Immunomodulation and delivery of macrophages using nano-smooth drug-loaded magnetic microrobots for dual targeting cancer therapy

Song, Xiaoxia; Fu, Wei; Cheang, U Kei

doi:10.1016/j.isci.2022.104507

Cited by 16 publications

(19 citation statements)

References 61 publications

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“…In this regard, Song X et al study introduces drug-loaded magnetic microrobots that can induce macrophages to exhibit the antitumor phenotype, which helps target and suppress cancer cells (Figure 8D). 200 Further, their in vitro experiments showed that these microrobots have good biocompatibility with both normal cells and immune cells. The positively charged doxorubicin (DOX) drug is loaded onto the microrobots' surface and exhibits pH-responsive release behavior using electrostatic interactions.…”

Section: Nanoparticle-based Immunogenic Cellmentioning

confidence: 99%

“…The microrobots are able to target and eliminate cancer cells in a 3D tumor spheroid culture assay due to dual targeting from magnetic guidance and M1 macrophages. 200 Additionally, they demonstrate a strategy to improve microrobots' tumor-targeting and antitumor capabilities by combining magnetic control, macrophages, and pHresponsive drug release.…”

Section: Nanoparticle-based Immunogenic Cellmentioning

confidence: 99%

“…(D) Schematic illustration showing the smooth surfaces of the microrobot trigger M1 polarization of macrophages, which in turn activates their intrinsic targeting and antitumor abilities against cancer cells. Reprinted with permission from ref . Copyright 2022 Elsevier.…”

Section: Extending the Boundaries Of Pancreatic Cancer Therapymentioning

confidence: 99%

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Advancing Cancer Treatment Through Nanotechnology Driven Immunotherapy for Pancreatic Cancer

Kamalasanan,

et al. 2023

ACS Appl. Nano Mater.

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Pancreatic cancer is expected to be the most lethal cancer by 2030; among that, PDAC is the most prominent one, which is immune resistant, posing substantial hurdles to creating effective therapeutics. Despite the advancements in immunotherapy, its application in PDAC is less successful. Uniquely, PDAC tumors are “cold” to immune response mainly due to suppression of spatiotemporal immune signatures from cells and tumor microenvironment. Contrary to other immune-responsive tumors, immunotherapy in combination with chemotherapy in PDAC, is still diffusion-limiting to the drugs and less cytotoxic to cancer cells. Moreover, newer approaches exploring nanotechnology are being tried to make PDAC “hot” and immunogenic in nature and are promising. This review analyses the design strategies of nanosystems for effective spatiotemporal signaling to improve immune response to PDAC tumors. Particularly, that helps to overcome early evasion in phase I, and resistance to the antitumor immune response by modulating cellular and tumor microenvironment (TME) through the latest advancements in nanotechnology, immune mechanisms, and potential delivery routes for PDAC treatment. Ongoing and completed clinical trials of nanotechnology-driven immunotherapies in pancreatic cancer are also highlighted here. Overall, this approach of nanotechnological strategy to enhance immunotherapy in PDAC holds great promise and may contribute to a groundbreaking shift in the therapeutic management of PDAC and reduce the mortality rate of this lethal disease.

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Section: Nanoparticle-based Immunogenic Cellmentioning

confidence: 99%

Section: Nanoparticle-based Immunogenic Cellmentioning

confidence: 99%

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Advancing Cancer Treatment Through Nanotechnology Driven Immunotherapy for Pancreatic Cancer

Kamalasanan,

et al. 2023

ACS Appl. Nano Mater.

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“…Among them, the magnetic target has been demonstrated to be a promising approach for high-efficacy drug delivery due to its fewer side effects, quick response, and low cost [ 25 , 26 ]. The magnetic target methods have been extensively investigated by researchers in vivo and vitro [ 27 , 28 , 29 ]. Additionally, it has been used as a magnetic resonance image (MRI) contrast agent for early diagnosis and real-time monitoring tumor therapy [ 30 , 31 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Multi-Stimuli Responsive Fe3O4 Coated with Diamonds Nanocomposite for Magnetic Assisted Chemo-Photothermal Therapy

Kong

Zhao

et al. 2023

Molecules

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Nanodiamonds with magnetic resonance imaging (MRI) and targeted drug delivery to exert combined effects for biomedical applications have been considered to be an urgent challenge. Herein, a novel bio-nanoarchitectonics(Fe3O4@NDs) with simultaneous imaging and therapeutic capacities was fabricated by covalently conjugating nanodiamonds (NDs) with Fe3O4. Fe3O4@NDs exhibited better biocompatibility and excellent photothermal stability with superb photothermal conversion performance (37.2%). Fe3O4@NDs has high doxorubicin (DOX) loading capacity (193 mg/g) with pH and NIR-responsive release characteristics. Fe3O4@NDs loading DOX showed a combined chemo-photothermal inhibitory effect on the tumor cells. Enhanced T2-weighted MRI contrast toward the tumor, with the assistance of a magnetic field, convinced the Fe3O4@NDs gathered in the tumor more efficiently and could be used for MRI-based cancer diagnosis. Our results revealed an effective strategy to achieve a stimuli-sensitive nanoplatform for multifunctional theranostics by the combined action.

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“…Among the latter, microswimmers are of great interest due to their potential to mask and carry active drugs and direct those towards the specific target site in a complex environment [18,19] . Both chemical and biological microswimmers have been explored for such tasks, with the latter being evolutionarily optimized to survive and perform in complex biological environments [20–51] . Chlamydomonas reinhardtii microalgae are generally recognized as safe (GRAS), biodegradable, and are not considered to trigger the immune response of the human body [52] .…”

Section: Introductionmentioning

confidence: 99%

Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol‐Sensitive Release Platform

Studer

Morina

Shchelik

et al. 2023

Chemistry A European J

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This study reports on the design and engineering of biohybrid microswimmers exploiting a thiol-mediated selfimmolative antibiotic release strategy. The design features a covalent attachment of a vancomycin conjugate via a disulfide-based linker to the surface of the microalgae Chlamydomonas reinhardtii. The antibiotic release from the surface of these biohybrids was triggered by the addition of a thiol-based reducing agent, and, subsequently, the inhibition of bacterial growth was observed for Bacillus subtilis and Staphylococcus aureus. These engineered microbots represent the first example of a microalgae-based drug delivery system with a thiol-mediated, reductive release of an antibiotic drug.

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Immunomodulation and delivery of macrophages using nano-smooth drug-loaded magnetic microrobots for dual targeting cancer therapy

Cited by 16 publications

References 61 publications

Advancing Cancer Treatment Through Nanotechnology Driven Immunotherapy for Pancreatic Cancer

Advancing Cancer Treatment Through Nanotechnology Driven Immunotherapy for Pancreatic Cancer

Synthesis of Multi-Stimuli Responsive Fe3O4 Coated with Diamonds Nanocomposite for Magnetic Assisted Chemo-Photothermal Therapy

Biohybrid Microswimmers for Antibiotic Drug Delivery Based on a Thiol‐Sensitive Release Platform

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