Immunology of Recurrent Spontaneous Abortion

Roumandeh, N.; Zare, Ahad; Saremi, A.T.

doi:10.29252/sjrm.2.3.121

Cited by 4 publications

(6 citation statements)

References 18 publications

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Section: Discussionmentioning

confidence: 99%

“…Proposed mechanisms of the therapeutic effect of LIT include production of alloantibodies which act as a protective barrier of embryos against maternal T cell cytotoxicity by masking HLA paternal antigens 30 . Paternal LIT also induces production of anti‐T cell receptor (TCR) idiotypic antibodies directed to autologous TCR, thereby inhibiting maternal immune response against the fetus 30,31 . A significant decrease in peripheral blood Th1 cells, a source of embryotoxic cytokines‐ IFN‐γ and IL‐12, an increase in IL‐4 producing Th2 cells, and a decrease in the TH1/TH2 ratio were observed after immunotherapy 28,32 .…”

Section: Discussionmentioning

confidence: 99%

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Efficacy of lymphocyte immunotherapy in the treatment of recurrent pregnancy loss from alloimmunity: A systematic review and meta‐analysis

Francisco

Tan‐Lim

Jesus

2022

American J Rep Immunol

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Problem The efficacy of lymphocyte immunotherapy (LIT) in the treatment of recurrent pregnancy loss (RPL) from alloimmunity has been debated for years. There is conflicting evidence on the therapeutic role of LIT, since the etiology of most cases of RPL is previously classified as idiopathic. Method of study A systematic search of PubMed and Cochrane databases was done for randomized controlled trials that assessed the efficacy of paternal lymphocyte or third donor LIT among patients with primary or secondary RPL. The primary outcome was live birth rate after LIT. Random‐effect meta‐analysis was conducted using the software RevMan 5.4. Pre‐planned subgroup analyses of source of lymphocytes, timing and frequency of administration, and concentration per immunization dose were conducted. Results Data from eight trials showed a statistically significant benefit of LIT (RR = 1.45, 95% CI 1.05‐2.01). The overall live birth rate is higher in the treatment group (65.6%) compared to placebo or no treatment (45.2%). Subgroup analysis based on source of lymphocytes revealed a trend towards benefit with paternal LIT but with wide confidence interval (RR = 1.34, 95% CI = .84‐2.14). Multiple doses of immunotherapy before pregnancy and low dose (5×106 cells) LIT showed significant benefit. Sensitivity analysis involving studies with a low risk of bias demonstrated significant benefit of increased live birth rate among patients treated with LIT compared to those who received placebo or no treatment (RR = 1.97, 95% CI = 1.53‐2.53). Conclusion LIT demonstrate benefit in improving pregnancy outcome of patients with RPL from alloimmunity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efficacy of lymphocyte immunotherapy in the treatment of recurrent pregnancy loss from alloimmunity: A systematic review and meta‐analysis

Francisco

Tan‐Lim

Jesus

2022

American J Rep Immunol

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“…In the structure of miscarriage, the share of habitual miscarriage is from 5% to 20%. According to the literature, 75-80% of pregnancy losses occur in the first trimester (Garrido-Gimenez C, Alijotas-Reig J., 2015; Roumandeh N. et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…In the structure of the causes of perinatal losses, one of the leading places is occupied by extragenital diseases of women. In 60% of women, extragenital pathology is the cause of obstetric complications (Alijotas- Reig J. et al, 2013;Roumandeh N., 2018;Torchinov A.M. et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Features of Reproductive Function in Women With Miscarriages

Sharhorodska

Melenchuk

2022

SJPU

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The aim of the study was to analyse the reproductive function of women with miscarriages among the population of Lviv region. The data of the results of medical and genetic counseling of 120 women with miscarriages who visited the medical and genetic center and the “Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine” were analyzed. The obtained indicators were compared with similar parameters of the control group: 80 healthy women who asked for family planning consultation. A group of women with miscarriage was formed to study the features of menstrual function, somatic, reproductive and gynecological history in comparison with similar indicators in healthy women. It was found that the majority of women (47 (39.2%) with miscarriages were aged 31–15 years and 74 (61.6%) of women by social status were employees. 52 (48.0%) women of the main group had the onset of menarche significantly later – after 15 years old, in 25 (20.8%) of them the duration of the menstrual cycle was 28–85 days and in 11 (9.1%) – 35–55 days (p < 0.05). Women with miscarriages were significantly more likely to have a complicated somatic history and these are 86 (71.7%), mainly due to pathology of the cardiovascular system – 27 (22.5%), against 43 (53.75%) and 9 (11, 2%) (p <0.05), respectively. All of them 120 (100.0%) had significantly more frequent complications of reproductive and gynecological history due to miscarriages and stillbirths. In the control group this figure was 11 (13.7%) and 19 (23.8%) respectively (p<0.05).

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“…У структурі невиношування вагітності частка звичного викидня складає від 5% до 20%. За даними літератури, 75-80% втрат вагітностей відбуваються у І триместрі [17,18,19].…”

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Miscarriage: A Modern View

Shargorodska

Melenchuk

2022

Act. Probl. of the Modern Med.

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The aim of this study is to analyze the risk factors of miscarriage in modern medical literature. A number of adverse factors and possible risk factors of miscarriage in women of child-bearing age, the latest issues of diagnosis and prevention were scrutinized. In Ukraine, the studies of genetic and demographic processes conducted in recent years have shown that the socially determined demographic crisis observed in the country is significantly deepening due to reproductive losses, which are manifested in an increase in the frequency of lost pregnancies and the birth of inferior offspring in women with diseases of the reproductive system. The frequency of miscarriage ranges from 10% to 30% and does not show a downward trend. In these conditions, the preservation of each pregnancy is important for the demographic development of Ukraine and a factor of national security. The physiological effect of the reproductive function in women occurs due to the harmonious functioning of hormonal, morphological, and immunological mechanisms. The achievements of molecular genetics in recent years have supported the suggestion that miscarriage is not only a polyetiological, but also a multifactorial condition. The recent molecular genetic studies have brought much to deeper understanding of the aetiology and pathogenesis of miscarriage. The study of genetic factors that can underlay the occurrence of miscarriage is a promising direction for the prevention of reproductive losses. The demographic crisis in Ukraine and the unfavourable situation in the field of reproductive health of the population require the development and implementation of complex approaches to the diagnosis and prevention of miscarriage that needs further in-depth investigation of the problem. A significant number of existing methods for predicting and diagnosing miscarriage indicates that there is currently no highly effective and specific method, and the main disadvantages of existing methods for predicting miscarriage, according to the studied literature sources, are low specificity and laboriousness. Among the important tasks, there will be assessment of the population-level data on pregnancy loss and the development of strategies of its prevention.

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Immunology of Recurrent Spontaneous Abortion

Cited by 4 publications

References 18 publications

Efficacy of lymphocyte immunotherapy in the treatment of recurrent pregnancy loss from alloimmunity: A systematic review and meta‐analysis

Efficacy of lymphocyte immunotherapy in the treatment of recurrent pregnancy loss from alloimmunity: A systematic review and meta‐analysis

Features of Reproductive Function in Women With Miscarriages

Miscarriage: A Modern View

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