Immunomodulating Activity of Ginsenoside Rg1 from Panax Ginseng

Kenarova, B; Neychev, H.; Hadjiivanova, Ch.; Petkov, V.

doi:10.1254/jjp.54.447

Cited by 153 publications

(89 citation statements)

References 11 publications

(4 reference statements)

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“…Ginsenosides have been shown to have a wide variety of biological activities including immunomodulatory effects, antioxidant, anti-inflammatory and anti-tumor activity (Kenarova et al, 1990;Attele et al, 1999;Shibata 2001;Park et al, 2003). A series of studies have demonstrated that Ginsenoside Rb1 effectively protects against cerebral, heart and lung ischemia/reperfusion injuries (Zeng et al, 2003;Geng et al, 2005;Li et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Ginsenosides, which are glycosides containing an aglycone (protopanaxadiol or protopanaxatriol) with a dammarane skeleton, are the major effective components of ginseng and have been shown to have a wide variety of biological activities including immunomodulatory effects, antioxidant, anti-inflammatory and anti-tumor activity (Kenarova et al, 1990;Attele et al, 1999;Shibata, 2001;Park et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion-induced liver injury by inhibiting NF-κB activation

Wang

Qiao

et al. 2008

Exp Mol Med

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion-induced liver injury by inhibiting NF-κB activation

Wang

Qiao

et al. 2008

Exp Mol Med

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“…Ginsenoside Rh1 and Rh2 have recently been reported to cause differentiation of F9 teratocarcinoma cells, and it has been suggested that the effects of ginsenosides might have been exerted via binding with a glucocorticoid receptor or its analogous nuclear receptor (60). In nude mice bearing HRA cell tumors, oral administration of Rh2 resulted in a significant retardation of tumor growth, consequently markedly prolonging survival time (58).…”

Section: Identification Of Active Anticarcino-genic Components In Redmentioning

confidence: 99%

Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds

Yun¹,

Lee²,

Lee³

et al. 2001

J Korean Med Sci

206

138

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The failure to improve the five-year survival rate of cancer patients, from one in three in the 1960s to one in two in the 1970s, stimulated awareness of the importance of primary prevention of cancer. Korean investigators carried out extensive long-term anticarcinogenicity experiments with 2000 newborn mice to investigate whether Panax ginseng C.A. Meyer inhibited carcinogenesis induced by several chemical carcinogens in 1978. There was a 22% decrease (p <0.05) in the incidence of urethane induced lung adenoma by the combined use of red ginseng extract. In the group sacrificed at 56 weeks after the treatment with aflatoxin B1, the incidence of hepatoma significantly decreased to 75% by the addition of red ginseng extract (p <0.05). The result showed that natural products can provide hope for human cancer prevention. By the newly established '9 week mediumterm anticarcinogenicity test model of lung tumors in mice' (Yun' s model), we confirmed significant anticarcinogenic effects of powders and extracts of the 6-yr-old dried fresh ginseng, 5-and 6-yr old white ginsengs, and 4-, 5-, and 6-yr old red ginseng. We also demonstrated that the anticarcinogencity of ginseng was more prominent in aged or heat treated extracts of ginseng and red ginseng made by steaming. To investigate the active components for cancer prevention, several fractions of 6-yr old fresh ginseng and red ginseng, four semi-synthetic ginsenoside Rh1, Rh2, Rg3 and Rg5, major saponin components in red ginseng, were prepared. Among the ginsenosides, Rg3 and Rg5 showed statistically significant reduction of lung tumor incidence and Rh2 had a tendency of decreasing the incidence. Ginsenoside Rg3, Rg5 and Rh2 were found to be active anticarcinogenic compounds. Rg3, Rg5 and Rh2 are active components in red ginseng, and they prevent cancer either singularly or synergistically.

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“…Recently, intensive biochemical and molecular studies have shown pharmacological effects of ginseng in the central nervous system and cardiovascular, endocrine, and immune systems as well as in cases of cancer [8][9][10][11][12]. These studies suggest that the preventive effects of ginseng are due to its antiinflammation, anti-oxidation, and cytoprotective activities [13][14].…”

Section: Introductionmentioning

confidence: 99%

Ginseng, the Root of Panax ginseng C.A. Meyer, Protects Ethanol-Induced Gastric Damages in Rat through the Induction of Cytoprotective Heat-Shock Protein 27

et al. 2007

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Ginseng, the root of Panax ginseng C.A. Meyer, has been reported to exert preventive effects on gastropathy via anti-oxidative and anti-inflammatory actions. In this study, we investigated the protective effects of ginseng against ethanol-induced gastric damages in rat. To examine the preventive effect of ginseng, rats received two different ginseng extracts, A and B, 1 h prior to the administration of ethanol. Pretreatment of rats with ginseng extract A and B attenuated the ethanol-induced gastric lesions by 111 AE 48 and 142 AE 47 mm 2 compared to control group (164 AE 54 mm 2 ). Significant induction of cytoprotective heat-shock proteins HSP27 and HSP70 was found in the ginseng-administrated rats, suggesting that the restoration of the proteins might contribute to prevention of ethanol-induced gastric injuries. It is, therefore, suggested that ginseng has a protective effect against ethanol-induced gastric damages by induction of heat-shock proteins 70 and 27.

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Immunomodulating Activity of Ginsenoside Rg1 from Panax Ginseng

Abstract: Abstract-The immunomodulatory activity of ginsenoside Rg1 from Panax ginseng was studied in mice using sheep red cells as the antigen.

Cited by 153 publications

References 11 publications

Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion-induced liver injury by inhibiting NF-κB activation

Ginsenoside Rb1 attenuates intestinal ischemia-reperfusion-induced liver injury by inhibiting NF-κB activation

Anticarcinogenic Effect of Panax ginseng C.A. Meyer and Identification of Active Compounds

Ginseng, the Root of Panax ginseng C.A. Meyer, Protects Ethanol-Induced Gastric Damages in Rat through the Induction of Cytoprotective Heat-Shock Protein 27

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