe that this review will help lay the foundation for promoting exhaustive clinical studies to validate its reported activities. INTRODUCTION: Herbal medicines have a strong traditional and conceptual base and the potential to be useful as drugs in terms of safety and efficacy leads to treating different diseases.

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Section: Pharmacological Propertiesmentioning

confidence: 81%

Section: Pharmacological Propertiesmentioning

confidence: 94%

mentioning

confidence: 85%

Section: Delayed-type Hypersensitivity (Dth) Responsementioning

confidence: 99%

mentioning

confidence: 98%

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2020

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Genus Capparis: Chemical, nutritional composition and biological activity

Uysal,

Mohammed,

Sevindik

2024

Studies in Natural Products Chemistry

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Catechin, rutin and quercetin in Quercus mongolica Fisch leaves exert inhibitory effects on multiple cancer cells

Wang

Yue

et al. 2022

Journal of Food Biochemistry

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We aimed to identify anti‐tumor agents in Quercus mongolica Fisch (QMF). Bioactive compounds in QMF leaves, which were extracted using ethanol as a co‐solvent. Five point zero six grams of flavonoids were obtained from 100 g of QMF leaves. Catechin (18.4%), rutin (6.3%), ellagic acid (34.9%), quercetin (5.1%) and kaempferol (20.6%) are the main ingredients of the extracts and were further purified by HPLC. CCK‐8 cell proliferation assay showed that catechin and ellagic acid exerted strong inhibitory effects on the proliferation of all cancer cells with lower IC50 values against MCF‐7 human breast cancer cell lines, SMMC‐7721 human hepatocellular carcinoma cells, HeLa human cervical carcinoma cell lines and SKOV3 human ovarian carcinoma cell lines (p < .05). Catechin, rutin and quercetin induced a higher rate of apoptosis and inhibited all cancer cell proliferation by inducing the G0/G1 phase and G2/M phase arrest (p < .05). However, ellagic acid induced tumor cell death, not through apoptosis and there may be other molecular mechanisms. High levels of catechin and ellagic acid in QMF can be developed as potential drugs to treat different types of cancer cells. Practical applications Quercus species have been widely studied because of their antioxidant, anti‐inflammatory, antimicrobial, and anti‐tumor properties. Bioactive compounds in the leaves of Quercus mongolica Fisch have high levels of catechin and ellagic acid, which exert significant inhibitory properties on the proliferation of various types of cancer cells. Therefore, the bioactive compounds may be potential natural drugs in the prevention of cancer development and progression.

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Quantification of rutin and quercetin by HPTLC/HPLC and in vitro immunomodulatory and anticancer activities of Capparis moonii fruits extracts

Cited by 3 publications

References 11 publications

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Genus Capparis: Chemical, nutritional composition and biological activity

Catechin, rutin and quercetin in Quercus mongolica Fisch leaves exert inhibitory effects on multiple cancer cells

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