Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh

Leiro, J.; Castro, Rosario; Arranz, J; Lamas, Jesús

doi:10.1016/j.intimp.2007.02.007

Cited by 279 publications

(157 citation statements)

References 51 publications

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“…This effect was lost after desulfation of the polysaccharides, indicating that the sulfate groups are required for induction of turbot innate immune response by U. rigida polysaccharides (Castro et al 2006). Similarly, Leiro et al (2007) demonstrated that the incubation of RAW macrophages with U. rigida polysaccharides induced an increase in nitrite production, although this effect decreased considerably after desulfation of polysaccharides, suggesting that the sulfate group is important for macrophage activation.…”

Section: Discussionmentioning

confidence: 95%

Characterization of polysaccharides from Hypnea spinella (Gigartinales) and Halopithys incurva (Ceramiales) and their effect on RAW 264.7 macrophage activity

Abdala-Díaz

Chabrillón²,

Cabello‐Pasini³

et al. 2010

J Appl Phycol

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Red algae have been reported to be an important source of polysaccharides with potential immunomodulatory properties. The objective of this study was to characterize the polysaccharides from Halopithys incurva and Hypnea spinella and to evaluate their effect on the synthesis of cytokines by murine cell line RAW 264.7 macrophages. Polysaccharides were obtained by N-cetylpyridinium bromide precipitation and characterized by Fourier transform-infrared spectroscopy. Their effect on the activity of RAW 264.7 macrophages was examined by quantification of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and nitric oxide (NO) production using enzyme-linked immunosorbent assays. The activation of the cytokine IL-6 and NO increased linearly as the concentration of polysaccharides from H. incurva and Hy. spinella increased. In general, the activation of IL-6 and NO was tenfold greater when macrophages were exposed to polysaccharides from H. incurva than when exposed to polysaccharides from Hy. spinella. In contrast, TNF-α concentration did not increase when macrophages were exposed to increasing polysaccharide levels. These results indicate that polysaccharides are strong cytokine IL-6 inducers.

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Section: Discussionmentioning

confidence: 95%

Characterization of polysaccharides from Hypnea spinella (Gigartinales) and Halopithys incurva (Ceramiales) and their effect on RAW 264.7 macrophage activity

Abdala-Díaz

Chabrillón²,

Cabello‐Pasini³

et al. 2010

J Appl Phycol

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“…It was reported that a sulfated heteropolysaccharide from Ulva rigida, which belongs to the same family as Enteromorpha, could markedly activate macrophages (Leiro et al, 2007). It was also found that over sulfated fucoidan inhibited the growth of Lewis lung carcinoma and B16 melanoma in mice, and increasing numbers of sulfate groups in the fucoidan contributes to the effectiveness of its anti-angiogenic and antitumor activities (Koyunagi et al, 2003).…”

Section: Effect Of Ulvta Fasciata Nanoparticles On Urea Uric Acid Cmentioning

confidence: 99%

Potentiality of Silver Nanoparticles Prepared by Ulva fasciata as Anti-nephrotoxicity in Albino-Rats

et al. 2017

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T HE PRESENT study focused on the biosynthesis of silver nanoparticles using the ethanolic extract of the green alga Ulva fasciata (green algae). The synthesized silver nanoparticles were characterized by UV-Vis spectra, TEM (Transmission Electron Microscope) and FT-IR analysis. The absorption spectra of the formed AgNPs was observed at 350 nm, while the FT-IR spectrum revealed a presence of bands at about 2076.96 and 1840.72 cm -1. On the other hand, TEM analysis , exhibited spherical and rod shaped AgNPs with size range of 2 to 200 nm. The chemical constituents, fatty acids, alkaloids, phenolic compounds, terpenoids, aromatic compounds of studied algal extracts were identified by GC-MS. The Gas chromatographymass spectrometry (GC-MS) analysis of the green alga Ulva fasciata ethanolic extract showed a presence of fatty acids, alkaloids, phenolic, terpenoid and aromatic compounds. Potential activity test of the AgNPs formed by Ulva fasciata ethanolic extract against the nephrotoxicity on albino rats revealed good positive results indicated the preventive effects of the disease by using of Ulva fasciata AgNPs.

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“…The carotenoid fucoxanthin has been reported to inhibit NF-jB in HepG2 cells (Liu et al 2013). Sulphated polysaccharides such as fucoidan are known to possess immunomodulating as well as anti-inflammatory effects (Leiro et al 2007). Polyphenols are able to lower NF-jB-inducing kinase (Jaganathan & Mandal 2009), down-regulate hepatic NF-jB, activate PPARc and potentiate the hepatic antioxidant defence system (Mahmoud 2014).…”

Section: Effect Of T Ornata and P Pavonia On Liver Nf-jb And Pparc mentioning

confidence: 99%

Brown seaweeds protect against azoxymethane-induced hepatic repercussions through up-regulation of peroxisome proliferator-activated receptor gamma and attenuation of oxidative stress

Abdella

Mahmoud

El-Derby

2016

Pharmaceutical Biology

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Objective: The current study determines the protective efficacy of the brown seaweeds Turbinaria ornata (Turner) J. Agardh (Sargassaceae) and Padina pavonia (Linnaeus) J.V. Lamouroux (Dictyotaceae) against liver injury induced by azoxymethane (AOM). Materials and methods: Male Swiss mice received 10 mg/kg AOM once a week for two consecutive weeks and then 100 mg/kg daily dose of either T. ornata or P. pavonia ethanolic extract. Thirteen weeks after the first AOM administration and 24 h after the last treatment, overnight fasted mice were sacrificed and samples collected. Results: Compared with the AOM group, both T. ornata and P. pavonia significantly decreased the activity of aminotransferases and the concentration of bilirubin while increased albumin levels in the serum. The antioxidative effect of both extracts was observed from the increased activity of superoxide dismutase and glutathione peroxidase activities in the liver, both of which were decreased by AOM. Moreover, the levels of malondialdehyde and nitric oxide were reduced, and histological findings also confirmed the antihepatotoxic activity. In addition, treatment with T. ornata and P. pavonia significantly increased PPARc and decreased NF-jB expression in the liver of AOM-administered mice. Discussion and conclusion: Our findings indicate that the protective function of T. ornata and P. pavonia on AOM-induced liver injury may be possibly exerted by multiple pathways including abolishment of inflammation and oxidative damage, and activation of PPARc. ARTICLE HISTORY

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Immunomodulating activities of acidic sulphated polysaccharides obtained from the seaweed Ulva rigida C. Agardh

Cited by 279 publications

References 51 publications

Characterization of polysaccharides from Hypnea spinella (Gigartinales) and Halopithys incurva (Ceramiales) and their effect on RAW 264.7 macrophage activity

Characterization of polysaccharides from Hypnea spinella (Gigartinales) and Halopithys incurva (Ceramiales) and their effect on RAW 264.7 macrophage activity

Potentiality of Silver Nanoparticles Prepared by Ulva fasciata as Anti-nephrotoxicity in Albino-Rats

Brown seaweeds protect against azoxymethane-induced hepatic repercussions through up-regulation of peroxisome proliferator-activated receptor gamma and attenuation of oxidative stress

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