Immunomodulation and antitumor activity of κ-carrageenan oligosaccharides

A review of extractions of seaweed hydrocolloids: Properties and applications

“…One new application of carrageenan in food industry is its use as a protective coating on fresh cut packaged food whereby carrageenan acts as gas barrier, changing the cut surfaces of the fruit and reducing respiration which consequently slows down the discolorations and maintains texture throughout the shelf life [45]. Carrageenan possesses several pharmaceutical properties such as anticoagulant, antithrombotic, antiviral, antitumor, cholesterol lowering effects, immunomodulatory activity and antioxidant activities as depicted in Table 2 [46][47][48][49][50][51]. The application of carrageenan in pharmaceutical field was mostly based on these pharmaceutical aspects.…”

“…[47] Antiviral activity -Kappa carrageenan oligosaccharides (CO-1) derived from carrageenan effectively inhibited influenza A (H1N1) virus [48] Antioxidant activity -Iota-, kappa-, lambda-carrageenan, fucans, fucoidan examined shown potential antioxidant and freeradical scavenging activities [49] Reduced cholesterols and lipids levels -Regular inclusion of carrageenan in daily diet could results in reduction of cholesterol and lipids level in human probably due to its good source of dietary fibers [50] Anticoagulant and antithrombotic activities (blood thinner) -Carrageenan are categorized into different groups, all containing 22-35% of sulphate groups. Lambda-carrageenan shows greater anticoagulant and antithrombotic activities than kappa-carrageenan due to higher content of sulphate groups.…”

PPARγ-dependent anti-tumor and immunomodulatory actions of pioglitazone

“…The discovery and identification of new anti-tumor drugs that can potentiate immune function has become an important goal of research in immunopharmacology and oncotherapy (Yuan et al, 2006). In the current study, treatment of mice with pioglitazone (PIO) resulted in significant reductions in the volume of a tumor (SEC) compared to those levels seen in control mice that received DMSO vehicle instead after injection of EAC cells.…”

Immunomodulatory Effect Of Alginic Acid From Brown Seaweed Sargassum Wightii On Disease Resistance In Penaeus Monodon

“…Fucoidan, a marine sulphated polysaccharide from seaweed appear to inhibit macrophage function in shrimps [23]. Carrageenan, a polysaccharide abundant in certain red seaweeds, induced an increase in macrophage phagocytic activity and in the resistance against bacterial infections after being injected intra-peritoneally in carp (Cyprinus carpio).…”